Functional Food as a Nutritional Countermeasure to Health Risks from Microgravity and Space Radiation in Long-Term Spaceflights: A Review
Source abstract
Abstract
(1) Background: Over the years, technology and space missions have advanced, although the development of potential functional food and food supplements must be improved for maintaining astronauts’ health and helping them overcome space-specific challenges during long missions. (2) Scope and approach: Using a review approach, this study aimed to investigate the potential of functional food to counteract radiation and microgravity spaceflight-related health problems. (3) Results: Microgravity and space radiation affect the body’s biochemical processes and increase levels of reactive oxygen species, which may lead to health problems, including musculoskeletal deconditioning, cardiovascular degeneration, disruptions in gastrointestinal health, ocular problems, alterations to the immune system, and hormonal imbalances, among others. In addition to medical care, functional food plays a key role as a countermeasure against space-induced physiological issues. Previous research showed that functional food rich in flavonoids, omega-3 fatty acids, vitamins, minerals, antioxidant compounds, proteins, probiotics, or prebiotics strengthens the immune system and reduces risks associated with long spaceflights, such as bone density loss, muscle atrophy, oxidative stress, and other health alterations. (4) Conclusions: Despite the fundamental role of functional food in spaceflights, the main challenges remain in preserving and packaging these foods to ensure their safety on long space missions. Future innovations include 3D food printing, space algae cultivation, and novel preservation technologies.
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Research context
OpenAlex topics: Spaceflight effects on biology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Grupo de Investigación Calidad y Seguridad Alimentaria, Instituto de Investigación e Innovación Agroalimentaria y Agroambiental (CIAGRO-UMH), Universidad Miguel Hernández de Elche, Carretera de Beniel, km 3.2, 03312 Orihuela, Alicante, Spain
References (99)
Show source-provided references
1. Prado, C.G. (2019). How Technology Is Changing Human Behavior: Issues and Benefits, Praeger. [1st ed.].10.5040/9798400666711 ↗
2. Anderson, R.M. (2022). The Evolution of Life: Big Bang to Space Colonies, Precocity Press.
3. Sgobba, T., Kanki, B., Clervoy, J.-F., and Sandal, G.M. (2018). Chapter 16—Selection and training. Space Safety and Human Performance, Butterworth-Heinemann.10.1016/B978-0-08-101869-9.00016-9 ↗
4. Johnson, L., and Roy, K. (2024). Chapter 3—Crew health—Psychological, biological, and medical issues and the need for a systems approach. Interstellar Travel, Elsevier.
5. Space-brain: The negative effects of space exposure on the central nervous system10.4103/sni.sni_250_17 ↗
6. Long term food stability for extended space missions: A review
7. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews10.1186/s13643-021-01626-4 ↗
8. Space nutrition and the biochemical changes caused in Astronauts Health due to space flight: A review10.1016/j.fochx.2023.100875 ↗
9. Food systems for long-term spaceflight: Understanding the role of non-nutrient polyphenols in astronauts’ health10.1016/j.heliyon.2024.e37452 ↗
10. Smith, J.K. (2020). Osteoclasts and Microgravity. Life, 10.10.20944/preprints202007.0714.v1 ↗
11. Genah, S., Monici, M., and Morbidelli, L. (2021). The Effect of Space Travel on Bone Metabolism: Considerations on Today’s Major Challenges and Advances in Pharmacology. Int. J. Mol. Sci., 22.10.3390/ijms22094585 ↗
12. Interventions to prevent bone loss in astronauts during space flight10.2302/kjm.54.55 ↗
13. Disuse of the musculo-skeletal system in space and on earth10.1007/s00421-010-1556-x ↗
14. Protein and Essential Amino Acids to Protect Musculoskeletal Health during Spaceflight: Evidence of a Paradox?10.3390/life4030295 ↗
15. Krittanawong, C. (2025). Chapter 30—Cardiovascular diseases in spaceflight. Precision Medicine for Long and Safe Permanence of Humans in Space, Academic Press.
