journal article·2022-04-08Open access

Synchrotron X-ray Radiation (SXR) in Medical Imaging: Current Status and Future Prospects

Mahbubunnabi Tamal, Murad Althobaiti, Abdul-Hakeem Alomari, Sumaiya Tabassum Dipty, Khadiza Tun Suha, Maryam Al-Hashim

Applied Sciences· Volume 12· Issue 8

Abstract

Synchrotron X-ray radiation (SXR) has been widely studied to explore the structure of matter. Recently, there has been an intense focus on the medical application of SXR in imaging. This review is intended to explore the latest applications of SXR in medical imaging and to shed light on the advantages and drawbacks of this modality. The article highlights the latest developments in other fields that can greatly enhance the capability and applicability of SXR. The potentials of using machine and deep learning (DL)-based methods to generate synthetic images to use in regular clinics along with the use of photon counting X-ray detectors for spectral medical imaging with SXR are also discussed.
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Research context

OpenAlex topics: Advanced X-ray and CT Imaging · Medical Imaging Techniques and Applications · Radiomics and Machine Learning in Medical Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering, College of Engineering, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

Tamal Research Group, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

Medical Physics Section, Medical Imaging Department, King Fahad Specialist Hospital Dammam, Dammam 32252, Saudi Arabia

Funding

Ministry of Education, Saudi Arabia

References (60)

