Functional Surface Modification of Magnesium Implant by Drug-Loaded Biodegradable Polymer Coating
Source abstract
Abstract
Magnesium has attracted attention as an orthopedic implant material due to its excellent biocompatibility and biodegradability; however, rapid corrosion in physiological environments remains a major limitation. In this study, a polydopamine (PDA) intermediate layer and alginate/chitosan multilayer coating were formed on pure magnesium surfaces, with dexamethasone incorporation to simultaneously improve corrosion resistance and bioactivity. SEM observation revealed that uniform coating layers were formed on alginate/chitosan multilayer coated specimens, and the chemical structure of the coating layers was confirmed through FT-IR and XRD analyses. Electrochemical analysis revealed that the PDA/alginate/chitosan coating group exhibited higher corrosion potential (Ecorr: −0.7514 ± 0.022 V vs. −1.706 ± 0.001 V) and lower corrosion current density (icorr: 2.275 ± 0.15 × 10−7 A/cm2 vs. 1.528 ± 0.47 × 10−4 A/cm2) compared to pure magnesium, with the highest impedance indicating superior corrosion resistance. In tape peel testing, the polydopamine-coated group demonstrated superior adhesion compared to the non-coated group, and sustained release of dexamethasone was confirmed. MC3T3-E1 cell culture results confirmed cell proliferation in all specimens, with the PDA/alginate/chitosan group exhibiting the highest ALP activity compared to other surface-treated groups. Based on these results, the PDA/alginate/chitosan multilayer coating was confirmed to be an effective surface modification method for corrosion control and promotion of osteoblast differentiation on magnesium.
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Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Dental Biomaterials, Institute of Biodegradable Material, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea
Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea
Department of Oral and Maxillofacial Surgery, School of Dentistry, Jeonbuk National University Dental Hospital, Jeonju 54907, Republic of Korea
Research Institute of Clinical Medicine of Jeonbuk National University, Jeonju 54907, Republic of Korea
Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Republic of Korea
Funding
Biomedical Research Institute, Jeonbuk National University Hospital · Ministry of Education
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