16. Cardiovascular adaptations in microgravity conditions
17. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight10.1126/science.aau8650 ↗
18. Cardiac Effects of Repeated Weightlessness During Extreme Duration Swimming Compared with Spaceflight10.1161/CIRCULATIONAHA.120.050418 ↗
19. Long-term spaceflight and the cardiovascular system10.1093/pcmedi/pbaa022 ↗
20. Cardiac arrhythmias during long-duration spaceflights10.1016/j.joa.2013.07.009 ↗
21. Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars10.1038/s41526-020-00124-6 ↗
22. Cardiovascular changes under the microgravity environment and the gut microbiome
23. Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development10.1210/jendso/bvz039 ↗
24. Tesei, D., Jewczynko, A., Lynch, A.M., and Urbaniak, C. (2022). Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions. Life, 12.10.3390/life12040495 ↗
25. Altered fecal microbiomes and short chain fatty acids of crew members with periodic intake of prepackaged food in a ground-based space station simulator for 50 days10.1016/j.tmaid.2019.101480 ↗
26. Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement10.1016/j.csbj.2021.03.040 ↗
27. Microbiological status of cosmonauts during orbital spaceflights on Salyut and Mir orbital stations10.1016/j.actaastro.2005.01.009 ↗
28. Jiang, P., Green, S.J., Chlipala, G.E., Turek, F.W., and Vitaterna, M.H. (2019). Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight. Microbiome, 7.10.1186/s40168-019-0724-4 ↗
29. The influence of simulated weightlessness on the composition and function of gut microbiota and bile acid metabolism products
30. NASA study of cataract in astronauts (NASCA). Report 1: Cross-sectional study of the relationship of exposure to space radiation and risk of lens opacity10.1667/RR1580.1 ↗
31. Radiation-induced cataract in astronauts and cosmonauts10.1007/s00417-002-0489-4 ↗
32. Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: A review and an update10.1038/s41526-020-0097-9 ↗
33. Spaceflight associated neuro-ocular syndrome: Proposed pathogenesis, terrestrial analogues, and emerging countermeasures10.1136/bjo-2022-322892 ↗
34. Dynamic visual acuity as a biometric for astronaut performance and safety
35. Neurostimulation as a technology countermeasure for dry eye syndrome in astronauts
36. Microgravity: The immune response and bone10.1111/j.0105-2896.2005.00330.x ↗
37. Space flight and the immune system10.1016/0264-410X(93)90217-L ↗
38. Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station10.1016/j.jacig.2024.100244 ↗
39. The response of endocrine system to stress loads during space flight in human subject10.1016/S0273-1177(03)00097-8 ↗
40. Krittanawong, C. (2025). Chapter 8—Metabolic adaptations to microgravity. Precision Medicine for Long and Safe Permanence of Humans in Space, Academic Press.
41. Effects of sex and gender on adaptations to space: Reproductive health10.1089/jwh.2014.4915 ↗
42. The effect of space travel on human reproductive health: A systematic review10.1038/s41526-024-00351-1 ↗
43. Adaptation of the human endocrine system to microgravity in the context of integrative physiology and ageing10.1007/s004240000331 ↗
44. Changes in stress hormones and metabolism during a 105-day simulated Mars mission10.3357/ASEM.3907.2014 ↗
45. Aging-like metabolic and adrenal changes in microgravity: State of the art in preparation for Mars10.1016/j.neubiorev.2021.01.028 ↗
46. Krittanawong, C. (2025). Chapter 21—Spaceflight implications for precision medicine in the field of obstetrics and gynecology and its subspecialties. Precision Medicine for Long and Safe Permanence of Humans in Space, Academic Press.
47. Mathyk, B.A., Tabetah, M., Karim, R., Zaksas, V., Kim, J., Anu, R.I., Muratani, M., Tasoula, A., Singh, R.S., and Chen, Y.-K. (2024). Spaceflight induces changes in gene expression profiles linked to insulin and estrogen. Commun. Biol., 7.10.1038/s42003-023-05213-2 ↗
48. The effects of real and simulated microgravity on cellular mitochondrial function10.1038/s41526-021-00171-7 ↗
49. Oxidative stress, neuroinflammation, and the blood-brain barrier biomarkers on the brain response to spaceflight
50. Miller, K.B., Mi, K.L., Nelson, G.A., Norman, R.B., Patel, Z.S., and Huff, J.L. (2022). Ionizing radiation, cerebrovascular disease, and consequent dementia: A review and proposed framework relevant to space radiation exposure. Front. Physiol., 13.10.3389/fphys.2022.1008640 ↗
51. Biological activity and toxicity of plant nutraceuticals: An overview10.1016/j.cofs.2021.05.008 ↗
52. Nutraceutical tablets: Manufacturing processes, quality assurance, and effects on human health10.1016/j.foodres.2024.115197 ↗
53. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men10.3945/ajcn.110.008102 ↗
54. Dijk, F.J., Hofman, Z., Luiking, Y.C., Furber, M.J.W., Roberts, J.D., van Helvoort, A., and van Dijk, M. (2023). Muscle Protein Synthesis with a Hybrid Dairy and Plant-Based Protein Blend (P4) Is Equal to Whey Protein in a Murine Ageing Model after Fasting. Nutrients, 15.10.3390/nu15112569 ↗
55. Vitamine K et physiologie osseuse10.1016/j.cnd.2009.03.005 ↗
56. Sarkar, T., Smaoui, S., and Petkoska, A.T. (2025). Chapter 12—Functional foods for bone and joint health: Building a solid foundation. Unleashing the Power of Functional Foods and Novel Bioactives, Academic Press.
