Experimental Study of Electrical Properties of Pharmaceutical Materials by Electrical Impedance Spectroscopy
Source abstract
Abstract
The physicochemical characterization of pharmaceutical materials is essential for drug discovery, development and evaluation, and for understanding and predicting their interaction with physiological systems. Amongst many measurement techniques for spectroscopic characterization of pharmaceutical materials, Electrical Impedance Spectroscopy (EIS) is powerful as it can be used to model the electrical properties of pure substances and compounds in correlation with specific chemical composition. In particular, the accurate measurement of specific properties of drugs is important for evaluating physiological interaction. The electrochemical modelling of compounds is usually carried out using spectral impedance data over a wide frequency range, to fit a predetermined model of an equivalent electrochemical cell. This paper presents experimental results by EIS analysis of four drug formulations (trimethoprim/sulfamethoxazole C14H18N4O3-C10H11N3O3, ambroxol C13H18Br2N2O.HCl, metamizole sodium C13H16N3NaO4S, and ranitidine C13H22N4O3S.HCl). A wide frequency range from 20 Hz to 30 MHz is used to evaluate system identification techniques using EIS data and to obtain process models. The results suggest that arrays of linear R-C models derived using system identification techniques in the frequency domain can be used to identify different compounds.
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Research context
OpenAlex topics: Analytical Chemistry and Sensors · Electrical and Bioimpedance Tomography · Microfluidic and Capillary Electrophoresis Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Tecnológico Nacional de México/Instituto Tecnológico de Morelia, División de Estudios de Posgrado E Investigación, Avenida Tecnológico 1500, Morelia C. P 58120, Michoacán, Mexico
Department of Electrical and Electronic Engineering, The University of Manchester, Manchester M13 9PL, UK
CINVESTAV/IPN, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, México C.P 07360, D. F., Mexico
Funding
Consejo Nacional de Ciencia y Tecnología · Michoacán State´s Institute for Sciencie, Technology and Innovation
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