Age Estimation from fMRI Data Using Recurrent Neural Network

Finding a biomarker that indicates the subject’s age is one of the most important topics in biology. Several recent studies tried to extract a biomarker from brain imaging data including fMRI data. However, most of them focused on MRI data, which do not provide dynamics and lack attempts to apply recently proposed deep learning models. We propose a deep neural network model that estimates the age of a subject from fMRI images using a recurrent neural network (RNN), more precisely, a gated recurrent unit (GRU). However, applying neural networks is not trivial due to the high dimensional nature of fMRI data. In this work, we propose a novel preprocessing technique using the Automated Anatomical Labeling (AAL) atlas, which significantly reduces the input dimension. The proposed dimension reduction technique allows us to train our model with 640 training and validation samples from different projects under mean squared error (MSE). Finally, we obtain the correlation value of 0.905 between the predicted age and the actual age on 155 test samples. The proposed model estimates the age within the range of ±12 on most of the test samples. Our model is written in Python and is freely available for download.