Correlation Measures in Metagenomic Data: The Blessing of Dimensionality
Source abstract
Abstract
Microbiome analysis has revolutionized our understanding of various biological processes, spanning human health and epidemiology (including antimicrobial resistance and horizontal gene transfer), as well as environmental and agricultural studies. At the heart of microbiome analysis lies the characterization of microbial communities through the quantification of microbial taxa and their dynamics. In the study of bacterial abundances, it is becoming more relevant to consider their relationship, to embed these data in the framework of network theory, allowing characterization of features like node relevance, pathways, and community structure. In this study, we address the primary biases encountered in reconstructing networks through correlation measures, particularly in light of the compositional nature of the data, within-sample diversity, and the presence of a high number of unobserved species. These factors can lead to inaccurate correlation estimates. To tackle these challenges, we employ simulated data to demonstrate how many of these issues can be mitigated by applying typical transformations designed for compositional data. These transformations enable the use of straightforward measures like Pearson’s correlation to correctly identify positive and negative relationships among relative abundances, especially in high-dimensional data, without having any need for further corrections. However, some challenges persist, such as addressing data sparsity, as neglecting this aspect can result in an underestimation of negative correlations.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Metabolomics and Mass Spectrometry Studies · Gut microbiota and health · Bioinformatics and Genomic Networks
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Physics and Astronomy, University of Bologna, 40127 Bologna, Italy
The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA
Department Genetics and Genome Science, University of Connecticut Health Center, Farmington, CT 06032, USA
Funding
EU H2020 “VEO—Versatile Emerging infectious disease Observatory” Project · EU H2020 ERA-HDHL “SYSTEMIC—An integrated approach to the challenge of sustainable food systems”
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