Translational Echocardiography: The Dog as a Clinical Research Model of Cardiac Dysfunction
Source abstract
Abstract
Heart disease is a major contributor to mortality and disability on a global scale. Hence, there is a need for research to improve non-invasive diagnostic techniques. Diseases in dogs with characteristics very similar to those of human pathologies hold promise as a source of data for evaluating and developing echocardiographic techniques and devices. Methods: We conducted a structured literature search from June 2022 to January 2023 to evaluate the relevance of dogs as a translational model for echocardiographic clinical research. We searched various academic databases, including PubMed Central (PMC), Core, DIGITAL.CSIC, DOAB, DOAJ, EBSCO host, Elsevier B.V, Redib, Scopus, and Web of Science, available through the Academic Information System of the Autonomous University of Baja California. Results: Out of the 243 articles initially screened, we identified 119 relevant articles that met our inclusion criteria for further analysis. This review is an introduction to the canine model by analyzing the cardiovascular anatomical similarities between the two species, the pathophysiological overlaps in some diseases, the parallels in echocardiographic techniques in dogs compared to humans, and the suitability of dogs with a naturally occurring cardiac disease as a model for translational clinical research compared to other animal species. Conclusions: This review emphasizes the importance of canine patients as an ideal cardiac disease symmetrical clinical model since they share common heart diseases with humans. Furthermore, dogs have a shorter lifespan, leading to the relatively rapid evolution of these diseases, which makes studying these pathologies and developing echocardiographic techniques more feasible. The results strongly indicate the need for interdisciplinary collaboration and translational medical research to create innovative echocardiographic technologies and improve the connection between veterinary and human cardiac imaging research.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Cardiovascular Conditions and Treatments · Cardiac Valve Diseases and Treatments · Congenital Heart Disease Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Veterinary Sciences Research Institute, Autonomous University of Baja California, Mexicali 21360, Baja California, Mexico
CVET, Veterinary Cardiology Services, Santiago 7910484, Chile
Albeitar Veterinary Hospital, Guadalajara 45640, Jalisco, Mexico
Veterinary Medicine and Zootechnics School, Autonomous University of Sinaloa, Culiacan 80260, Sinaloa, Mexico
References (100+)
Show source-provided references
1. The Global Burden of Cardiovascular Diseases and Risks10.1016/j.jacc.2020.11.021 ↗
2. Gaar-Humphreys, K.R., Spanjersberg, T.C.F., Santarelli, G., Grinwis, G.C.M., Szatmári, V., Roelen, B.A.J., Vink, A., van Tintelen, J.P., Asselbergs, F.W., and Fieten, H. (2022). Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model. Animals, 12.10.3390/ani12131679 ↗
3. Camacho, P., Fan, H., Liu, Z., and He, J.Q. (2016). Large Mammalian Animal Models of Heart Disease. J. Cardiovasc. Dev. Dis., 3.10.3390/jcdd3040030 ↗
4. Alternatives to animal testing in basic and preclinical research of atopic dermatitis10.1111/exd.13498 ↗
5. Cardiovascular imaging: What have we learned from animal models?10.3389/fphar.2015.00227 ↗
6. Demiris, G., Oliver, D.P., and Washington, K.T. (2019). Behavioral Intervention Research in Hospice and Palliative Care, Elsevier.10.1016/B978-0-12-814449-7.00001-6 ↗
7. Sisson, S., Grossman, J.D., and Getty, R. (1975). Sisson and Grossman’s: The Anatomy of the Domestic Animals, Saunders. [5th ed.].
8. Michaelsson, M., and Ho, S.Y. (2000). Congenital Heart Malformations in Mammals: An Illustrated Text, Imperial College Press.10.1142/p136 ↗
9. Anatomy of the pig heart: Comparisons with normal human cardiac structure10.1046/j.1469-7580.1998.19310105.x ↗
10. Morphometric assessment of canine heart without macroscopically visible changes caused by cardiac disease10.1590/1809-6891v19e-43748 ↗
