Shortened Acquisition Duration for Brain Tumor 11C-Methionine Positron Emission Tomography on Silicon Photomultiplier Positron Emission Tomography/Computed Tomography

Positron emission tomography/computed tomography (PET/CT) scanners equipped with silicon photomultiplier detectors offer superior sensitivity and count-rate performance. The aim of this study was to evaluate the feasibility and impact of shortening the acquisition duration in brain tumor 11C-methionine PET using a silicon photomultiplier PET/CT system, and to assess how point spread function (PSF) correction influences quantitative values. In the phantom study, a brain tumor phantom was scanned using the Biograph Vision silicon photomultiplier-based PET/CT system. Data were acquired for 10, 5, 3, and 1 min, and the images were reconstructed with and without PSF correction. In the clinical study, 20 patients who underwent 11C-methionine PET were retrospectively analyzed. PET data were acquired over 10 min and subsequently reconstructed for 10, 5, and 3 min. We evaluated quantitative parameters including the maximum standardized uptake value (SUVmax), and their relative errors under shortened acquisition durations were analyzed. In the phantom study, the SUVmax increased with shorter acquisition durations; however, this increase was less pronounced with PSF correction. In the clinical study, relative errors of SUVmax for the 5 and 3 min acquisitions with PSF correction were 2.9 ± 3.8% and 5.2 ± 5.4%, respectively. They were smaller than those without PSF correction (5.5 ± 5.1% and 12.7 ± 8.5%), indicating superior quantitative stability with shortened acquisition duration. The combination of the Biograph Vision system and PSF correction enabled the acquisition of high-quality PET images with shortened scan times.