Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from Portulaca oleracea L.
Source abstract
Abstract
Plant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from Portulaca oleracea L., possess potent antioxidative activities and are expected to exhibit therapeutic potential on the aging process. The current paper describes the concise sequential synthesis of oleracones D–F. Oleracones D and F were efficiently synthesized via selective intramolecular oxa-Michael addition from oleracone E. In addition, we investigated their possible lifespan-extension properties using Caenorhabditis elegans, which is excellently suited as an experimental model to study aging. A significant longevity effect was observed when nematodes were grown with 20 μM of oleracone E.
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Research context
OpenAlex topics: Antioxidants, Aging, Portulaca oleracea · Genetics, Aging, and Longevity in Model Organisms · Hydrogen's biological and therapeutic effects
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Pharmacy, Dankook University, Chenan 31116, Korea
College of Pharmacy, CHA University, Pocheon 11160, Korea
College of Pharmacy, Woosuk University, Jeonbuk 55338, Korea
Funding
National Research Foundation of Korea · Gyeonggi province
References (21)
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