journal article·2025-10-02Open access

Screening of 31 Lactic Acid Bacteria Strains Identified Levilactobacillus brevis NCTC 13768 as a High-Yield GABA Producer

Desislava Teneva, Daniela Pencheva, Tsvetanka Teneva-Angelova, Svetla Danova, Nikoleta Atanasova, Lili Dobreva, Manol Ognyanov, Ani Petrova, Aleksandar Slavchev, Vasil Georgiev, Petko Denev

Applied Sciences· Volume 15· Issue 19

Abstract

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate central nervous system, known for its role in promoting sleep, reducing anxiety, regulating blood pressure, and modulating stress, cognition, and behavior. Microbial fermentation offers an effective method for GABA production, with certain lactic acid bacteria (LAB) strains recognized as efficient producers. This study assessed the GABA-producing potential of 31 LAB strains, including isolates from traditional Bulgarian foods and plants. The strains were cultivated in an MRS medium supplemented with 1% monosodium glutamate (MSG), and GABA production was quantified using HPLC after derivatization with dansyl chloride. Most strains produced between 200 and 300 mg/L of GABA. However, Levilactobacillus brevis NCTC 13768 showed much higher productivity, reaching 3830.7 mg/L. To further evaluate its capacity, L. brevis NCTC 13768 was cultivated for 168 h in MRS medium with and without MSG. Without MSG, GABA production peaked at 371.0 mg/L during the late exponential phase. In contrast with MSG, GABA levels steadily increased, reaching 3333.6 mg/L after 168 h. RT-qPCR analyses of the glutamic acid decarboxylase (GAD) system showed that the genes of glutamate decarboxylase (gadB), glutamate-GABA antiporter (gadC), and transcriptional regulator (gadR) are significantly overexpressed when the culture reaches the late stationary phase of growth (96 h after the beginning of cultivation). These results identify L. brevis NCTC 13768 as a high-yield GABA producer, with potential applications in the production of fermented functional foods and beverages.
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Research context

OpenAlex topics: GABA and Rice Research · Probiotics and Fermented Foods · Medicinal Plants and Neuroprotection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Biologically Active Substances, Plovdiv, Institute of Organic Chemistry with the Centre of Phytochemistry, Bulgarian Academy of Sciences, 4000 Plovdiv, Bulgaria

Centre of Competence “Sustainable Utilization of Bio-Resources and Waste of Medicinal and Aromatic Plants for Innovative Bioactive Products” (BIORESOURCES BG), 1000 Sofia, Bulgaria

Laboratory Cell Biosystems, Department of Biotechnology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 4000 Plovdiv, Bulgaria

Laboratory Lactic Acid Bacteria and Probiotics, Department of General Microbiology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

Department of Microbiology and Biotechnology, University of Food Technology, 4002 Plovdiv, Bulgaria

Funding

Bulgarian National Science Fund

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