11. Iaizzo, P. (2009). Handbook of Cardiac Anatomy, Physiology, and Devices, Humana Press.10.1007/978-1-60327-372-5 ↗
12. Structure and Anatomy of the Human Pericardium10.1016/j.pcad.2016.12.010 ↗
13. Miller, M.E., and Evans, H.E. (1993). Miller’s Anatomy of the Dog, Saunders. [3rd ed.].
14. The normal pericardium10.1016/0002-9149(70)90702-2 ↗
15. Correlation of structure and viscoelastic properties in the pericardia of four mammalian species
16. Spodick, D.H. (1997). The Pericardium: A Comprehensive Textbook, Dekker.
17. Evaluation of the Pericardium with CT and MR10.1155/2014/174908 ↗
18. Physical activity and cardiovascular aging: Physiological and molecular insights10.1016/j.exger.2017.05.016 ↗
19. Singh, B. (2017). Dyce, Sack, and Wensing’s Textbook of Veterinary Anatomy, Elsevier. [5th ed.].
20. Anatomy of human mitral valve in adult cadaver and comparative anatomy of the valve10.1136/hrt.40.4.351 ↗
21. Tarniceriu, C.C., Hurjui, L.L., Tanase, D.M., Nedelcu, A.H., Gradinaru, I., Ursaru, M., Stefan Rudeanu, A., Delianu, C., and Lozneanu, L. (2021). The Pulmonary Venous Return from Normal to Pathological—Clinical Correlations and Review of Literature. Medicina, 57.10.3390/medicina57030293 ↗
22. Reconstruction of fibrous skeleton: Technique, pitfalls and results10.1093/mmcts/mmu004 ↗
23. Morphologic variability of the mitral valve leaflets10.1016/j.jtcvs.2017.07.067 ↗
24. Computed tomography and magnetic resonance imaging of the coronary sinus: Anatomic variants and congenital anomalies10.1007/s13244-014-0330-8 ↗
25. Bigler, M.R., and Seiler, C. (2019). The Human Coronary Collateral Circulation, Its Extracardiac Anastomoses and Their Therapeutic Promotion. Int. J. Mol. Sci., 20.10.3390/ijms20153726 ↗
26. The coronary collateral circulation: Genetic and environmental determinants in experimental models and humans10.1016/j.yjmcc.2011.09.010 ↗
27. Dynamic changes of mitral valve annulus geometry at preprocedural CT: Relationship with functional classes of regurgitation10.1186/s41747-021-00231-3 ↗
28. Current status of the treatment of degenerative mitral valve regurgitation10.1016/j.repc.2020.10.011 ↗
29. Myxomatous degeneration of the mitral valve10.4322/acr.2018.058 ↗
30. Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms10.1016/j.carpath.2019.107196 ↗
31. Correlation between heart valve interstitial cell stiffness and transvalvular pressure: Implications for collagen biosynthesis10.1152/ajpheart.00521.2005 ↗
32. Surface strains in the anterior leaflet of the functioning mitral valve10.1114/1.1529194 ↗
33. Anatomy of the mitral valve: Understanding the mitral valve complex in mitral regurgitation10.1093/ejechocard/jeq153 ↗
34. Pathology of myxomatous mitral valve disease in the dog10.1016/j.jvc.2012.02.001 ↗
35. Myxomatous degeneration of the canine mitral valve: From gross changes to molecular events10.1016/j.jcpa.2017.01.009 ↗
36. Fibrous skeleton of the heart: Anatomic overview and evaluation of pathologic conditions with CT and MR imaging10.1148/rg.2017170004 ↗
37. Effects of a saddle shaped annulus on mitral valve function and chordal force distribution: An in vitro study10.1114/1.1616929 ↗
38. Saddle shape of the mitral annulus reduces systolic strains on the P2 segment of the posterior mitral leaflet10.1016/j.athoracsur.2009.06.042 ↗
39. Differentiating the aging of the mitral valve from human and canine myxomatous degeneration10.1016/j.jvc.2011.11.003 ↗
40. Pathology, protein expression and signaling in myxomatous mitral valve degeneration: Comparison of dogs and humans10.1016/j.jvc.2012.01.005 ↗
41. Heart valve development: Regulatory networks in development and disease10.1161/CIRCRESAHA.109.201566 ↗
42. Heart valve biomechanics and underlying mechanobiology10.1002/cphy.c150048 ↗
43. Burden of valvular heart diseases: A population-based study10.1016/S0140-6736(06)69208-8 ↗
44. Functional anatomy and pathophysiologic principles in mitral regurgitation: Non-invasive assessment10.1016/j.pcad.2017.11.008 ↗
