Plasma, Urinary, Erythrocyte, and Platelet Concentrations of Manganese and Molybdenum in Football Players: Differences between Sexes and during the Season
Source abstract
Abstract
Physical activity induces modifications in the concentrations of trace mineral elements. However, studies exploring sex-related differences in manganese (Mn) and molybdenum (Mo) levels among athletes are scarce. Mn and Mo are essentials metals required for a variety of metabolic functions, including those involved in normal human development, the activation of certain metalloenzymes, energy metabolism, and immune system function. They are important cofactors for a variety of enzymes, including those involved in neurotransmitter synthesis and metabolism. The presence of molybdenum (Mo) is essential for several enzymes, including xanthine oxidase (XO), aldehyde oxidase, sulfite oxidase (SO), and the mitochondrial amidoxime reductase component (mARC). This study aimed to: (a) analyse changes in plasma, urine, erythrocyte, and platelet Mn and Mo concentrations throughout a competitive season in men’s and women’s football players, and (b) investigate sex-based discrepancies. A total of 46 football players (22 men: age; 20.62 ± 2.66 years; height; 1.76 ± 0.061 m; weight; 71.50 ± 5.93 kg, and 24 women: age; 23.21 ± 4.11 years; height; 1.65 ± 0.06 m; weight; 59.58 ± 7.17 kg) participated in this study. Three assessments were conducted throughout the competitive season. Data were collected on anthropometry, body composition, nutritional intake, physical fitness, female hormones, haematology, and the determination of Mn and Mo in different biological compartments. Regarding Mn, significant sex differences were observed in plasma, urine, and erythrocyte concentrations (p < 0.05). Moreover, significant variations were observed throughout the season in all analysed biological compartments (p < 0.05). Regarding Mo, significant sex differences were reported in plasma concentrations (p < 0.05). Similarly, there were variations throughout the season in all analysed biological compartments (p < 0.05). Plasma, urine, erythrocyte, and platelet Mn and Mo concentrations could change during a competitive season in football players. On the other hand, sex differences could exist in plasma, urine, and erythrocyte Mn concentrations in football players.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Muscle metabolism and nutrition · Sports injuries and prevention · Sports Performance and Training
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Research Group in Technology Applied to High Performance and Health, Department of Health Sciences, TecnoCampus, Universitat Pompeu Fabra, Mataró, 08302 Barcelona, Spain
Department of Physiology, Sport Science Faculty, University of Extremadura, 10003 Cáceres, Spain
Faculty of Health Sciences, Isabel I University, 09003 Burgos, Spain
Funding
Department of Economy, Science and Digital Agenda of the Regional Government of Extremadura · Regional Government of Extremadura (Department of Employment, Companies and Innovation) · European Union from the European Funds for Regional Development · ‘Pla de recuperació, transformació i resiliència—fnançat per al Unió Europea—Next Generation EU
References (54)
Show source-provided references
1. Heffernan, S.M., Horner, K., De Vito, G., and Conway, G.E. (2019). The role of mineral and trace element supplementation in exercise and athletic performance: A systematic review. Nutrients, 11.10.3390/nu11030696 ↗
2. Micronutrient requirements for athletes10.1016/j.csm.2006.11.009 ↗
3. Minerals, trace elements and related biological variables in athletes and during physical activity10.1016/S0009-8981(01)00598-8 ↗
4. Manganese in health and disease10.1007/978-94-007-7500-8_7 ↗
5. Kabata-Pendias, A., and Mukherjee, A.B. (2007). Trace Elements from Soil to Human, Springer Science & Business Media.10.1007/978-3-540-32714-1 ↗
6. Manganese neurotoxicity and glutamate-GABA interaction10.1016/S0197-0186(03)00037-8 ↗
7. High levels of Mn2+ inhibit secretory pathway Ca2+/Mn2+-ATP ase (SPCA) activity and cause Golgi fragmentation in neurons and glia10.1111/j.1471-4159.2012.07888.x ↗
8. MnSOD antisense treatment and exercise-induced protection against arrhythmias10.1016/j.freeradbiomed.2004.07.025 ↗
9. Abella, A., Clerc, D., Chalas, J., Baret, A., Leluc, R., and Lindenbaum, A. (1987). Concentrations of Superoxide Dismutase (Copper and Manganese), Catalase and Glutathione Peroxidase in Red Cells, Platelets and Plasma in Patients with Rheumatoid Polyarthritis. Annales de Biologie Clinique, Europe PMC.
