journal article·2024-05-10Open access

Unavoidability and Functionality of Nervous System and Behavioral Randomness

Carlos M. Gómez, Elena I. Rodríguez-Martínez, María A. Altahona-Medina

Applied Sciences· Volume 14· Issue 10

Abstract

The basic functioning of the central nervous system is based on the opening and closing of ionic channels in the membranes of neurons. The behavior of ionic channels is considered to be a random process with an exponential probability distribution function. The central limit theorem implies that the mean of the sum of random variables generates a distribution in which the new variable tends to be normally distributed. The theorem implicitly implies that randomness can be embedded in a certain probability distribution but does not disappear. The present report will explore the possible implications for the functioning of nervous system and behavior of the constituent neural randomness. The possible functionality of “noise” to increase the exploratory space of nervous and behavioral systems will be considered.
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Research context

OpenAlex topics: Neural dynamics and brain function · Gene Regulatory Network Analysis · stochastic dynamics and bifurcation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Experimental Psychology, University of Seville, 41018 Seville, Spain

Funding

Spanish Agencia Estatal de Investigación (AEI) · Consejería de Innovación, Ciencia y Empresa of the Junta de Andalucía

References (45)

Show source-provided references
1. Hille, B. (2001). Ion Channels of Excitable Membranes, Sinauer Associates. [3rd ed.].
2. Quantal components of the endplate potential10.1113/jphysiol.1954.sp005129 ↗
3. Fluctuating synaptic conductance recreate in vivo-like activity in neocortical neurons10.1016/S0306-4522(01)00344-X ↗
4. Limitations of the Hodgkin–Huxley formalism: Effect of single channel kinetics on transmembrane voltage dynamics10.1162/neco.1993.5.6.843 ↗
5. Spontaneous action potentials due to channel fluctuations10.1016/S0006-3495(96)79494-8 ↗
6. Analysis of the fluctuations in the inter-spike of abducens nucleus neurons during ocular fixations in the alert cat10.1016/0006-8993(86)90099-5 ↗
7. Computer simulation of the neural discharge carried by the abducens nerve during eye fixation in the cat10.1016/0020-7101(89)90031-7 ↗
8. Ion channel stochasticity may be critical in determining the reliability and precision of spike timing10.1162/089976698300017089 ↗
9. Pishro-Nik, H. (2014). Introduction to Probability, Statistics and Random Processes, Kappa Investigación, LLC.
10. Quantitative Analysis of IRT Variability during the First Training Stages of a Variable-Interval Schedule in Rats10.1007/BF03399601 ↗
11. A Competition Model of IRT Distributions during the First Training Stages of Variable-Interval Schedule10.1007/BF03399602 ↗
12. Timing and competition in networks representing ambiguous figures
13. Numerical exploration of the influence of neural noise on the psychometric function at low stimulation intensity levels10.1007/s12038-008-0094-8 ↗
14. Behavior needs neural variability10.1016/j.neuron.2021.01.023 ↗
15. The superstition experiment: A reexamination of its implications for the principles of adaptative behavior10.1037/h0030305 ↗
16. (1972). Laszlo, L The System View of the World, Braziller.
17. Gottman, J.M. (1981). Time-Series Analysis. A Comprehensive Introduction for Social Scientists, Cambridge University Press.
18. Johnson, N.I., and Kotz, S. (1970). Continuous Univariate Distributions-1, Houghton Mifflin Company.
19. Sokal, R.R., and Rohlf, F.S. (1981). Biometry, W. H. Freeman.
20. Random behavior, amplification processes and number of participants: How they contribute to the foraging properties of ants
21. Carpenter, R.H.S. (1977). Movements of the Eyes, Pion.
22. Minature eye movement10.1126/science.181.4102.810 ↗
23. Behavior of neurons in the abducens nucleus of the alert cat. I. Mononeurons10.1016/0306-4522(86)90072-2 ↗
24. The use of control systems analysis in the neurophysiology of eye movements10.1146/annurev.ne.04.030181.002335 ↗
25. Vision: A window on consciousness10.1038/scientificamerican1199-68 ↗
26. Binocular rivalry is not chaotic10.1098/rspb.1995.0011 ↗
27. Modelos conexionistas y sus propiedades
28. Sense and the single neuron: Probing the physiology of perception10.1146/annurev.neuro.21.1.227 ↗
29. Stochastic resonance and sensory information processing: A tutorial and review application10.1016/j.clinph.2003.09.014 ↗
30. A stochastic model of the electrically stimulated auditory nerve: Single-pulse response10.1109/10.764938 ↗
31. Energy, quanta and vision10.1085/jgp.25.6.819 ↗
32. Johanson, R.S., and Vallbo, A.B. (1976). Sensory Functions of the Skin in Primates, Pergamon.
33. Microstimulation in visual area M.T.: Effects on direction discrimination performance10.1523/JNEUROSCI.12-06-02331.1992 ↗
34. Visual attention modulates signal detectability10.1037/0096-1523.16.4.802 ↗
35. Subthreshold voltage noise due to channel fluctuations in active neuronal membranes10.1023/A:1008967807741 ↗
36. Postsynaptic inhibition can explain the concentration of short inter-spike-intervals in avian auditory nerve fibers10.1016/0378-5955(91)90108-L ↗
37. Development of activity patterns in auditory nerve fibres of pigeons10.1016/0378-5955(96)00020-2 ↗
38. Responses to single quanta of light in retinal ganglion cells of the cat10.1016/0042-6989(71)90033-2 ↗
39. Fractal ion channels behavior generates fractal firing patterns in neuronal models10.1103/PhysRevE.59.5970 ↗
40. Electrophysiological and morphological properties of rat abducens motoneurones10.1007/BF00253631 ↗
41. Darwin, C., and Kebler, L. (1859). On the Origin of Species by Means of Natural Selection, or, the Preservation of Favoured Races in the Struggle for Life, J. Murray.10.5962/bhl.title.68064 ↗
42. A Modification of Jerne’s Theory of Antibody Production using the Concept of Clonal Selection10.3322/canjclin.26.2.119 ↗
43. Neural Darwinism: Selection and reentrant signaling in higher brain function10.1016/0896-6273(93)90304-A ↗
44. Moment-to-moment brain signal variability: A next frontier in human brain mapping?10.1016/j.neubiorev.2013.02.015 ↗
45. Variability in neural activity and behavior10.1016/j.conb.2014.02.013 ↗