45. Aluru, J.S., Barsouk, A., Saginala, K., Rawla, P., and Barsouk, A. (2022). Valvular Heart Disease Epidemiology. Med. Sci., 10.10.3390/medsci10020032 ↗
46. Epidemiology of valvular heart disease in the adult10.1038/nrcardio.2010.202 ↗
47. Historical review, epidemiology and natural history of degenerative mitral valve disease10.1016/j.jvc.2012.01.011 ↗
48. Myxomatous mitral valve disease in dogs: Does size matter?10.1016/j.jvc.2012.01.006 ↗
49. Longevity and mortality in Kennel Club registered dog breeds in the UK in 201410.1186/s40575-018-0066-8 ↗
50. Bagardi, M., Bionda, A., Locatelli, C., Cortellari, M., Frattini, S., Negro, A., Crepaldi, P., and Brambilla, P.G. (2020). Echocardiographic Evaluation of the Mitral Valve in Cavalier King Charles Spaniels. Animals, 10.10.3390/ani10091454 ↗
51. Mitral valve prolapse in Cavalier King Charles spaniel: A review and case study10.4142/jvs.2005.6.1.67 ↗
52. Mitral regurgitation in the 21st century10.1016/j.pcad.2017.11.007 ↗
53. Guidelines for the diagnosis and treatment of canine chronic valvular heart disease10.1111/j.1939-1676.2009.0392.x ↗
54. Survival characteristics and prognostic variables of dogs with preclinical chronic degenerative mitral valve disease attributable to myxomatous degeneration10.1111/j.1939-1676.2011.00860.x ↗
55. ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs10.1111/jvim.15488 ↗
56. Boon, J.A. (1998). Manual of Veterinary Echocardiography, Williams and Wilkins. [1st ed.].
57. Comparison of 3 ultrasound methods for quantifying left ventricular systolic function: Correlation with disease severity and prognostic value in dogs with mitral valve disease10.1111/j.1939-1676.2008.0097.x ↗
58. Can ventricular function be assessed by echocardiography in chronic canine mitral valve disease?10.1111/j.1748-5827.2009.00803.x ↗
59. Advanced techniques in echocardiography in small animals10.1016/j.cvsm.2010.03.007 ↗
60. Suh, S.-I., Lu, T.-L., Choi, R., and Hyun, C. (2021, January 25). Echocardiographic Features in Canine Myxomatous Mitral Valve Disease: An Animal Model for Human Mitral Valve Prolapse. Proceedings of the Advanced Concepts in Endocarditis-2021, Virtual.10.5772/intechopen.91819 ↗
61. Scientific document Committee of the European Association of cardiovascular imaging: Recommendations for the echocardiographic assessment of native valvular regurgitation: An executive summary from the European Association of Cardiovascular Imaging10.1093/ehjci/jet105 ↗
62. Quantification of mitral valve regurgitation in dogs with degenerative mitral valve disease by use of the proximal isovelocity surface area method10.2460/javma.231.3.399 ↗
63. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography10.1016/S0894-7317(03)00335-3 ↗
64. Echocardiographic assessment of canine degenerative mitral valve disease10.1016/j.jvc.2011.11.005 ↗
65. Association of plasma N-terminal pro-B-type natriuretic peptide concentration with mitral regurgitation severity and outcome in dogs with asymptomatic degenerative mitral valve disease10.1111/j.1939-1676.2009.0347.x ↗
66. Regurgitant jet area by Doppler color flow mapping: Quantitative assessment of mitral regurgitation severity in dogs10.1016/S1760-2734(06)70050-9 ↗
67. Echocardiographic predictors of survival in dogs with myxomatous mitral valve disease10.1016/j.jvc.2014.11.001 ↗
68. Quantitation of mitral regurgitation10.1161/CIRCULATIONAHA.112.121590 ↗
69. Recommendations for non-invasive evaluation of native Valvular regurgitation: A report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance10.1016/j.echo.2017.01.007 ↗
70. The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs10.1111/jvim.16131 ↗
71. Assessment of mitral regurgitation in dogs: Comparison of results of echocardiography with magnetic resonance imaging10.1111/jsap.12410 ↗
72. Reproducibility of proximal isovelocity surface area, vena contracta, and regurgitant jet area for assessment of mitral regurgitation severity10.1016/j.jcmg.2009.09.029 ↗
