Microwave-Assisted Synthesis and Antifungal Activity of Some Novel Thioethers Containing 1,2,4-Triazole Moiety
Source abstract
Abstract
A series of novel thioether derivatives containing 1,2,4-triazole moiety were designed and synthesized from 4-chlorophenol and ethyl 2-chloroacetate as starting materials by multi-step reactions under microwave irradiation, and their structures were characterized by 1H-NMR, MS and elemental analysis. The antifungal activity of title compounds was determined. The results indicated that some of title compounds exhibited moderate antifungal activity.
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Research context
OpenAlex topics: Synthesis and biological activity · Microwave-Assisted Synthesis and Applications · Synthesis and Characterization of Heterocyclic Compounds
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Life Science, Huzhou University, Huzhou 313000, China
Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100014, China
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
Ecology Institute of Shandong Academy of Science, Jinan 250014, China
References (33)
Show source-provided references
1. Synthesis and antifungal activity of 1,2,3-thiadiazole derivatives containing 1,3,4-thiadiazole moiety10.2174/1570180811666140423222141 ↗
2. Synthesis and antifungal activity of 3-aryl-1,2,4-triazin-6-one derivatives10.1002/ps.3765 ↗
3. Synthesis and antifungal activity of 1,3,4-thiadiazole derivatives containing pyridine group10.2174/1570180811666140610212731 ↗
4. Expanding the structure-activity relationship of sulfoxaflor: The synthesis and biological activity of N-heterocyclic sulfoximines10.1002/ps.3865 ↗
5. Synthesis, dimeric crystal, and fungicidal activity of 1-(4-methylphenyl)-2-(5-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio) ethanone10.1080/10426507.2010.508060 ↗
6. Synthesis, biological activities and SAR studies of novel 1-ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid based diacyl and sulfonyl acyl hydrazines10.1002/ps.3650 ↗
7. Phase transfer-catalyzed, one-potsynthesis of some novel N-pyrimidinyl-N′-picotinylthioureaderivatives10.1080/10426507.2010.508059 ↗
8. A facile one-pot synthesis of novel 1,2,4-triazolo[4,3-a]pyridine derivativescontaining the trifluoromethyl moiety using microwave irradiation10.3184/174751915X14400874295745 ↗
9. Microwave-assisted synthesis of novel fluorinated 1,2,4-triazole derivatives, and study of their biological activity10.1007/s11164-013-1113-4 ↗
10. Microwave-assisted synthesis of novel 8-chloro-[1,2,4]triazolo[4,3-a]pyridinederivatives10.3906/kim-1408-78 ↗
11. Synthesis and anti-inflammatory activity of new 1,2,4-triazole derivatives10.1016/j.bmcl.2015.04.079 ↗
12. Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids10.3390/molecules20046254 ↗
13. Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties10.3390/ijms150610908 ↗
14. Synthesis of Novel Triazoles, Tetrazine, Thiadiazoles and Their Biological Activities10.3390/molecules20022591 ↗
15. Synthesis, crystal structure, herbicidal activities and 3D-QSAR study of some novel 1,2,4-triazolo[4,3-a]pyridine derivatives10.1002/ps.3804 ↗
16. Synthesis, crystal structure and antifungal activity of 4-(5-((2,4-dichlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine
17. Microwave assistant one pot synthesis, crystal structure, antifungal activities and 3D-QSAR of novel 1,2,4-triazolo[4,3-a]pyridines10.1111/cbdd.12323 ↗
18. Synthesis, Antibacterial, Antiurease, and Antioxidant Activities of Some New 1,2,4-Triazole Schiff Base and Amine Derivatives10.1007/s12010-014-1307-2 ↗
19. Synthesis and antidepressant activity of di substituted-5-aryl-1,2,4-triazoles10.1007/s00044-011-9902-z ↗
20. Design, synthesis, biological activities, and 3D-QSAR of new N,N′-diacylhydrazines containing 2-(2,4-dichlorophenoxy)propane moiety10.1111/j.1747-0285.2011.01205.x ↗
21. Alkylsulfanyl-1,2,4-Triazoles, a New Class of Allosteric Valosine Containing Protein Inhibitors. Synthesis and Structure-Activity Relationships10.1021/jm3013213 ↗
22. Discovery of non-glucoside SGLT2 inhibitors10.1016/j.bmcl.2011.02.056 ↗
23. Microwave assisted synthesis, antifungal activity and DFT theoretical study of some novel 1,2,4-triazole derivatives containing the 1,2,3-thiadiazole moiety10.3390/molecules181012725 ↗
24. Microwave assistant synthesis, antifungal activity and DFT theoretical study of some novel 1,2,4-triazole derivatives containing pyridine moiety10.3390/ijms15058075 ↗
25. Synthesis of 1,2,4-Triazole-3-Thiols and Their S-Substituted Derivatives10.1134/S1070428010040184 ↗
26. Facile and efficient synthesis and herbicidal activity determination of novel 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one derivatives via microwave irradiation10.1016/j.bmcl.2015.10.064 ↗
27. Progress in microwave-aided chemical synthesis10.1071/CH12366 ↗
28. Synthesis, Crystal Structure and DFT Studies of 8-chloro-3-((3-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine10.3390/cryst5040491 ↗
29. Greener and Sustainable Approaches to the Synthesis of Pharmaceutically Active Heterocycles
30. Greener and Expeditious Synthesis of Bio-Active Heterocycles using Microwave Irradiation10.1351/pac200880040777 ↗
31. Facile and efficient synthesis of novel 1,2,3-thiadiazole derivatives using microwave irradiation10.3184/174751915X14326308763971 ↗
32. Synthesis and Biological Activity of Acylthiourea Derivatives Contain 1,2,3-Thiadiazole and 1,3,4-Thiadiazole10.2174/1570180811666141010000435 ↗
33. Synthesis, crystal structure and fungicidal activity of a novel 1,2,3-thiadiazole compound10.1080/10426507.2012.664219 ↗