57. Osteogenic peptides in bone regeneration10.2174/1381612811319190006 ↗
58. Sarkar, T., Smaoui, S., and Petkoska, A.T. (2025). Chapter 3—Functional foods for cardiovascular health: Nurturing a strong heart. Unleashing the Power of Functional Foods and Novel Bioactives, Academic Press.
59. Impacts of prebiotic diet and altered gravity on mouse immune response, gut microbiome, and home cage behavior10.1016/j.bbi.2024.01.102 ↗
60. Harnessing functional food strategies for the health challenges of space travel—Fermented soy for astronaut nutrition10.1016/j.actaastro.2010.08.023 ↗
61. Response of Lactobacillus acidophilus ATCC 4356 to low-shear modeled microgravity10.1016/j.actaastro.2017.07.033 ↗
62. Functional foods for astronauts: Enhancing health and performance in microgravity and extreme environments10.1016/j.spaceh.2025.100005 ↗
63. Zinc and the Eye10.1080/07315724.2001.10719022 ↗
64. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease10.1016/j.preteyeres.2015.10.003 ↗
65. Omega-3 polyunsaturated fatty acids and corneal nerve health: Current evidence and future directions10.1016/j.jtos.2022.10.006 ↗
66. Sarkar, T., Smaoui, S., and Petkoska, A.T. (2025). Chapter 18—Functional foods for ocular health and vision. Unleashing the Power of Functional Foods and Novel Bioactives, Academic Press.
67. Centennial Review: Effects of vitamins A, D, E, and C on the chicken immune system10.1016/j.psj.2020.12.027 ↗
68. Holban, A.M., and Grumezescu, A.M. (2018). Chapter 8—Beta Glucan as Therapeutic Food. Therapeutic Foods, Academic Press.
69. Krishna Banik, B., and Das, A. (2024). Chapter 9—Anticancer drugs from hormones and vitamins. Natural Products as Anticancer Agents, Elsevier.10.1016/B978-0-323-99710-2.00006-8 ↗
70. The Effect of Zinc Supplementation on Endocrine Parameters and Hormonal Profiles in Women Diagnosed with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis10.1016/j.cdnut.2024.103758 ↗
71. Novel promising boron agents for boron neutron capture therapy: Current status and outlook on the future10.1016/j.ccr.2024.215795 ↗
72. Liu, Y., Pang, D., Xing, D., Wang, W., Li, Q., Liao, S., Li, E., and Zou, Y. (2023). Cinnamon free phenolic extract regulates glucose absorption in intestinal cells by inhibiting glucose transporters. Food Biosci., 52.10.1016/j.fbio.2023.102405 ↗
73. The Alpha-Lipoic Acid Improves Glucose Metabolism and Hyperinsulinemia in Acute Intermittent Porphyria: A Nutritional Concept for the Management of Rare Disorders10.1016/j.jcmgh.2023.11.007 ↗
74. Kour, J., and Nayik, G.A. (2022). Chapter 21—Berberine. Nutraceuticals and Health Care, Academic Press.
75. Titanium dioxide-induced fibrotic liver model and the therapeutic effect of resveratrol by modulation of α-SMA and 8-oHdG expressions, oxidative stress, and inflammation10.1016/j.tice.2025.102748 ↗
76. Pandey, K.B., and Suttajit, M. (2023). Chapter 13—Tea catechins as potent antioxidant and anti-inflammatory agents: Possibilities of drug development to promote healthy aging. Plant Bioactives as Natural Panacea Against Age-Induced Diseases, Elsevier.
