DataVXApplied SciencesPaper
journal article·2021-02-24Open access

Non-Thermal Intervention of Lung Tumor by Core-Shell Magnetic Nanoparticles in a Magnetic Field

Naming Zhang, Ziang Wang, Shuya Ning, Shuhong Wang, Song Wang, Hao Qiu

Applied Sciences· Volume 11· Issue 5
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Source abstract

Abstract

K-Ras mutations result in normal cells dividing uncontrollably and becoming cancerous. The prognosis is currently poor for patients due to the lack of drugs that can effectively target these mutations. In this study, magnetic nanoparticles (MNPs) were prepared, characterized, and cooperated with a magnetic field to intervene in the growth of lung tumor cells. The rise in temperature of a stimulation coil was studied by numerical calculation. The non-thermal effects of MNPs under a magnetic force were analyzed. The cell experiments showed that the growth of A549 tumor cells slowed down. The result of a wound-healing assay also indicated that the migration of tumor cells was suppressed. Compared with magnetic stimulation without MNPs, MNPs enhanced the inhibitory effects of a magnetic field. This study suggests a new way to treat K-Ras driven lung tumors using non-thermal effects of MNPs without the side effects caused by thermal effects.
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Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Electrohydrodynamics and Fluid Dynamics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi’an Jiaotong University, Xi’an 710049, China

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21225, USA

School of Electronic Information and Artificial Intelligence, Shaanxi University of Science and Technology, Xi’an, 710021, China

College of Water Resources and Architectural Engineering, Northwest A&F University, Xianyang 712100, China

Funding

National Natural Science Foundation of China · China Postdoctoral Science Foundation · Natural Science Basic Research Program of Shaanxi Province · Fundamental Research Funds for the Central Universities · Scientific Research Funds for New Teacher of Xi’an Jiaotong University · The Young Talent Fund of University Association for Science and Technology in Shaanxi · The Scientific Research Program of Shaanxi Provincial Education Department

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