Impact of Nitric Oxide on the Surface Properties of Selected Polymers
Source abstract
Abstract
The change in the surface properties of polymer materials used in an extracorporeal membrane oxygenation (ECMO) device due to nitric oxide (NO) treatment was characterized by zeta-potential and dynamic contact-angle measurements. FTIR-ATR was used to determine the stability of these effects during liquid contact. Polymethyl pentene (PMP), methyl methacrylate acrylonitrile butadiene styrene (MABS), and polyurethane (PU) were investigated. The polymer materials were treated with NO (1000 ppm) for 17 h. The samples for FTIR-ATR measurements were submerged in water or physiological sodium chloride solution for 120 and 240 h after the end of the gas treatment. PMP showed no changes at all. MABS showed decreased contact-angles and increased contact-angle hysteresis. In contrast, PU showed decreased contact-angles and a shift in its zeta-potential curve, indicating a more hydrophilic and acidic surface. The FTIR-ATR measurements showed a slight decrease in the signal intensities after liquid contact. The results indicated an improvement in the liquid contact properties of MABS and the PU due to increased surface hydrophilicity caused mainly by the adsorbed nitric acid (HNO3) molecules formed by the NO treatment. The results presented in this paper point towards a simple and complication-free method of introducing NO into an ECMO circuit.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Tribology and Wear Analysis · Surface Modification and Superhydrophobicity · Silicone and Siloxane Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Physical and Theoretical Chemistry, University of Regensburg, 93040 Regensburg, Germany
Institute of Physical Chemistry and Polymer Physics, Leibniz-Institut für Polymerforschung Dresden e.V., 01069 Dresden, Germany
Funding
ZIM program (Zentrales Innovationsprogramm Mittelstand or Central Innovation Program for small- and medium-sized enterprises (SMEs)) of the Federal Ministry for Economic Affairs and Climate Action
References (55)
Show source-provided references
1. Extra Corporeal Membrane Oxygenation (ECMO) review of a lifesaving technology
2. Veno-venous extracorporeal membrane oxygenation: Cannulation techniques10.21037/jtd.2016.12.88 ↗
3. A Review of the Fundamental Principles and Evidence Base in the Use of Extracorporeal Membrane Oxygenation (ECMO) in Critically Ill Adult Patients10.1177/0885066610384061 ↗
4. Current and future strategies to monitor and manage coagulation in ECMO patients10.1186/s12959-023-00452-z ↗
5. The Hemovent Oxygenator: A New Low-Resistance, High-Performance Oxygenator10.1097/MAT.0000000000001190 ↗
6. Thrombosis and Bleeding in Extracorporeal Membrane Oxygenation (ECMO) Without Anticoagulation: A Systematic Review10.1097/MAT.0000000000001230 ↗
7. ELSO Guidelines for Adult and Pediatric Extracorporeal Membrane Oxygenation Circuits10.1097/MAT.0000000000001630 ↗
8. Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications10.1002/advs.202303259 ↗
9. Vascular Nitric Oxide: Formation and Function
10. Characterization of the interaction of nitric oxide/nitrogen dioxide with the polymer surfaces in ECMO devices10.1007/s10965-024-04109-x ↗
11. Improving Hemocompatibility of Membranes for Extracorporeal Membrane Oxygenators by Grafting Nonthrombogenic Polymer Brushes10.1002/mabi.201700359 ↗
12. The history of extracorporeal oxygenators10.1111/j.1365-2044.2006.04781.x ↗
13. Centrifugal pumps and hemolysis in pediatric extracorporeal membrane oxygenation (ECMO) patients: An analysis of Extracorporeal Life Support Organization (ELSO) registry data10.1016/j.jpedsurg.2017.03.022 ↗
14. Safety and Efficacy of a Novel Pneumatically Driven Extracorporeal Membrane Oxygenation Device10.1016/j.athoracsur.2020.01.039 ↗
15. Membrane oxygenator longevity was higher in argatroban-treated patients undergoing vvECMO10.1111/eci.13963 ↗
16. Nitric Oxide on Extracorporeal Life Support-Circuit Modifications for a Safe Therapy10.1051/ject/202254142 ↗
17. Winnersbach, P., Hosseinnejad, A., Breuer, T., Fechter, T., Jakob, F., Schwaneberg, U., Rossaint, R., Bleilevens, C., and Singh, S. (2022). Endogenous Nitric Oxide-Releasing Microgel Coating Prevents Clot Formation on Oxygenator Fibers Exposed to In Vitro Blood Flow. Membranes, 12.10.3390/membranes12010073 ↗
18. Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion10.1002/jbm.b.30850 ↗
19. The biological role and future therapeutic uses of nitric oxide in extracorporeal membrane oxygenation, a narrative review10.1177/02676591241228169 ↗
20. The effects of nitric oxide on coagulation and inflammation in ex vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass10.1111/aor.14608 ↗
21. Synthesis, Structure, and Properties of Poly(4-Methyl-1 -Pentene)10.1080/15321799208021429 ↗
22. Stamm, M. (2008). Polymer Surfaces and Interfaces: Characterization, Modification and Applications, Springer.10.1007/978-3-540-73865-7 ↗
23. Control of the composition of matrix resin for the design of MABS resin with good transparency and toughness10.1016/j.colsurfa.2022.130608 ↗
24. Impact of prolonged saline solution prime exposure on integrity of extracorporeal membrane oxygenation circuits
25. Larkin, P. (2018). Infrared and Raman Spectroscopy. Principles and Spectral Interpretation, Elsevier. [2nd ed.].10.1016/B978-0-12-804162-8.00002-1 ↗
26. Influence of Surface Roughness on Streaming Potential Method10.1002/ceat.200800180 ↗
27. Electrokinetic properties of natural fibres10.1016/j.colsurfa.2005.06.033 ↗
28. Surface-wetting characterization using contact-angle measurements10.1038/s41596-018-0003-z ↗
29. Hilal, N., Ismail, A.F., Matsuura, T., and Oatley-Radcliffe, D. (2017). Chapter 12-Contact Angle Measurements. Membrane Characterization, Elsevier.