77. Gao, H., Seidi, F., Cai, Y., Sun, Z., Bian, H., Dai, H., and Xu, T. (2025). Construction of curcumin-conjugated pH-responsive lignin-based nanoparticles for alleviating oxidative stress: Stability, antioxidant activity and biocompatibility. Int. J. Biol. Macromol., 302.10.1016/j.ijbiomac.2025.140036 ↗
78. Yamamoto, A., Sly, P.D., Khachatryan, L., Begum, N., Yeo, A.J., Robinson, P.D., Cormier, S.A., and Fantino, E. (2025). Astaxanthin protects against environmentally persistent free radical-induced oxidative stress in well-differentiated respiratory epithelium. Redox Biol., 81.10.1016/j.redox.2025.103542 ↗
79. Protective effects of alpha lipoic acid (ALA) are mediated by hormetic mechanisms10.1016/j.fct.2023.113805 ↗
80. Protective effect of S-nitroso-acetilcysteine (SNAC) in experimental liver steatosis induced by choline deficient diet10.1016/S0016-5085(03)83827-1 ↗
81. Cultivation of Vitamin C-Rich Vegetables for Space-Radiation Mitigation10.3390/radiation4010008 ↗
82. Ghosh, D. (2021). Chapter 12—Efficacy of dietary polyphenols for neuroprotective effects and cognitive improvements. Nutraceuticals in Brain Health and Beyond, Academic Press.
83. Omega-3 polyunsaturated fatty acids attenuate cognitive impairment via the gut-brain axis in diabetes-associated cognitive dysfunction rats10.1016/j.bbi.2025.03.015 ↗
84. Soy flavonoids prevent cognitive deficits induced by intra-gastrointestinal administration of beta-amyloid10.1016/j.fct.2020.111396 ↗
85. Krittanawong, C. (2025). Chapter 3—Spaceflight precision nutrition. Precision Medicine for Long and Safe Permanence of Humans in Space, Academic Press.
86. Spirulina platensis components mitigate bone density loss induced by simulated microgravity: A mechanistic insight10.1016/j.foodchem.2024.141361 ↗
87. The care and feeding of spacemen
88. Unveiling the nutritional and antioxidant properties of brown algae resources (Dictyota J.V. Lamouroux) from the Bay of Bengal and Arabian Sea, Indian coast10.1016/j.heliyon.2024.e40693 ↗
89. Untapping the potential of algae for β-glucan production: A review of biological properties, strategies for enhanced production and future perspectives10.1016/j.carbpol.2024.122895 ↗
90. Omega-3 fatty acid and B12 vitamin content in Baltic algae10.1016/j.algal.2022.102860 ↗
91. Varjani, S., Pandey, A., Bhaskar, T., Mohan, S.V., and Tsang, D.C.W. (2022). Chapter 20—Algae as sustainable food in space missions. Biomass, Biofuels, Biochemicals, Elsevier.
92. Melton, L., Shahidi, F., and Varelis, P. (2019). The Spaceflight Food System: A Case Study in Long Duration Preservation. Encyclopedia of Food Chemistry, Academic Press.
93. Sun, D.-W. (2014). Chapter 1—High-Pressure Processing of Foods: An Overview. Emerging Technologies for Food Processing, Academic Press. [2nd ed.].
94. Advanced retorting, microwave assisted thermal sterilization (MATS), and pressure assisted thermal sterilization (PATS) to process meat products10.1016/j.meatsci.2014.06.027 ↗
95. Douglas, G.L., Cooper, M.R., Bermudez-Aguirre, D., and Sirmons, T. (2016). Risk of Performance Decrement and Crew Illness Due to an Inadequate Food System, NTRS-NASA Technical Reports Server.
96. 3D Printing Applications for Space Missions10.3357/AMHP.4633.2016 ↗
97. 3D printing for space food applications: Advancements, challenges, and prospects
98. Effect of post-processing treatments on the quality of three-dimensional printed rice starch constructs10.1111/jfpe.13772 ↗
99. An exploratory consumer study of 3D printed food perception in a real-life military setting10.1016/j.foodqual.2020.104001 ↗