Optimization of Nonspherical Gold Nanoparticles for Photothermal Therapy
Source abstract
Abstract
Previous investigations devoted to the optimization of nonspherical gold nanoparticles for photothermal therapy (PTT) encountered two issues, namely, the appropriate selection of objective functions and the processing of particle random orientations. In this study, these issues were resolved, and accurate optimization results were obtained for the three typical nonspherical gold nanoparticles (nanospheroid, nanocylinder, and nanorod) by using the T-matrix method. The dependence of the optimization results on the excitation wavelength and the refractive index of tissue was investigated. Regardless of the excitation wavelength and tissue type, gold nanospheroids were found to be the most effective therapeutic agents for PTT. The light absorption ability of optimized nanoparticles could be enhanced by using a laser with a longer wavelength. Finally, the design tolerance for the different sizes of nanoparticles was provided.
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Research context
OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Photoacoustic and Ultrasonic Imaging · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Key Laboratory of Antennas and Microwave Technology, School of Electronic Engineering, Xidian University, Xi’an 710071, China
Laboratory of Novel Light Source and Micro/Nano-Optics, School of Physics and Electronic Engineering, Xinjiang Normal University, Urumqi 830054, China
School of Physics and Optoelectronic Engineering, Xidian University, Xi’an 710071, China
Funding
National Natural Science Foundation of China · University Scientific Research Program of Xinjiang Uygur Autonomous Region · Hundred Young Doctor Introduction Plan of Xinjiang Uygur Autonomous Region · Foundation of Xinjiang Normal University Laboratory of Novel Light Source and Micro/Nano-Optics
References (22)
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