Selenium Deficiency—From Soil to Thyroid Cancer
Source abstract
Abstract
Selenium (Se) is an essential micronutrient present in human diet, entering in the composition of selenoproteins as selenocysteine (Se-Cys) amino acid. At the thyroid level, these proteins play an important role as antioxidant and in hormone metabolism. Selenoproteins are essential for the balance of redox homeostasis and antioxidant defense of mammalian organisms, while the corresponding imbalance is now recognized as the cause of many diseases including cancer. The food chain is the main source of Se in human body. Dietary intake is strongly correlated with Se content in soil and varies according to several factors such as geology and atmospheric input. Both Se deficiency and toxicity have been associated with adverse health effects. This review synthesizes recent data on the transfer of Se from soil to humans, Se U-shaped deficiency and toxicity uptake effects and particularly the impact of Se deficiency on thyroid cancer.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Selenium in Biological Systems · Heavy Metal Exposure and Toxicity · Trace Elements in Health
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
ISTerre, University of Grenoble-Alpes and CNRS, BP 53, 38041 Grenoble CEDEX 9, France
Analytical Chemistry and Electrochemistry Laboratory, Abou Bekr BELKAID University of Tlemcen, Tlemcen 13000, Algeria
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