Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives
Source abstract
Abstract
A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2–20 min) and good yields (65%–80%).
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Research context
OpenAlex topics: Synthesis and biological activity · Multicomponent Synthesis of Heterocycles · Synthesis of Organic Compounds
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Research Group of Heterocyclic Compounds, Chemistry Program, Faculty of Basic Sciences, The University of Atlantico, Km 7 Antigua vía Puerto Colombia, Barranquilla-Atlántico, Colombia
Research Group of Heterocyclic Compounds, Department of Chemistry, University of Valle, A. A 25360 Cali, Colombia
Department of Inorganic and Organic Chemistry, University of Jaén, 23071 Jaén, Spain
References (58)
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