Plebeian Sage (Salvia plebeia R. Br) Extract Ameliorates Inflammation and Cartilage Degradation in Surgically Induced Osteoarthritis Rats
Source abstract
Abstract
Osteoarthritis (OA), the most prevalent articular disease with the clinical syndrome of joint pain accompanied by varying degrees of functional limitation, reduces the quality of elderly life. In this study, the effects of Plebeian sage extract (PS) on anti-inflammatory and anti-articular cartilage degradation activities were evaluated in rats with surgically induced OA. PS supplement for 12 weeks significantly decreased Mankin scores, including inflammatory cell numbers, and improved surface cartilage damage and mean femur and tibia articular cartilage (AC) thicknesses in OA rats. PS diminished IL-1β, IL-6, TNF-α, MMP-2, MMP-3, and MMP-9, as well as lipocalin-2 levels in serum or cartilage, which were increased due to OA. The results suggested that PS decreased joint inflammation and loss of articular cartilage by suppressing provocative responses and synovial tissue decimation in the OA model. Thus, PS may be used as a novel potential therapeutic regime for OA in the elderly.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Inflammatory mediators and NSAID effects · Pharmacological Effects of Medicinal Plants
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Jeonbuk, Korea
College of Korean Medicine, Daegu Haany University, Daegu 38610, Kyungbuk, Korea
Nutracore Co., Ltd., Yeongtong, Suwon 16229, Gyeonggi, Korea
Department of Functional Foods and Biotechnology, Jeonju University, Jeonju 55069, Jeonbuk, Korea
Funding
Rural Development Administration
References (49)
Show source-provided references
1. Evaluation of the structure-modifying effects of diacerhein in hip osteoarthritis10.1002/1529-0131(200111)44:11<2539::AID-ART434>3.0.CO;2-T ↗
2. Glucosamine sulfate use and delay of progression of knee osteoarthritis10.1001/archinte.162.18.2113 ↗
3. Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes10.1254/jjp.85.101 ↗
4. Osteoarthritis10.1002/jcp.21258 ↗
5. Subchondral bone microenvironment in osteoarthritis and pain10.1038/s41413-021-00147-z ↗
6. Microenvironment in subchondral bone: Predominant regulator for the treatment of osteoarthritis10.1136/annrheumdis-2020-218089 ↗
7. Choi, B.R., Kang, S.J., Kim, J.L., Lee, Y.J., and Ku, S.K. (2020). Anti-osteoarthritic effects of a mixture of dried pomegranate concentrate powder, eucommiae cortex, and achyranthis radix 5:4:1 (g/g) in a surgically induced osteoarthritic rabbit model. Nutrients, 12.10.3390/nu12030852 ↗
8. Inomata, K., Tsuji, K., Onuma, H., Hoshino, T., Udo, M., Akiyama, M., Nakagawa, Y., Katagiri, H., Miyatake, K., and Sekiya, I. (2019). Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint. BMC Musculoskelet. Disord., 20.10.1186/s12891-018-2391-1 ↗
9. Inflammation in osteoarthritis10.1097/BOR.0b013e328349c2b1 ↗
10. The NF-κB signalling pathway in osteoarthritis10.1016/j.biocel.2013.08.018 ↗
11. Expanding the adipokine network in cartilage: Identification and regulation of novel factors in human and murine chondrocytes10.1136/ard.2010.132399 ↗
12. Lipocalin 2: A new mechanoresponding gene regulating bone homeostasis10.1002/jbmr.2341 ↗
13. Circulating lipocalin 2 levels predict fracture-related hospitalizations in elderly women: A prospective cohort study10.1002/jbmr.2546 ↗
14. Neutrophil gelatinase-associated lipocalin is expressed in osteoarthritis and forms a complex with matrix metalloproteinase 910.1002/art.22879 ↗
15. Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis10.1186/ar2587 ↗
16. Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice10.1016/j.joca.2016.07.009 ↗
17. Effect of Angelica sinensis polysaccharides on osteoarthritis in vivo and in vitro: A possible mechanism to promote proteoglycans synthesis10.1155/2013/794761 ↗
18. Nutrition, osteoarthritis and cartilage metabolism10.1007/s40520-019-01191-w ↗
