Folic Acid/Methotrexate Functionalized Mesoporous Silica Nanoflakes from Different Supports: Comparative Study
Source abstract
Abstract
Herein, we present a facile synthesis route for the mesoporous silica nanoflakes on two types of templates and evaluate their potential as potential drug delivery systems. Silica materials are attractive due to their biocompatibility, low cytotoxicity, high surface area, and tunable pores. In addition, they can be multifunctionalized. These properties were used to create multifunctional drug delivery systems combining folic acid as a target molecule and methotrexate (MTX) as an anticancer drug. The silica nanoflakes were formed using graphene oxide and double-layered hydroxide as templates, respectively. After the removal of matrices, the silica flakes were functionalized by folic acid and loaded with methotrexate. The differences in drug release performance and structural stability were analyzed with respect to the detailed physicochemical characterization of the produced silica nanoflakes.
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Research context
OpenAlex topics: Mesoporous Materials and Catalysis · Graphene and Nanomaterials Applications · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Nanomaterials Physicochemistry, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology, Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland
Department of Integrated Transport Technology and Environmental Protection, Maritime University of Szczecin, H. Pobożnego St. 11, 70-507 Szczecin, Poland
Funding
Narodowe Centrum Nauki
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