Smart Poly(acrylic acid)/Poly(acrylamide) Microgels with Interpenetrating Polymer Network Structure
Source abstract
Abstract
Microgels with precisely tuned properties are of great importance as drug delivery systems. Here, we report the synthesis of microgel particles (MGs) with an interpenetrating polymer network structure composed of poly(acrylic acid) (PAA) and polyacrylamide (PAAM) for their potential application as cationic drug carriers. The MG properties were investigated via several analytical techniques, such as Dynamic Light Scattering (DLS) and zeta potential (ZP) measurements, Diffusion Nuclear Magnetic Resonance (NMR) spectroscopy, Asymmetrical Flow Field-Flow Fractionation (AF4) and Transmission Electron Microscopy (TEM). The MGs show pH-dependent swelling behavior with a radius of ~100 nm at collapsed state (pH < 4.5) and swell up to ~450 nm (pH~7), while their ZP decreases from −5 to −40 mV, depending on their composition. The results of the conducted studies demonstrate the potential of synthesized microgels for drug delivery in the gastrointestinal tract.
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Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Polymer Synthesis and Characterization · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory on Structure and Properties of Polymers, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J. Bourchier Blvd., 1164 Sofia, Bulgaria
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 9, 1113 Sofia, Bulgaria
Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Strasse 6, 01109 Dresden, Germany
Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa
Funding
DAAD
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