Mesoporous Bioactive Glass Nanolayer‐Modified Zirconia Coatings on Ti‐6Al‐4V with Improved In Vitro Bioactivity

The bioactivity of coatings on alloy implants plays critical roles in the fast osteointegration and maintenance of a long‐term life span of the implants. The aim of this study is to incorporate nanopores and bioactive components into the plasma‐sprayed coatings by constructing nanopores and bioactive elements on the surface of coatings and further improve their in vitro bone‐forming activity. In this study, mesoporous bioactive glasses ( MBG ) were used for modifying the surface of ZrO ₂ coatings on Ti‐6Al‐4V by spin‐coating methods. The result shows that MBG nanolayer has been successfully coated on the surface of ZrO ₂ coatings. The MBG ‐modified ZrO ₂ coatings have improved apatite‐mineralization ability and stable bonding strength. In addition, the attachment, proliferation, alkaline phosphate activity, and bone‐related gene expression of rabbit bone marrow stromal cells on MBG ‐ZrO ₂ coating were also enhanced as compared with conventional bioactive glass‐modified ZrO ₂ coatings and pure ZrO ₂ coatings. The results indicated that MBG ‐modified ZrO ₂ coatings on Ti alloy are promising for orthopedic application.