10. Effects of manganese deficiency on pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity and carbohydrate homeostasis in adult rats10.1007/BF02795535 ↗
11. Jomova, K., Makova, M., Alomar, S.Y., Alwasel, S.H., Nepovimova, E., Kuca, K., Rhodes, C.J., and Valko, M. (2022). Essential metals in health and disease. Chem.-Biol. Interact., 367.10.1016/j.cbi.2022.110173 ↗
12. Oskarsson, A., and Kippler, M. (2023). Molybdenum—A scoping review for Nordic Nutrition Recommendations 2023. Food Nutr. Res., 67.10.29219/fnr.v67.10326 ↗
13. Molybdenum10.1093/advances/nmx001 ↗
14. Serum concentration of cobalt, molybdenum and zinc in aerobic, anaerobic and aerobic-anaerobic sportsmen10.1186/s12970-018-0233-z ↗
15. Molybdenum nutriture in humans10.1177/2156587211406732 ↗
16. Gender differences in the disposition and toxicity of metals10.1016/j.envres.2006.08.003 ↗
17. Chemicals and menopause: Effects on age at menopause and on health status in the postmenopausal period10.1089/jwh.1999.8.227 ↗
18. Influence of a 6-month physical training program on serum and urinary concentrations of trace metals in middle distance elite runners10.1186/s12970-019-0322-7 ↗
19. Effect of an acute exercise until exhaustion on the serum and urinary concentrations of cobalt, copper, and manganese among well-trained athletes10.1007/s12011-018-1500-1 ↗
20. Erythrocyte concentrations of chromium, copper, manganese, molybdenum, selenium and zinc in subjects with different physical training levels10.1186/s12970-020-00367-4 ↗
21. Toro-Román, V., Robles-Gil, M.C., Muñoz, D., Bartolomé, I., Siquier-Coll, J., and Maynar-Mariño, M. (2022). Extracellular and Intracellular Concentrations of Molybdenum and Zinc in Soccer Players: Sex Differences. Biology, 11.10.3390/biology11121710 ↗
22. Influence of an acute exercise until exhaustion on serum and urinary concentrations of molybdenum, selenium, and zinc in athletes10.1007/s12011-018-1327-9 ↗
23. Grijota, F.J., Toro-Román, V., Siquier-Coll, J., Robles-Gil, M.C., Muñoz, D., and Maynar-Mariño, M. (2022). Total Iron Concentrations in Different Biological Matrices—Influence of Physical Training. Nutrients, 14.10.3390/nu14173549 ↗
24. Copper concentration in erythrocytes, platelets, plasma, serum and urine: Influence of physical training10.1186/s12970-021-00426-4 ↗
25. Magnesium and zinc status during the menstrual cycle10.1016/S0002-9378(87)80096-0 ↗
26. Changes in copper and zinc plasma concentrations during the normal menstrual cycle in women10.3109/09513590903247857 ↗
27. Balas, A.R. (2014). Efectos de las Fases del Ciclo Menstrual Sobre la Condición Física, Parámetros Fisiológicos y Psicológicos en Mujeres Jóvenes Moderadamente Entrenadas. Universidad de Extremadura.
28. Moreiras, O., Carbajal, A., Cabrera, L., and Cuadrado, C. (2016). Tablas de Composicion de Alimentos: Guia de Prácticas, Pirámide.
