Breast Lesions Screening of Mammographic Images with 2D Spatial and 1D Convolutional Neural Network-Based Classifier

Mammography is a first-line imaging examination that employs low-dose X-rays to rapidly screen breast tumors, cysts, and calcifications. This study proposes a two-dimensional (2D) spatial and one-dimensional (1D) convolutional neural network (CNN) to early detect possible breast lesions (tumors) to reduce patients’ mortality rates and to develop a classifier for use in mammographic images on regions of interest where breast lesions (tumors) may likely occur. The 2D spatial fractional-order convolutional processes are used to strengthen and sharpen the lesions’ features, denoise, and improve the feature extraction processes. Then, an automatic extraction task is performed using a specific bounding box to sequentially pick out feature patterns from each mammographic image. The multi-round 1D kernel convolutional processes can also strengthen and denoise 1D feature signals and assist in the identification of the differentiation levels of normality and abnormality signals. In the classification layer, a gray relational analysis-based classifier is used to screen the possible lesions, including normal (Nor), benign (B), and malignant (M) classes. The classifier development for clinical applications can reduce classifier’s training time, computational complexity level, computational time, and achieve a more accurate rate for meeting clinical/medical purpose. Mammographic images were selected from the mammographic image analysis society image database for experimental tests on breast lesions screening and K-fold cross-validations were performed. The experimental results showed promising performance in quantifying the classifier’s outcome for medical purpose evaluation in terms of recall (%), precision (%), accuracy (%), and F1 score.