73. Proximal isovelocity surface area variability during systole in dogs with mitral valve prolapse10.1016/j.jvc.2011.08.003 ↗
74. Real-time 3-dimensional echocardiographic assessment of effective regurgitant orifice area in dogs with myxomatous mitral valve disease10.1111/jvim.14642 ↗
75. Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease10.1111/j.1939-1676.2007.0008.x ↗
76. Left atrial to aortic root indices using two-dimensional and M-mode echocardiography in cavalier King Charles spaniels with and without left atrial enlargement10.1111/j.1740-8261.2002.tb01051.x ↗
77. Allometric scaling of M-mode cardiac measurements in normal adult dogs10.1111/j.1939-1676.2004.tb02551.x ↗
78. Detection of congestive heart failure in dogs by Doppler echocardiography10.1111/j.1939-1676.2010.0592.x ↗
79. Effect of pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: The EPIC study—A randomized clinical trial10.1111/jvim.14586 ↗
80. Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: The PREDICT cohort study10.1016/j.jvc.2012.01.008 ↗
81. Left ventricular remodeling in preclinical experimental mitral regurgitation of dogs10.1016/j.jvc.2012.01.012 ↗
82. Menciotti, G., and Borgarelli, M. (2017). Review of Diagnostic and Therapeutic Approach to Canine Myxomatous Mitral Valve Disease. Vet. Sci., 4.10.3390/vetsci4040047 ↗
83. Impaired contractile reserve in severe mitral valve regurgitation with a preserved ejection fraction10.1016/j.ejheart.2007.05.013 ↗
84. Prognostic value of echocardiographic indices of left atrial morphology and function in dogs with myxomatous mitral valve disease10.1111/jvim.15093 ↗
85. Multi-modality imaging assessment of native valvular regurgitation: An EACVI and ESC council of valvular heart disease position paper10.1093/ehjci/jeab253 ↗
86. Assessment of mitral regurgitation severity by Doppler color flow mapping of the vena contracta in dogs10.1111/jvim.12380 ↗
87. Mitral valve prolapse in the dog: A model of mitral valve prolapse in man10.1016/S0008-6363(00)00113-9 ↗
88. Prognostic value of left atrial function in dogs with chronic mitral valvular heart disease10.1111/jvim.12441 ↗
89. Echocardiographic anatomy of the mitral valve in healthy dogs and dogs with myxomatous mitral valve disease10.1016/j.jvc.2015.01.003 ↗
90. Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease10.1016/j.jvc.2012.01.009 ↗
91. Rate of left ventricular pressure change by Doppler echocardiography in dogs with chronic mitral valve disease at different stages of congestive heart failure10.1111/vru.12664 ↗
92. Chetboul, V., Bussadori, C., and De Madron, É. (2016). Clinical Echocardiography of the Dog and Cat, Elsevier.
93. Retrospective study of degenerative mitral valve disease in small-breed dogs: Survival and prognostic variables10.4142/jvs.2017.18.3.369 ↗
94. Usefulness of conventional and tissue Doppler echocardiography to predict congestive heart failure in dogs with myxomatous mitral valve disease10.1111/jvim.12466 ↗
95. E/e’ Ratio in Patients with Unexplained Dyspnea: Lack of Accuracy in Estimating Left Ventricular Filling Pressure10.1161/CIRCHEARTFAILURE.115.002161 ↗
96. Rutland, C. (2021). Canine Genetics, Health and Medicine, IntechOpen. Available online: https://www.intechopen.com/chapters/76601.10.5772/intechopen.92513 ↗
97. Heart Disease as a Cause of Death in Insured Swedish Dogs Younger than 10 Years of Age10.1111/j.1939-1676.2006.tb01803.x ↗
98. Mortality in north american dogs from 1984 to 2004: An investigation into age-, size-, and breed-related causes of death10.1111/j.1939-1676.2011.0695.x ↗
99. Mathers, C.D., and Loncar, D. (2006). Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med., 3.10.1371/journal.pmed.0030442 ↗
100. Mausberg, T.B., Wess, G., Simak, J., Keller, L., Drögemüller, M., Drögemüller, C., Webster, M.T., Stephenson, H., Dukes-McEwan, J., and Leeb, T. (2011). A locus on chromosome 5 is associated with dilated cardiomyopathy in Doberman Pinschers. PLoS ONE, 6.10.1371/journal.pone.0020042 ↗