journal article·2024-04-29Open access

Analysis of Operated Ankle Fractures in Elderly Patients: Are They All Osteoporotic?

Giuseppe Rinonapoli, Marco Donantoni, Paolo Ceccarini, Auro Caraffa

Applied Sciences· Volume 14· Issue 9

Abstract

Background: Osteoporosis represents a global problem, which involves high risks of disability and death due to the consequences of fragility fractures. The aim of our study is to verify what type of relationship there is between ankle fractures and osteoporosis. Specifically, we aim to understand how the clinical and anamnestic characteristics of patients, along with the radiographic features of these fractures, may contribute to considering them as osteoporotic fractures. Methods: The study group includes 51 consecutive patients aged 60 years or older operated for ankle fracture from May to October 2022. The fractures were divided into uni-, bi-, or trimalleolar based on the plain X-rays. All patients underwent femoral and vertebral bone mineralometry by DXA associated with the FRAX questionnaire. Results: Ankle fractures in the elderly were associated with reduced BMD (76.5% of the total patients examined, 83.8% considering only women) and low-energy traumas (82%). Furthermore, these fractures present features of increased complexity as bone mass decreases. Conclusions: Ankle fractures in the elderly exhibit characteristics that suggest a relationship with bone fragility. For these reasons, it might be advisable to initiate a comprehensive fracture risk assessment in elderly patients who experience an ankle fracture. These fractures should not be underrated, and antiresorptive therapy must always be taken into consideration when selecting patients at risk.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Bone health and osteoporosis research · Bone fractures and treatments · Pelvic and Acetabular Injuries

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Orthopedic and Traumatology Unit, University of Perugia, “Santa Maria della Misericordia” Hospital, P.le G. Menghini 3, 06156 Perugia, Italy

Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy

References (58)

