Helicobacter pylori—The Bridge between Local and Systemic Inflammation in Children
Source abstract
Abstract
Helicobacter pylori (H. pylori)-associated inflammatory status is no longer a debatable topic in children. The aim of our study was to to compare the inflammatory status in pediatric patients with H. pylori gastritis and non-H. pylori gastritis versus control group. We performed a prospective study on 68 children with dyspeptic symptoms which were divided into 3 groups: 14 children with H. pylori gastritis (group 1), 26 children with non-H. pylori gastritis (group 2) and 28 children with no pathological findings—control group (group 3). Several laboratory parameters, histopathological and immunohistochemistry tests were performed in all children for detecting inflammatory status. We noticed a significant difference in terms of rural area between the three groups (p = 0.0404). Comparing the laboratory parameters between the three groups, we noticed significant differences in terms of serological tests (p = 0094), and NLR (p = 0.0253), the latter being significantly higher in children with H. pylori-induced gastritis as compared to those with non-H. pylori gastritis (0.0107). According to the Dunn’s Multiple Comparison Test, we noticed a significantly elevated neutrophil level in children with H. pylori-induced gastritis when compared to non-H. pylori gastritis group (p = 0.0146), as well as a significantly increased eosinophil count in patients with non-H. pylori gastritis as compared to control group (p = 0.0417). The immunohistochemistry method pointed out no significant variation concerning interleukin (IL 6) between children with gastritis and control group [RR = 1.283, IC (95%): 0.9404–1.751, p = 0.0988]. Additionally, children with gastritis regardless of the etiology have a significant risk of associating increased gastric expression of tumor necrosis factor alpha (TNF α) [RR = 3.967; CI (95%): 1.283–12.263; p = 0.0063]. Moreover, TNF α was significantly associated with presence of H. pylori gastritis (p = 0.0002). The early detection of local inflammation triggered by this infection might preempt gastric carcinogenesis, while identifying H. pylori-induced systemic inflammation lowers the risk of severe extraintestinal manifestations.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Helicobacter pylori-related gastroenterology studies · Eosinophilic Esophagitis · Gastroesophageal reflux and treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Pediatrics I, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Târgu Mureș, Romania
Department of Pathology, “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Târgu Mureș, Romania
Department of Pathology, County Emergency Clinical Hospital of Târgu Mureș, Gheorghe Marinescu Street No. 50, 540139 Târgu Mureș, Romania
Research Center of Oncopathology and Translational Medicine (CCOMT), “George Emil Palade” University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 50, 540139 Târgu Mureș, Romania
Department of Scientific Medical Research Methodology, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology from Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Târgu Mureș, Romania
References (47)
Show source-provided references
1. Life in the Human Stomach: Persistence Strategies of the Bacterial Pathogen Helicobacter Pylori10.1038/nrmicro3016 ↗
2. Mărginean, C.D., Mărginean, C.O., and Meliț, L.E. (2022). Helicobacter Pylori-Related Extraintestinal Manifestations-Myth or Reality. Children, 9.10.3390/children9091352 ↗
3. Pathobiology of Helicobacter Pylori-Induced Gastric Cancer10.1053/j.gastro.2015.09.004 ↗
4. Global Cancer Statistics, 200210.3322/canjclin.55.2.74 ↗
5. Săsăran, M.O., Meliț, L.E., and Dobru, E.D. (2021). MicroRNA Modulation of Host Immune Response and Inflammation Triggered by Helicobacter Pylori. Int. J. Mol. Sci., 22.10.3390/ijms22031406 ↗
6. Association of Severity of Helicobacter Pylori Infection with Peripheral Blood Neutrophil to Lymphocyte Ratio and Mean Platelet Volume10.5005/jp-journals-10018-1204 ↗
7. The Usefulness of Inflammatory Biomarkers in Diagnosing Child and Adolescent’s Gastritis: STROBE Compliant Article10.1097/MD.0000000000016188 ↗
8. Management of Helicobacter Pylori Infection: Guidelines of the Italian Society of Gastroenterology (SIGE) and the Italian Society of Digestive Endoscopy (SIED)10.1016/j.dld.2022.06.019 ↗
9. Cytokine Networks and Their Association with Helicobacter Pylori Infection in Gastric Carcinoma10.1002/jcp.25822 ↗
10. IL-6 and Related Cytokines as the Critical Lynchpins between Inflammation and Cancer10.1016/j.smim.2014.01.001 ↗
11. Acute-Phase Proteins and Other Systemic Responses to Inflammation10.1056/NEJM199902113400607 ↗
12. IL-6 in Diabetes and Cardiovascular Complications10.1111/bph.12713 ↗
13. Dincă, A.L., Meliț, L.E., and Mărginean, C.O. (2022). Old and New Aspects of H. Pylori-Associated Inflammation and Gastric Cancer. Children, 9.10.3390/children9071083 ↗
14. Effectiveness and Tolerance of Anti-Inflammatory Drugs’ Add-on Therapy in Major Mental Disorders: A Systematic Qualitative Review10.1111/acps.12211 ↗
15. Effectiveness of Lycopene on Experimental Testicular Torsion10.1016/j.jpedsurg.2015.11.008 ↗
