journal article·2016-03-03Open access

Monitoring Theophylline Concentrations in Saline Using Terahertz ATR Spectroscopy

Kei Takeya, Keita Muto, Yasuhiro Ishihara, Kodo Kawase

Applied Sciences· Volume 6· Issue 3

Abstract

To assess the possibility of terahertz technology for the determination of drug concentration in blood, we endeavored to apply a terahertz (THz) attenuated total reflection (ATR) method to measure the levels of theophylline in saline. A change in reflected THz wave amplitude was observed in a theophylline concentration-dependent manner. This result was obtained with simple measurements of comparisons of the amplitude of the reflected wave, and suggests that it is possible to monitor concentration changes of drugs in liquid material using THz ATR measurements.
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Research context

OpenAlex topics: Terahertz technology and applications · Acoustic Wave Resonator Technologies · Photonic and Optical Devices

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Electrical and Electronic Engineering Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan

Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

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