History of Urinalysis

Urine is historically the oldest biological material used for diagnostic purposes. Urine testing dates to the ancient Babylonians and Sumerians. Uroscopy consisted of visual and organoleptic assessment (color, clarity, odor, taste testing) of urine. Its principles did not change until the Age of Enlightenment. In the 16th century, when the first microscope was constructed, uroscopy was enriched with the assessment of urine sediment. As chemical methods have developed, tests for various analytes in urine have been introduced into diagnostic methods. The presence of sugar and protein and excretion of urea, creatinine, uric acid and electrolytes, such as sodium, potassium, chlorides, calcium, and magnesium and phosphates, were assessed. Over the years, the set of tests performed on urine has changed, among others, due to the possibility of performing more diagnostically reliable tests in blood. Although currently the most common material for laboratory tests is blood, a general urine test has not lost its importance, and it is a widely performed screening test.