The Antioxidant Potential of Ficus Umbellata Vahl (Moraceae) That Accelerates In Vitro and the In Vivo Anti-Inflammatory Protective Effects
Source abstract
Abstract
Ficus umbellata Vahl (Moraceae), is a plant with health benefits involved in the management of menopause physiological disorders and cancers. This study aimed at investigating the antioxidant and anti-inflammatory activities of aqueous (FUAq) and methanolic (FUMeOH) extracts of Ficus umbellata. Their antioxidant activities were assayed by free radical scavenging using DPPH and ABTS assays, total antioxidant capacity, and ferrous reducing power (FRAP). Further, the effects of FUAq and FUMeOH on murine erythrocyte membrane hemolysis and protein denaturation were investigated. The in vivo anti-inflammatory activity was determined in Wistar rats with carrageenan-induced paw oedema. At tested concentrations, FUAq and FUMeOH demonstrated strong radical scavenging that was dose- and time-dependent, as well as total antioxidant capacity and ferrous ions reducing power. Moreover, they were able to stabilize murine red blood cell membranes against heat induced hemolysis and inhibit the denaturation of egg albumin at concentrations ranging from 0.125–2 mg/mL. Ficus umbellata methanolic extract at doses of 50 and 200 mg/kg endow antiedematous properties with edema inhibition percentages of 71.16 ± 1.72% and 72.98 ± 7.51%, respectively. Our findings shed light on the antioxidant and anti-inflammatory properties of Ficus umbellata that could be used in novel and safe strategies to overwhelm oxidative and inflammatory related diseases.
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Research context
OpenAlex topics: Phytochemistry and biological activities of Ficus species · Saffron Plant Research Studies · Ginger and Zingiberaceae research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biochemistry, Faculty of Science, University of Yaoundé 1, Yaoundé P.O. Box 812, Cameroon
Department of Chemistry, Physics and Environment, University Dunarea de Jos of Galati, 800008 Galați, Romania
Department of Medical and Biomedical Engineering, University of Yaoundé 1, Ebolowa P.O. Box 55, Cameroon
Laboratory of Phytoprotection and Valorization of Genetic Resources, Biotechnology Centre-Nkolbisson, University of Yaoundé 1, Yaoundé P.O. Box 812, Cameroon
Department of Animal Physiology, University of Yaoundé 1, Yaoundé P.O. Box 812, Cameroon
Funding
AGENCE UNIVERSITAIRE DE LA FRANCOPHONIE · INTERNATIONAL FOUNDATION FOR SCIENCES
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