journal article·2025-08-05Open access

Perspectives of Physiotherapists on Immune Functioning in Oncological Rehabilitation in the Netherlands: Insights from a Qualitative Study

Anne M. S. de Hoop, Karin Jäger, Jaap J. Dronkers, Cindy Veenhof, Jelle P. Ruurda, Cyrille A. M. Krul, Raymond H. H. Pieters, Karin Valkenet

Applied Sciences· Volume 15· Issue 15

Abstract

Oncology physiotherapists frequently provide care for patients experiencing severe immunosuppression. Exercise immunology, the science that studies the effects of exercise on the immune system, is a rapidly evolving field with direct relevance to oncology physiotherapists. Understanding oncology physiotherapists’ perspectives on the subject of immune functioning is essential to explore its possible integration into clinical reasoning. This study aimed to assess the perspectives of oncology physiotherapists concerning immune functioning in oncology physiotherapy. For this qualitative research, semi-structured interviews were performed with Dutch oncology physiotherapists. Results were analyzed via inductive thematic analysis, followed by a validation step with participants. Fifteen interviews were performed. Participants’ ages ranged from 30 to 63 years. Emerging themes were (1) the construct ‘immune functioning’ (definition, and associations with this construct in oncology physiotherapy), (2) characteristics related to decreased immune functioning (in oncology physiotherapy), (3) negative and positive influences on immune functioning (in oncology physiotherapy), (4) tailored physiotherapy treatment, (5) treatment outcomes in oncology physiotherapy, (6) the oncology physiotherapist within cancer care, and (7) measurement and interpretation of immune functioning. In conclusion, oncology physiotherapists play an important role in the personalized and comprehensive care of patients with cancer. They are eager to learn more about immune functioning with the goal of better informing patients about the health effects of exercise and to tailor their training better. Future exercise-immunology research should clarify the effects of different exercise modalities on immune functioning, and how physiotherapists could evaluate these effects.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Cancer survivorship and care · Exercise and Physiological Responses · Childhood Cancer Survivors' Quality of Life

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Group Innovation of Human Movement Care, Research Center for Healthy and Sustainable Living, HU University of Applied Sciences Utrecht, 3584 CE Utrecht, The Netherlands

Research Group Innovative Testing in Life Sciences and Chemistry, Research Center for Healthy and Sustainable Living, HU University of Applied Sciences Utrecht, 3584 CE Utrecht, The Netherlands

Department of Rehabilitation, Physiotherapy Science & Sport, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, The Netherlands

Department of Surgery, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands

IRAS-Toxicology, Population Health Sciences, Faculty of Veterinary Sciences, Utrecht University, 3584 CS Utrecht, The Netherlands

References (24)

Show source-provided references
1. Exercise immunology: Future directions10.1016/j.jshs.2019.12.003 ↗
2. The compelling link between physical activity and the body’s defense system10.1016/j.jshs.2018.09.009 ↗
3. Turner, J.E., and Brum, P.C. (2017). Does Regular Exercise Counter T Cell Immunosenescence Reducing the Risk of Developing Cancer and Promoting Successful Treatment of Malignancies?. Oxid Med. Cell Longev., Epub ahead of print.10.1155/2017/4234765 ↗
4. Leisure time physical activity and mortality: A detailed pooled analysis of the dose-response relationship10.1001/jamainternmed.2015.0533 ↗
5. Rehabilitation of Individuals with Cancer10.5535/arm.22036 ↗
6. Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable10.1249/MSS.0000000000002116 ↗
7. Sweegers, M.G., van Doormaal, M.C.M., Conijn, D., and Stuiver, M.M. (2022). KNGF-Richtlijn Oncologie, KNGF/VvOCM.
8. (2024, January 19). Institute for Quality and Efficiency in Health Care. How Does the Immune System Work?, Available online: https://www.ncbi.nlm.nih.gov/books/NBK279364/.
9. Immunological modulation in health and disease10.1038/s41423-023-01066-1 ↗
10. Merriam, S.B. (2002). Basic interpretive qualitative research. Qualitative Research in Practice, Jossey-Bass.
11. Generic Qualitative Approaches: Pitfalls and Benefits of Methodological Mixology10.1177/160940691401300119 ↗
12. Standards for Reporting Qualitative Research10.1097/ACM.0000000000000388 ↗
13. Approaches to reflexivity in qualitative research10.7748/nr2006.04.13.3.7.c5975 ↗
14. Using thematic analysis in psychology10.1191/1478088706qp063oa ↗
15. (2022). ATLAS.ti 22 Windows, ATLAS.
16. Complex Qualitative Data Analysis: Lessons Learned from the Experiences with the Qualitative Analysis Guide of Leuven10.1177/1049732320966981 ↗
17. Saturation in qualitative research: An evolutionary concept analysis10.1016/j.ijnsa.2024.100174 ↗
18. Shao, T., Verma, H.K., Pande, B., Costanzo, V., Ye, W., Cai, Y., and Bhaskar, L.V.K.S. (2021). Physical Activity and Nutritional Influence on Immune Function: An Important Strategy to Improve Immunity and Health Status. Front. Physiol., 12.10.3389/fphys.2021.751374 ↗
19. Aleksandrova, K., Pischon, T., Jenab, M., Bueno-De-Mesquita, H.B., Fedirko, V., Norat, T., Romaguera, D., Knüppel, S., Boutron-Ruault, M.-C., and Dossus, L. (2014). Combined impact of healthy lifestyle factors on colorectal cancer: A large European cohort study. BMC Med., 12.10.1186/s12916-014-0168-4 ↗
20. de Frel, D.L., Atsma, D.E., Pijl, H., Seidell, J.C., Leenen, P.J.M., Dik, W.A., and van Rossum, E.F.C. (2020). The Impact of Obesity and Lifestyle on the Immune System and Susceptibility to Infections Such as COVID-19. Front. Nutr., 7.10.3389/fnut.2020.597600 ↗
21. Toward the development of a comprehensive cancer experience measurement framework
22. An exercise oncology clinical pathway: Screening and referral for personalized interventions10.1002/cncr.32860 ↗
23. O’Brien, K., Ried, K., Binjemain, T., and Sali, A. (2022). Integrative Approaches to the Treatment of Cancer. Cancers, 14.10.3390/cancers14235933 ↗
24. McCormack, B., and McCance, T. (2010). Person-Centred Nursing: Theory and Practice, Wiley.10.1002/9781444390506 ↗