Comparisons of Halogenated β-Nitrostyrenes as Antimicrobial Agents
Source abstract
Abstract
The influence of three types of halogen-substituted E-β-methyl-β-nitrostyrenes (such as Compounds B, D, H) to overcome bacterial activity that is currently a significant health threat was studied. The evaluations of their bio-potency was measured and related to their structure and activity relationships for the purposes of serving to inhibit and overcoming resistant microorganisms. In particular, fluorine-containing β-nitrostyrenes were found to be highly active antimicrobial agents. The addition of the β-bromo group enhanced the antibacterial activity significantly. Our work has illustrated that halogen substituents at both the 4-position in the aromatic ring and also at the β-position on the alkene side chain of nitropropenyl arenes enhanced the antimicrobial activity of these compounds.
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Research context
OpenAlex topics: Organic Chemistry Cycloaddition Reactions · Oxidative Organic Chemistry Reactions · Bioactive Compounds and Antitumor Agents
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Health Innovations Research Institute & School of Applied Sciences RMIT University, Melbourne, VIC 3001, Australia
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