Show source-provided references
1. Consensus development conference: Diagnosis, prophylaxis, and treatment of osteoporosis10.1016/0002-9343(93)90218-E ↗
2. Is ankle fracture related to low bone mineral density and subsequent fracture? A systematic review10.1016/j.afos.2020.08.003 ↗
3. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women10.1001/jama.2009.50 ↗
4. Rinonapoli, G., Ruggiero, C., Meccariello, L., Bisaccia, M., Ceccarini, P., and Caraffa, A. (2021). Osteoporosis in men: A review of an underestimated bone condition. Int. J. Mol. Sci., 22.10.3390/ijms22042105 ↗
5. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report10.1007/BF01622200 ↗
6. Tarantino, U., Iolascon, G., Cianferotti, L., Masi, L., Marcucci, G., Giusti, F., Marini, F., Parri, S., Feola, M., and Rao, C. (2017). Clinical Guidelines for the Prevention and Treatment of Osteoporosis: Summary Statements and Recommendations from the Italian Society for Orthopaedics and Traumatology, Springer International Publishing.10.1007/s10195-017-0474-7 ↗
7. Classification of osteoporosis based on bone mineral densities10.1359/jbmr.2001.16.5.901 ↗
8. The management of osteoporosis after fragility fracture: The orthopaedic perspective10.2106/JBJS.RVW.16.00098 ↗
9. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women10.1007/s00198-007-0343-y ↗
10. Interpretation and use of FRAX in clinical practice10.1007/s00198-011-1713-z ↗
11. Rinonapoli, G., Pace, V., Ruggiero, C., Ceccarini, P., Bisaccia, M., Meccariello, L., and Caraffa, A. (2021). Obesity and Bone: A Complex Relationship. Int. J. Mol. Sci., 22.10.3390/ijms222413662 ↗
12. The obesity paradox and osteoporosis10.1007/s40519-018-0505-2 ↗
13. Incidence of vertebral fracture in europe: Results from the european prospective osteoporosis study (EPOS)10.1359/jbmr.2002.17.4.716 ↗
14. Hip fractures in the elderly: A world-wide projection10.1007/BF01623184 ↗
15. Prevalence of vertebral fractures in women and men in the population-based Tromsø study
16. The Epidemiology of Osteoporosis
17. Foot and ankle fractures in elderly white women. Incidence and risk factors10.2106/00004623-200305000-00008 ↗
18. A Comparison of Ankle Fractures Relative to Other Fragility Fractures: A Review and Analysis of the American Orthopaedic Association’s Own the Bone Database10.1177/10711007231178536 ↗
19. Fracture prevention service to bridge the osteoporosis care gap
20. Increasing number and incidence of low-trauma ankle fractures in elderly people: Finnish statistics during 1970-2000 and projections for the future10.1016/S8756-3282(02)00832-3 ↗
21. Epidemiology of osteoporotic ankle fractures in elderly persons in Finland10.7326/0003-4819-125-12-199612150-00007 ↗
22. Osteoporosis seminar 201910.1016/S0140-6736(18)32112-3 ↗
23. UK Clinical Guideline for the Prevention and Treatment of Osteoporosis10.1007/s11657-022-01061-5 ↗
24. The effectiveness of mobilization with movement on pain, balance and function following acute and sub acute inversion ankle sprain—A randomized, placebo controlled trial10.1016/j.ptsp.2020.12.016 ↗
25. Ankle fractures in the elderly: Risks and management challenges
26. Ankle fractures in the elderly: What you get depends on where you live and who you see10.1097/01.bot.0000177105.53708.a9 ↗
27. Ankle fractures in the elderly: Initial and long-term outcomes10.3113/FAI.2008.1184 ↗
28. Are low-energy open ankle fractures in the elderly the new geriatric hip fracture?10.1053/j.jfas.2014.10.015 ↗
29. Evaluation of one-year mortality after geriatric ankle fractures in patients admitted to nursing homes10.1016/j.injury.2015.05.020 ↗
30. Morbidity and mortality associated with geriatric ankle fractures10.2106/JBJS.O.00095 ↗
31. Lifestyle and other factors predict ankle fractures in perimenopausal women: A population-based prospective cohort study10.1016/S8756-3282(01)00649-4 ↗
32. Prior ankle fractures in postmenopausal women are associated with low areal bone mineral density and bone microstructure alterations10.1007/s00198-015-3119-9 ↗
33. Fractures and low axial bone density in perimenopausal women10.1016/0895-4356(94)00220-K ↗
34. Abnormal microarchitecture and stiffness in postmenopausal women with ankle fractures10.1210/jc.2011-0309 ↗
35. Is osteoporosis a risk factor for ankle fracture?: Comparison of bone mineral density between ankle fracture and control groups10.1016/j.afos.2017.11.005 ↗
36. (2024, March 29). AIFA. Nota 79, Available online: https://www.aifa.gov.it/documents/20142/1728074/nota-79.pdf.
37. Bergh, C., Wennergren, D., Möller, M., and Brisby, H. (2020). Fracture incidence in adults in relation to age and gender: A study of 27,169 fractures in the Swedish Fracture Register in a well-defined catchment area. PLoS ONE, 15.10.1371/journal.pone.0244291 ↗
38. The interdisciplinary fracture liaison service improves health-related outcomes and survival of older adults after hip fracture surgical repair10.1007/s11657-022-01171-0 ↗
39. Fracture history in osteoporosis: Risk factors and its effect on quality of life10.5152/balkanmedj.2014.13265 ↗
40. Declining incidence of fall-induced ankle fractures in elderly adults: Finnish statistics between 1970 and 201410.1007/s00402-016-2524-7 ↗
41. Ankle fractures have features of an osteoporotic fracture10.1007/s00198-013-2394-6 ↗
42. Which fractures are associated with low appendicular bone mass in elderly women? The Study of Osteoporotic Fractures Research Group10.7326/0003-4819-115-11-837 ↗
43. The ankle fracture as an index of future fracture risk. A 25–40 year follow-up of 1063 cases10.3109/17453679308993674 ↗
44. Clinical and demographic factors associated with fractures among older Americans10.1007/s00198-010-1300-8 ↗
45. A Comprehensive Review on Postmenopausal Osteoporosis in Women
46. Alta prevalencia de deficiencia de vitamina D en mujeres posmenopáusicas de una consulta reumatológica en Madrid. Evaluación de dos pautas de prescripción de vitamina D10.1016/S0025-7753(00)71283-8 ↗
47. Do bisphosphonates reduce the risk of osteoporotic fractures? An evaluation of the evidence to date
48. Ankle fractures of the geriatric patient: A narrative review10.1530/EOR-22-0082 ↗
49. Osteoporotic ankle fractures10.1016/j.ocl.2013.01.010 ↗
50. Bone density correlates with clinical outcomes after ankle fracture fixation10.1007/s00402-018-3017-7 ↗
51. The management of ankle fractures in the elderly10.1016/j.injury.2007.08.005 ↗
52. Management of Osteoporotic and Neuropathic Ankle Fractures in the Elderly10.1007/s13670-017-0196-y ↗
53. A United Kingdom perspective on the relationship between body mass index (BMI) and bone health: A cross sectional analysis of data from the Nottingham Fracture Liaison Service10.1016/j.bone.2013.11.024 ↗
54. Obesity is not protective against fracture in postmenopausal women: GLOW10.1016/j.amjmed.2011.06.013 ↗
55. The association between fracture and obesity is site-dependent: A population-based study in postmenopausal women10.1002/jbmr.1466 ↗
56. Association between ankle fractures and obesity10.1053/j.jfas.2012.05.016 ↗
57. The Effects of Age, Adiposity, and Physical Activity on the Risk of Seven Site-Specific Fractures in Postmenopausal Women10.1002/jbmr.2826 ↗
58. Cardoso, D.V., Paccaud, J., Dubois-Ferrière, V., Barea, C., Hannouche, D., Veljkovic, A., and Lübbeke, A. (2022). The effect of BMI on long-term outcomes after operatively treated ankle fractures: A study with up to 16 years of follow-up. BMC Musculoskelet. Disord., 23.10.1186/s12891-022-05247-3 ↗