The Influence of Propolis Nonwoven Scaffolds on Burn Wound’s Heparan Sulfates and Hyaluronan
Source abstract
Abstract
Innovative types of dressings should manifest biodegradability and non-immunogenicity and prevent dehydration. The mentioned technological features are demonstrated by polymeric, nonwoven propolis dressings, which exhibit regenerative properties, produced with the implementation of the electrospinning method. These features are highly needed in the course of burn wound healing. To analyze the dynamics of the changes in content of glycosaminoglycans (GAGs), such as heparan sulfates and hyaluronan, a well-known protocol of burn wound healing (the Hoekstra model) was used. Burn wounds were subsequently treated with nonwoven dressings containing either 5% wt or 10% wt propolis. Control groups were treated with either a saline salt solution or nonwoven dressings without propolis. Statistical differences between groups were determined by a multivariate analysis of variance (ANOVA) and Tukey’s post hoc tests. Evaluation of the effectiveness of nonwoven dressings containing 5% wt and 10% wt propolis in healing burn wounds, based on the dynamics and concentration of GAGs, revealed apitherapeutic positive effects on injured tissue healing. This research underscores the advantageous impact of utilizing nonwoven dressings containing propolis for the treatment of burn wounds.
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Research context
OpenAlex topics: Bee Products Chemical Analysis · Tendon Structure and Treatment · Body Contouring and Surgery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 10 Jedności, 41-200 Sosnowiec, Poland
Student Research Club at the Department of Community Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 10 Jedności, 41-200 Sosnowiec, Poland
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 M. Curie-Skłodowskiej, 41-819 Zabrze, Poland
Department of Biopharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 8 Jedności, 41-200 Sosnowiec, Poland
Department of Chemistry of Natural Products, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland
Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University of Varna, 84B Tzar Osvoboditel Blvd., 9002 Varna, Bulgaria
Faculty of Science and Technology, Institute of Biomedical Engineering, University of Silesia in Katowice, 39 Będzińska, 41-200 Sosnowiec, Poland
Department of Clinical Chemistry and Laboratory Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 8 Jedności, 41-200 Sosnowiec, Poland
Department of Toxicology and Bioanalysis, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 30 Ostrogórska, 41-200 Sosnowiec, Poland
Funding
European Union-Next Generation EU
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