30. Influence of surface roughness on contact angle hysteresis and spreading work10.1007/s00396-020-04680-x ↗
31. Surface modification of poly(vinyl alcohol) fibers to control the fiber-matrix interaction in composites10.1007/s00396-019-04528-z ↗
32. The Wilhelmy method: A critical and practical review10.1680/jsuin.17.00059 ↗
33. Socrates, G. (2010). Infrared and Raman Characteristic Group Frequencies. Tables and Charts, Wiley. [3rd ed.]. repr. as paperback.
34. Gas-Phase Oxidation of Nitric Oxide: Chemical Kinetics and Rate Constant10.1006/niox.1999.0232 ↗
35. Kinetics and Mechanisms of the Gas-Phase Reaction of Water Vapor and Nitrogen Dioxide10.1021/i160052a014 ↗
36. Oxidative Degradation of Polyethylene in Nitrogen Dioxide10.1246/bcsj.36.58 ↗
37. Rates and mechanisms of reactions of nitrogen dioxide with alkenes in solution10.1021/ja00257a025 ↗
38. Reactions of nitrogen oxides with polymers10.1070/RC2000v069n11ABEH000611 ↗
39. Reaction of nitrogen dioxide with linear polyurethane10.1002/pol.1973.170111216 ↗
40. Mechanism of aromatic nitration10.1021/ar50043a003 ↗
41. The thermochemistry and reactivity of alkoxyl radicals10.1021/cr50026a002 ↗
42. The Chemistry of Nitrate Esters10.1021/cr50003a001 ↗
43. New Reactions for the Formation of Organic Nitrate in the Atmosphere10.1021/acsomega.2c03321 ↗
44. Simple model for CO2 absorption in a bubbling water column10.1590/S0104-66322012000100012 ↗
45. Reaction Mechanisms Underlying Unfunctionalized Alkyl Nitrate Hydrolysis in Aqueous Aerosols10.1021/acsearthspacechem.0c00253 ↗
46. Kinetic salt effects in the acid hydrolysis of potassium ethyl malonate in water and in 50% dioxane? Water mixture10.1007/BF00899249 ↗
47. Contact Angle Measurements and Contact Angle Interpretation. 1. Contact Angle Measurements by Axisymmetric Drop Shape Analysis and a Goniometer Sessile Drop Technique10.1021/la9608021 ↗
48. Dynamic Cycling Contact Angle Measurements: Study of Advancing and Receding Contact Angles10.1006/jcis.2001.7840 ↗
49. Solid-Surface Characterization by Wetting10.1146/annurev.matsci.38.060407.132425 ↗
50. Grundke, K., Stamm, M., and Adler, H.-J. (2006). Zeta Potential of Photochemically Modified Polymer Surfaces. Characterization of Polymer Surfaces and Thin Films, Springer. Progress in Colloid and Polymer Science.10.1007/b104970 ↗
51. Wetting kinetics and adhesion strength between polypropylene melt and glass fibre: Influence of chemical reactivity and fibre roughness10.1163/156856102320396148 ↗
52. Electrophilic aromatic nitration: Understanding its mechanism and substituent effects10.1021/jo0609475 ↗
53. Mechanism and regioselectivity of electrophilic aromatic nitration in solution: The validity of the transition state approach10.1007/s00894-017-3561-z ↗
54. Urbański, T. (1983). Chemistry and Technology of Explosives, Pergamon Pr. Repr.
55. Acid-catalyzed carboxylic acid esterification and ester hydrolysis mechanism: Acylium ion as a sharing active intermediate via a spontaneous trimolecular reaction based on density functional theory calculation and supported by electrospray ionization-mass spectrometry10.1039/C5CP02914G ↗