Optimization of the Antifungal Property in a Composite of Polyurethane and Silver Nanoparticles against the Trichophyton rubrum Fungus
Source abstract
Abstract
This research aims to analyze and optimize the antifungal property of a composite material made of polyurethane (PUR) and silver nanoparticles (AgNPs) against the fungus Trichophyton rubrum to find the optimal parameters that allow the highest inhibition of the fungal growth to be used in healthcare aimed at the population vulnerable to fungal infections, such as people suffering from diabetes mellitus, thus creating an opportunity for the generation of antifungal products for healthcare applications. This study analyzes the effect of three variables on the antifungal properties of the composite material: nanoparticle size, concentration, and the application of an ultrasonic treatment as a method to aid the dispersion of the AgNPs into PUR matrix. The proposed methodology includes tests in accordance with a standar to evaluate the growth inhibition of the fungi on a culture medium. A categorical logistic regression model was adjusted from 23 factorial design with five replicates, which was optimized by the use of multi-objective genetic algorithms. The experimental factors showed a significant effect on the growth inhibition of the fungus, and the optimal levels were determined.
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Research context
OpenAlex topics: Medical and Biological Ozone Research · Nanoparticles: synthesis and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Industrial Engineering División, Tecnológico Nacional de México/ITS de Purísima del Rincón, Blvd. Del Valle 2301, Guardarrayas, Purísima del Rincón 36413, Mexico
Industrial Processes and Energy Division, Centro de Innovación Aplicada en Tecnologías Competitivas, Omega 201 Col. Industrial Delta, León 37545, Mexico
Engineering Area, Universidad Iberoamericana León, Blvd. Jorge Vértiz Campero 1640 Col. Cañada de Alfaro, León 37238, Mexico
Engineeering and Materials Chemistry Division, Centro de Investigación en Materiales Avanzados, Av. Miguel de Cervantes 120, Complejo Industrial Chihuahua, Chihuahua 31136, Mexico
Funding
PRODEP · Idea Guanajuato in Convocatoria Mentefactura Tecnológica Submodalidad Ciencia Productiva
References (44)
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