The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging
Source abstract
Abstract
The most notable obstacle of brain cancer diagnosis is the inability of delivering imaging agents across the blood-brain barrier (BBB). Recently, quantum dots (QDs) has been demonstrated as an ideal image agent for brain imaging due to their ultra-small size for crossing BBB. The plolyamidoamine dendrimers modified CdTe/CdS core/shell near-infrared (NIR) region QDs was successfully synthesized in aqueous solution, and then was characterized by UV-vis absorption, photoluminescence (PL) spectroscopy, dynamic light scattering (DLS), X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM), etc. Our results reveal that the dendrimers modified CdTe/CdS QDs exhibits good water-dispersity and stable NIR fluorescence in various biological environments. In addition, this NIR QDs demonstrates a good biocompatibility and sensitive photoluminescence responses in brain tumor cell imaging. In a word, this type of dendrimers modified NIR CdTe/CdS QDs has huge potential applications in brain imaging.
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Research context
OpenAlex topics: Quantum Dots Synthesis And Properties · Nanocluster Synthesis and Applications · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Neurology, Pudong People’s Hospital, Shanghai 201299, China
Department of Radiology, Pudong People’s Hospital, Shanghai 201299, China
References (14)
Show source-provided references
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