Simulation Study on the Effects of Environment and Structure on Bone Tissue Scaffold Flow Properties
Source abstract
Abstract
One of the hottest topics in current research is the creation of scaffolds for bone tissue restoration that are both biocompatible and tissue inducible. The aim of this work is to develop a numerical model to study the effects of temperature, velocity, and scaffold structure on flow and biomechanical properties, as well as to optimize design parameters to improve tissue engineering outcomes. The results show that the fluid transport properties of cylindrical unit cell architectures are superior. For effective mass transfer, pore diameters > 4 mm and porosity > 60% are ideal design parameters. With important clinical and financial implications, these discoveries offer theoretical direction and economical methods for developing bone tissue engineering.
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Research context
OpenAlex topics: Orthopaedic implants and arthroplasty · Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Mechanical and Automotive Engineering, Shanghai University of Engineering Science, Shanghai 201620, China
Funding
National Natural Science Foundation of China · Project of Shanghai Municipal Science and Technology Commission
References (38)
Show source-provided references
1. Review on Engineering of Bone Scaffolds Using Conventional and Additive Manufacturing Technologies10.1089/3dp.2022.0360 ↗
2. A review of bioceramic porous scaffolds for hard tissue applications: Effects of structural features10.1016/j.ceramint.2020.03.192 ↗
3. Liu, J., Yang, L.L., Liu, K.X., and Gao, F. (2023). Hydrogel scaffolds in bone regeneration: Their promising roles in angiogenesis. Front. Pharmacol., 14.10.3389/fphar.2023.1050954 ↗
4. Comparative review of piezoelectric biomaterials approach for bone tissue engineering10.1080/09205063.2022.2065409 ↗
5. Lu, Y., Wang, X.G., Chen, H., Li, X., Liu, H., Wang, J.C., and Qian, Z.H. (2024). “Metal-bone” scaffold for accelerated peri-implant endosseous healing. Front. Bioeng. Biotechnol., 11.10.3389/fbioe.2023.1334072 ↗
6. Bone tissue engineering: A review in bone biomimetics and drug delivery strategies10.1002/btpr.246 ↗
7. Autologous bone graft: Is it still the gold standard?10.1016/j.injury.2021.01.043 ↗
8. Zenebe, C.G. (2022). A Review on the Role of Wollastonite Biomaterial in Bone Tissue Engineering. Biomed. Res. Int., 2022.10.1155/2022/4996530 ↗
9. Anandhapadman, A., Venkateswaran, A., Jayaraman, H., and Ghone, N.V. (2022). Advances in 3D printing of composite scaffolds for the repairment of bone tissue associated defects. Biotechnol. Progr., 38.10.1002/btpr.3234 ↗
10. Macías, I., Alcorta-Sevillano, N., Infante, A., and Rodríguez, C. (2021). Cutting Edge Endogenous Promoting and Exogenous Driven Strategies for Bone Regeneration. Int. J. Mol. Sci., 22.10.3390/ijms22147724 ↗
11. Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds
12. Additive Manufacturing of Bio-Inspired Microstructures for Bone Tissue Engineering10.1007/s40799-023-00630-8 ↗
13. Bone Tissue Engineering10.1007/s40610-015-0022-2 ↗
14. Bioceramics: A review on design concepts toward tailor-made (multi)-functional materials for tissue engineering applications10.1007/s10853-023-08226-8 ↗
15. Tissue-engineered bones with adipose-derived stem cells-composite polymer for repair of bone defects10.2217/rme-2022-0044 ↗
16. Bone Tissue Engineering Scaffolds: Materials and Methods10.1089/3dp.2022.0216 ↗
17. Influence of Thermal Processing Conditions on Mechanical and Material Properties of 3D Printed Thin-Structures Using PEEK Material10.1007/s12541-022-00650-1 ↗
18. Advances in additive manufacturing for bone tissue engineering scaffolds10.1016/j.msec.2019.03.037 ↗
19. How Does Scaffold Porosity Conduct Bone Tissue Regeneration?10.1002/adem.202100463 ↗
20. Mukasheva, F., Adilova, L., Dyussenbinov, A., Yernaimanova, B., Abilev, M., and Akilbekova, D. (2024). Optimizing scaffold pore size for tissue engineering: Insights across various tissue types. Front. Bioeng. Biotechnol., 12.10.3389/fbioe.2024.1444986 ↗
21. Three-dimensional plotted scaffolds with controlled pore size gradients: Effect of scaffold geometry on mechanical performance and cell seeding efficiency10.1016/j.actbio.2010.11.003 ↗
22. Porous scaffolds for bone regeneration10.1016/j.jsamd.2020.01.007 ↗
23. Permeability analysis of scaffolds for bone tissue engineering10.1016/j.jbiomech.2012.01.019 ↗
24. Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing10.1016/j.actbio.2010.06.012 ↗
25. Finite element study of scaffold architecture design and culture conditions for tissue engineering10.1016/j.biomaterials.2009.07.041 ↗
26. Polylactic acid scaffold with directional porous structure for large-segment bone repair10.1016/j.ijbiomac.2022.07.207 ↗
27. Shaping scaffold structures in rapid manufacturing implants: A modeling approach toward mechano-biologically optimized configurations for large bone defect10.1002/jbm.b.32740 ↗
28. 3D FEM model to simulate Brownian motion inside trabecular tissue from human femoral head10.1080/21681163.2021.1956370 ↗
29. Hydromechanical mechanism behind the effect of pore size of porous titanium scaffolds on osteoblast response and bone ingrowth10.1016/j.matdes.2019.108151 ↗
30. Predicting permeability of regular tissue engineering scaffolds: Scaling analysis of pore architecture, scaffold length, and fluid flow rate effects10.1080/10255842.2016.1215436 ↗
31. Gabrieli, R., Schiavi, A., and Baino, F. (2024). Determining the Permeability of Porous Bioceramic Scaffolds: Significance, Overview of Current Methods and Challenges Ahead. Materials, 17.10.3390/ma17225522 ↗
32. Pires, T.H.V., Dunlop, J.W.C., Castro, A.P.G., and Fernandes, P.R. (2022). Wall Shear Stress Analysis and Optimization in Tissue Engineering TPMS Scaffolds. Materials, 15.10.3390/ma15207375 ↗
33. Modeling fluid flow through irregular scaffolds for perfusion bioreactors10.1002/bit.22277 ↗
34. Rita, V.J., Colin, B.D., Ralph, M., and Sandra, H. (2017). Flow velocity-driven differentiation of human mesenchymal stromal cells in silk fibroin scaffolds: A combined experimental and computational approach. PLoS One, 12.10.1371/journal.pone.0180781 ↗
35. Fluid permeabilities of triply periodic minimal surfaces10.1103/PhysRevE.72.056319 ↗
36. The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth10.1016/j.biomaterials.2008.10.056 ↗
37. Investigation of Physico-mechanical Behavior, Permeability and Wall Shear Stress of Porous HA/PMMA Composite Bone Scaffold10.1007/s13369-020-04467-w ↗
38. Permeability and fluid flow-induced wall shear stress in bone scaffolds with TPMS and lattice architectures: A CFD analysis10.1016/j.euromechflu.2019.09.015 ↗