29. Utilization of stored elastic energy in leg extensor muscles by men and women
30. Robles-Gil, M.C., Toro-Román, V., Maynar-Mariño, M., Siquier-Coll, J., Bartolomé, I., and Grijota, F.J. (2023). Aluminum Concentrations in Male and Female Football Players during the Season. Toxics, 11.10.3390/toxics11110920 ↗
31. Toro-Román, V., Muñoz, D., Maynar-Mariño, M., Clemente-Gil, S., and Robles-Gil, M.C. (2023). Sex Differences in Copper Concentrations during a Sports Season in Soccer Players. Nutrients, 15.10.3390/nu15030495 ↗
32. Progressive statistics for studies in sports medicine and exercise science10.1249/MSS.0b013e31818cb278 ↗
33. Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study10.1016/j.envres.2010.03.006 ↗
34. Banci, L. (2013). Metabolism of Molybdenum. Metallomics and the Cell, Springer.10.1007/978-94-007-5561-1 ↗
35. Institute of Medicine (US) Panel on Micronutrients (2001). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, National Academies Press (US).
36. Influence of physical training on erythrocyte concentrations of iron, phosphorus and magnesium10.1186/s12970-020-0339-y ↗
37. Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP–MS10.1016/j.jtemb.2006.08.001 ↗
38. Heitland, P., and Köster, H.D. (2021). Human biomonitoring of 73 elements in blood, serum, erythrocytes and urine. J. Trace Elem. Med. Biol., 64.10.1016/j.jtemb.2020.126706 ↗
39. Seric concentrations of copper, chromium, manganesum, nickel and selenium in aerobic, anaerobic and mixed professional sportsmen10.1186/s12970-018-0212-4 ↗
40. Physical training and copper, iron, and zinc status of swimmers10.1093/ajcn/51.6.1093 ↗
41. Superoxide dismutase in human tissues, cells, and extracellular fluid
42. Sex affects manganese absorption and retention by humans from a diet adequate in manganese10.1093/ajcn/60.6.949 ↗
43. Sex-specific associations of blood and urinary manganese levels with glucose levels, insulin resistance and kidney function in US adults: National health and nutrition examination survey 2011–201610.1016/j.chemosphere.2020.126940 ↗
44. Baj, J., Flieger, W., Barbachowska, A., Kowalska, B., Flieger, M., Forma, A., Teresiński, G., Portincasa, P., Buszewicz, G., and Radzikowska-Büchner, E. (2023). Consequences of Disturbing Manganese Homeostasis. Int. J. Mol. Sci., 24.10.3390/ijms241914959 ↗
45. Sex-and age-differences in blood manganese levels in the US general population: National health and nutrition examination survey 2011–201210.1186/1476-069X-13-87 ↗
46. Bioindicator and exposure data for a population based study of manganese
47. Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 200810.1016/j.neuro.2010.12.006 ↗
48. Driskell, J.A., and Wolinsky, I. (2005). Sports Nutrition: Vitamins and Trace Elements, CRC Press.10.1201/9781420037913 ↗
49. Responses of trace elements to aerobic maximal exercise in elite sportsmen10.5539/gjhs.v6n3p90 ↗
50. Effects of marathon running on the trace minerals chromium, cobalt, nickel, and molybdenum10.1002/jtra.10019 ↗
51. Huang, C.-H., Wang, C.-W., Chen, H.-C., Tu, H.-P., Chen, S.-C., Hung, C.-H., and Kuo, C.-H. (2021). Gender difference in the associations among heavy metals with red blood cell hemogram. Int. J. Environ. Res. Public Health, 19.10.3390/ijerph19010189 ↗
52. Díaz Martínez, A.E., Alcaide Martín, M.J., and González-Gross, M. (2022). Basal values of biochemical and hematological parameters in elite athletes. Int. J. Environ. Res. Public Health, 19.10.3390/ijerph19053059 ↗
53. Pradas, F., García-Giménez, A., Toro-Román, V., Sánchez-Alcaraz, B.J., Ochiana, N., and Castellar, C. (2020). Effect of a padel match on biochemical and haematological parameters in professional players with regard to gender-related differences. Sustainability, 12.10.3390/su12208633 ↗
54. Gender difference in oxidative stress: A new look at the mechanisms for cardiovascular diseases10.1111/jcmm.13038 ↗