19. Inappropriate claims from non-equivalent medications in osteoarthritis: A position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)10.1007/s40520-017-0861-1 ↗
20. Commentary on recent therapeutic guidelines for osteoarthritis10.1016/j.semarthrit.2014.12.003 ↗
21. Current nutraceuticals in the management of osteoarthritis: A review10.1177/1759720X11436238 ↗
22. Osteoarthritis and its management-Epidemiology, nutritional aspects and environmental factors10.1016/j.autrev.2018.06.002 ↗
23. Recently highlighted nutraceuticals for preventive management of osteoarthritis10.5312/wjo.v9.i11.255 ↗
24. Alterations of amino acid metabolism in osteoarthritis: Its implications for nutrition and health10.1007/s00726-015-2168-x ↗
25. Chen, Y.P., and Chu, Y.L. (2020). Tsuang, Y.H.; Wu, Y.; Kuo, C.Y.; Kuo, Y.J. Anti-inflammatory effects of adenine enhance osteogenesis in the osteoblast-like MG-63 cells. Life, 10.10.3390/life10070116 ↗
26. Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-kappaB activation, and induces human osteoblastic and chondrocytic differentiation10.1016/j.cbi.2009.12.003 ↗
27. Mattiuzzo, E., Faggian, A., Venerando, R., Benetti, A., Belluzzi, E., Abatangelo, G., Ruggieri, P., and Brun, P. (2021). In vitro effects of low doses of β-Caryophyllene, ascorbic acid and d-Glucosamine on human chondrocyte viability and inflammation. Pharmaceuticals, 14.10.3390/ph14030286 ↗
28. Effects of Dipsacus asperoides extract on monosodium iodoacetate-induced osteoarthritis in rats based on gene expression profiling
29. Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract10.1080/13880209.2018.1557700 ↗
30. Anti-oxidative and anti-allergic effects of Salvia plebeia R. ethanol extracts
31. Antioxidative activity and nitrite scavenging ability of methanol extract from Salvia plebeia R. Br
32. Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model10.1186/s40659-016-0102-7 ↗
33. Salvia plebeian extract inhibits the inflammatory response in human rheumatoid synovial fibroblasts and a murine model of arthritis10.1016/j.phymed.2015.01.007 ↗
34. Antioxidant activity of compounds isolated from Salvia plebeian10.1016/S0308-8146(00)00191-6 ↗
35. Phenolic profiling and quantitative determination of common sage (Salvia plebeia R. Br.) by UPLC-DAD-QTOF/MS10.1007/s00217-018-3076-6 ↗
36. Homoplantaginin inhibits palmitic acid-induced endothelial cells inflammation by suppressing TLR4 and NLRP3 inflammasome10.1097/FJC.0000000000000318 ↗
37. Protective effects of calcium gluconate on osteoarthritis induced by anterior cruciate ligament transection and partial medial meniscectomy in Sprague-Dawley rats10.1186/1749-799X-9-14 ↗
38. Efficacy test of Polycan, a beta-glucan originated from Aureobasidium pullulans SM-2001, on anterior cruciate ligament transection and partial medial meniscectomy-induced-osteoarthritis rats10.4014/jmb.1110.10078 ↗
39. Effects of HPL-04 on degenerative osteoarthritis10.3746/jkfn.2014.43.1.030 ↗
40. Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia10.1016/j.joca.2006.05.001 ↗
41. Effect of Boswellia serrata extracts on degenerative osteoarthritis in vitro and in vivo models10.3746/jkfn.2014.43.5.631 ↗
42. Matrix metalloproteinases10.1074/jbc.274.31.21491 ↗
43. Pathogenesis of joint damage in rheumatoid arthritis
44. Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis10.1136/ard.2009.122002 ↗
45. Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: Involvement of matrix metalloproteinase 310.1002/art.22337 ↗
46. What’s new in our understanding of the role of adipokines in rheumatic diseases?10.1038/nrrheum.2011.107 ↗
47. Proteomic characterization of mouse cartilage degradation in vitro10.1002/art.23789 ↗
48. Inducible nitric oxide synthase and inflammatory diseases10.1007/BF03401781 ↗
49. Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish10.1016/j.cbi.2016.01.020 ↗