16. Fecal Helicobacter Pylori GlmM and 16S RRNA Genes Correlate with Serum TNF-α and IL-1β Cytokine Fluctuations10.1556/030.65.2018.030 ↗
17. Pathogenesis of Helicobacter Pylori Infection10.1128/CMR.00054-05 ↗
18. Suganuma, M., Watanabe, T., Sueoka, E., Lim, I.K., and Fujiki, H. (2021). Role of TNF-α-Inducing Protein Secreted by Helicobacter Pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies. Toxins, 13.10.3390/toxins13030181 ↗
19. Association of Neutrophil to Lymphocyte Ratio with Presence and Severity of Gastritis Due to Helicobacter Pylori Infection10.1002/jcla.21669 ↗
20. The Correlation between Tissue Helicobacter Pylori Severity and the Increase in Serum Neutrophil/Lymphocyte Ratio in Patients with Active Chronic Gastritis
21. Association between Admission Neutrophil to Lymphocyte Ratio and Outcomes in Patients with Acute Coronary Syndrome10.1016/j.amjcard.2008.05.006 ↗
22. Elevated Serum Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios Could Be Useful in Lung Cancer Diagnosis10.7314/APJCP.2014.15.6.2651 ↗
23. Preoperative Platelet Lymphocyte Ratio (PLR) is Superior to Neutrophil Lymphocyte Ratio (NLR) as a Predictive Factor in Patients with Esophageal Squamous Cell Carcinoma10.1186/1477-7819-12-58 ↗
24. Ardelean, C.L., Pescariu, S., Lighezan, D.F., Pleava, R., Ursoniu, S., Nadasan, V., and Mihaicuta, S. (2019). Particularities of Older Patients with Obstructive Sleep Apnea and Heart Failure with Mid-Range Ejection Fraction. Medicina, 55.10.3390/medicina55080449 ↗
25. Borka Balas, R., Meliț, L.E., and Mărginean, C.O. (2022). Worldwide Prevalence and Risk Factors of Helicobacter Pylori Infection in Children. Children, 9.10.3390/children9091359 ↗
26. Mehata, S., Parajuli, K.R., Pant, N.D., Rayamajhee, B., Yadav, U.N., Mehta, R.K., Jha, P., Mehta, N., Dhimal, M., and Singh, D.R. (2021). Prevalence and Correlates of Helicobacter Pylori Infection among Under-Five Children, Adolescent and Non-Pregnant Women in Nepal: Further Analysis of Nepal National Micronutrient Status Survey 2016. PLoS Negl. Trop. Dis., 15.10.1371/journal.pntd.0009510 ↗
27. Bordin, D.S., Voynovan, I.N., Andreev, D.N., and Maev, I.V. (2021). Current Helicobacter Pylori Diagnostics. Diagnostics, 11.10.3390/diagnostics11081458 ↗
28. de’Angelis Non-Invasive Tests for the Diagnosis of Helicobacter Pylori: State of the Art
29. Management of Helicobacter Pylori Infection-the Maastricht V/Florence Consensus Report10.1136/gutjnl-2016-312288 ↗
30. Lack of Diagnostic Utility of Specific Immunoglobulin M in Helicobacter Pylori Infection in Children10.1097/MPG.0b013e3181668648 ↗
31. Predictive Value of Elevated Neutrophil-Lymphocyte Ratio on Cardiac Mortality in Patients with Stable Coronary Artery Disease10.1016/j.cca.2008.04.019 ↗
32. A Population-Based Epidemiologic Study of Helicobacter Pylori Infection and Its Association with Systemic Inflammation10.1111/j.1523-5378.2009.00711.x ↗
33. Prevalence of Helicobacter Pylori Infection and Its Link to Coronary Risk Factors in Japanese Patients with Acute Myocardial Infarction10.1253/circj.66.805 ↗
34. Helicobacter Pylori Infection and Coronary Heart Disease in Japanese Patients10.1159/000047337 ↗
35. Increased Risk of Atherosclerosis is Confined to CagA-Positive Helicobacter Pylori Strains: Prospective Results from the Bruneck Study10.1161/01.STR.0000058481.82639.EF ↗
36. CagA Antigen of Helicobacter Pylori and Coronary Instability: Insight from a Clinico-Pathological Study and a Meta-Analysis of 4241 Cases10.1016/j.atherosclerosis.2008.04.051 ↗
37. Infection by Helicobacter Pylori and Acute Myocardial Infarction. Do Cytotoxic Strains Make a Difference?
38. Prospective Study of Potentially Virulent Strains of Helicobacter Pylori and Coronary Heart Disease in Middle-Aged Men10.1161/01.CIR.101.14.1647 ↗
39. Infection with Virulent Strains of Helicobacter Pylori is Not Associated with Ischaemic Heart Disease: Evidence from a Population-Based Case-Control Study of Myocardial Infarction10.1016/S0021-9150(99)00325-1 ↗
40. Significant Association between Serum Interleukin-6 and Helicobacter Pylori Antibody Levels among H. Pylori-Positive Japanese Adults10.1155/2013/142358 ↗
41. C-Reactive Protein in Healthy Subjects: Associations with Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating from Adipose Tissue?10.1161/01.ATV.19.4.972 ↗
42. Association of Respiratory Syncytial Virus Bronchiolitis with the Interleukin 8 Gene Region in UK Families10.1136/thorax.55.12.1023 ↗
43. Polymorphisms of the IL-6, IL-8 and IL-10 Genes and the Risk of Gastric Pathology in Patients Infected with Helicobacter Pylori10.1016/j.jmii.2015.03.002 ↗
44. Serum Levels of Tumor Necrosis Factor-Alpha, Interleukin-6 and Interleukin-8 Are Not Increased in Dyspeptic Patients with Helicobacter Pylori-Associated Gastritis10.1080/09629350410001664789 ↗
45. High Helicobacter Pylori Bacterial Load and Low Cytokine Expression Levels Are Associated with Nodular Gastropathy10.1007/s10620-019-05769-2 ↗
46. Helicobacter Pylori and T Helper Cells: Mechanisms of Immune Escape and Tolerance10.1155/2015/981328 ↗
47. Association of TNF-α but Not IL-1β Levels with the Presence of Helicobacter Pylori Infection Increased the Risk of Peptic Ulcer Development10.1016/j.cyto.2018.01.003 ↗