Oxidative Thermolysis of Sulfobutyl-Ether-Beta-Cyclodextrin Sodium Salt: A Kinetic Study
Source abstract
Abstract
Sulfobutyl-ether-beta-cyclodextrin sodium salt (SBECD) is a modified cyclodextrin widely used in the pharmaceutical industry to enhance the solubility and stability of poorly water-soluble drugs. As a derivative of beta-cyclodextrin, it is produced by introducing sulfobutyl ether groups into the beta-cyclodextrin molecule, which significantly increases its water solubility and decreases its toxicity compared to unmodified cyclodextrins. This study investigates the spectral and PXR diffraction characterization of SBECD, its thermal stability profile, and decomposition mechanism using isoconversional methods. Since the simple ASTM E698 method does not provide realistic data, the Flynn–Wall–Ozawa, Friedman, and NPK methods were employed, leading to the kinetic triplet that characterizes the oxidative thermolysis of this compound.
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Research context
OpenAlex topics: Thermal and Kinetic Analysis · Crystallization and Solubility Studies · Chemical Thermodynamics and Molecular Structure
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Pharmacy I, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300011 Timișoara, Romania
Advanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babes University of Medicine and Pharmacy, 300041 Timișoara, Romania
Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University of Timișoara, 300223 Timișoara, Romania
Research Centre for Thermal Analysis in Environmental Problems, West University of Timișoara, 300115 Timișoara, Romania
Department of Medicine XIV, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, 300011 Timișoara, Romania
Funding
Victor Babes University of Medicine and Pharmacy Timișoara
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