Show source-provided references
1. Mobilio, S., Federico, B.F., and Meneghini, C. (2015). Synchrotron Radiation, Springer.10.1007/978-3-642-55315-8 ↗
2. Ando, M., and Uyama, C. (1998). Medical Applications of Synchrotron Radiation, Springer.10.1007/978-4-431-68485-5 ↗
3. Functional lung imaging with synchrotron radiation: Methods and preclinical applications
4. Synchrotron radiation imaging for advancing our understanding of cardiovascular function10.1161/CIRCRESAHA.111.300096 ↗
5. Medical applications of synchrotron radiation10.1016/0168-9002(92)90569-P ↗
6. Synchrotron radiation facilities10.1038/1307 ↗
7. Nalin, G. (2021, November 06). Synchrotron Radiation and Synchrotron Light Sources. Available online: https://www.nottingham.ac.uk/aspire-itn/aspire-blog/aspire-blogs-2020/synchrotron-radiation-and-synchrotron-light-sources.aspx.
8. Synchrotron radiation in radiology: Novel X-ray sources10.1007/s00330-003-2073-7 ↗
9. Medical applications of synchrotron radiation10.1088/0031-9155/48/13/201 ↗
10. High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain10.1038/s41598-018-30501-x ↗
11. Ultrastructural Analysis of Human Gallstones using Synchrotron Radiation microCT10.2174/1386207322666190222122007 ↗
12. Synchrotron-radiation phase-contrast imaging of human stomach and gastric cancer: In vitro studies10.1107/S090904951200310X ↗
13. Synchrotron nanoscopy imaging study of scalp hair in breast cancer patients and healthy individuals: Difference in medulla loss and cortical membrane enhancements10.1002/jemt.22601 ↗
14. High-resolution imaging of the human incudostapedial joint using synchrotron-radiation phase-contrast imaging10.1111/jmi.12864 ↗
15. Quantitative and qualitative bone imaging: A review of synchrotron radiation microtomography analysis in bone research10.1016/j.jmbbm.2020.103887 ↗
16. Three Dimensional Visualization of Human Cardiac Conduction Tissue in Whole Heart Specimens by High-Resolution Phase-Contrast CT Imaging Using Synchrotron Radiation10.1177/2150135116675844 ↗
17. Detection and imaging of gadolinium accumulation in human bone tissue by micro- and submicro-XRF10.1038/s41598-020-63325-9 ↗
18. Synchrotron soft X-ray imaging and fluorescence microscopy reveal novel features of asbestos body morphology and composition in human lung tissues10.1186/1743-8977-8-7 ↗
19. Biomolecular investigation of human substantia nigra in Parkinson’s disease by synchrotron radiation Fourier transform infrared microspectroscopy10.1016/j.abb.2006.12.027 ↗
20. Synchrotron MicroCT Reveals the Potential of the Dual Contrast Technique for Quantitative Assessment of Human Articular Cartilage Composition10.1002/jor.24479 ↗
21. Synchrotron Radiation in Biology and Medicine10.12693/APhysPolA.141.3 ↗
22. Quantitative Imaging of Regional Aerosol Deposition, Lung Ventilation and Morphology by Synchrotron Radiation CT10.1038/s41598-018-20986-x ↗
23. Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography10.1107/S1600577518010172 ↗
24. Peleg Walg, Y., Krutman, Y., Berman, A., and Orion, I. (2021). Synchrotron X-ray Irradiation of a Rat’s Head Model: Monte Carlo Study of Chromatic Gel Dosimetry. Appl. Sci., 11.10.3390/app11167389 ↗
25. Permeability of Brain Tumor Vessels Induced by Uniform or Spatially Microfractionated Synchrotron Radiation Therapies10.1016/j.ijrobp.2017.03.025 ↗
26. Dose and diagnostic performance comparison between phase-contrast mammography with synchrotron radiation and digital mammography: A clinical study report10.1117/1.JMI.5.1.013503 ↗
27. Monochromatic breast computed tomography with synchrotron radiation: Phase-contrast and phase-retrieved image comparison and full-volume reconstruction
28. Laser-wakefield accelerators as hard x-ray sources for 3D medical imaging of human bone10.1038/srep13244 ↗
29. In-line phase-contrast breast tomosynthesis: A phantom feasibility study at a synchrotron radiation facility10.1088/0031-9155/61/16/6243 ↗
30. Kawata, Y., Niki, N., Umetani, K., Nakano, Y., Ohamatsu, H., Moriyama, N., and Itoh, H. (2013). Stochastic Tracking of Small Pulmonary Vessels in Human Lung Alveolar Walls Using Synchrotron Radiation Micro CT Images, SPIE.10.1117/12.2006895 ↗
31. Society, T.A.C. (2021, November 08). Cancer Facts and Statistics. Available online: https://www.cancer.org/research/cancer-facts-statistics.
32. Ultrasound-Guided Diffuse Optical Tomography for Predicting and Monitoring Neoadjuvant Chemotherapy of Breast Cancers: Recent Progress10.1177/0161734615580280 ↗
33. Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography10.1073/pnas.0509636103 ↗
34. Diffuse optical tomography reconstruction method using ultrasound images as prior for regularization matrix10.1117/1.JBO.22.2.026002 ↗
35. Combined optical and X-ray tomosynthesis breast imaging10.1148/radiol.10082176 ↗
36. The Molecular Architecture for the Intermediate Filaments of Hard alpha-Keratin based on the Superlattice Data Obtained from a Study of Mammals Using Synchrotron Fibre Diffraction10.1155/2011/198325 ↗
37. Identification of breast cancer-associated lipids in scalp hair10.4137/BCBCR.S9607 ↗
38. Medulla loss of scalp hair in breast cancer patients determined by near-infrared microscopy
39. Transvenous coronary angiography in humans using synchrotron radiation10.1073/pnas.83.24.9724 ↗
40. Investigating the Mechanical Characteristics of Bone-Metal Implant Interface Using in situ Synchrotron Tomographic Imaging10.3389/fbioe.2018.00208 ↗
41. Fracture mechanics by three-dimensional crack-tip synchrotron X-ray microscopy
42. Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography10.1038/s41592-021-01317-x ↗
43. MicroCT with energy-resolved photon-counting detectors10.1088/0031-9155/56/9/011 ↗
44. Vision 20/20: Single photon counting x-ray detectors in medical imaging10.1118/1.4820371 ↗
45. Photon-counting Detector CT: System Design and Clinical Applications of an Emerging Technology10.1148/rg.2019180115 ↗
46. Photon Counting Energy Dispersive Detector Arrays for X-ray Imaging10.1109/TNS.2009.2013709 ↗
47. Energy-resolved computed tomography: First experimental results10.1088/0031-9155/53/20/002 ↗
48. Hameed, K., Zainon, R., and Tamal, M. (November, January 26). Characterization of CdZnTe detector for spectral Computed Tomography. Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), Manchester, UK.
49. Performance of a Medipix3RX spectroscopic pixel detector with a high resistivity gallium arsenide sensor10.1109/TMI.2014.2317314 ↗
50. Preliminary evaluation of a silicon strip detector for photon-counting spectral CT10.1016/j.nima.2012.02.034 ↗
51. Noise Properties of Four Strategies for Incorporation of Scatter and Attenuation Information in PET Reconstruction Using the EM-ML Algorithm10.1109/TNS.2006.880973 ↗
52. High accuracy multiple scatter modelling for 3D whole body PET10.1088/0031-9155/52/3/021 ↗
53. Deformable image registration in radiation therapy10.3857/roj.2017.00325 ↗
54. Deformable image registration in radiation therapy10.1002/jmrs.446 ↗
55. Rigid and Deformable Image Registration for Radiation Therapy: A Self-Study Evaluation Guide for NRG Oncology Clinical Trial Participation10.1016/j.prro.2021.02.007 ↗
56. Use of deformable image registration techniques to estimate dose to organs at risk following prostate external beam radiation therapy and high-dose-rate brachytherapy10.5114/jcb.2021.103589 ↗
57. Comparison of different deep learning architectures for synthetic CT generation from MR images
58. Synthesized 7T MRI from 3T MRI via deep learning in spatial and wavelet domains10.1016/j.media.2020.101663 ↗
59. Magnetic resonance image (MRI) synthesis from brain computed tomography (CT) images based on deep learning methods for magnetic resonance (MR)-guided radiotherapy10.21037/qims-19-885 ↗
60. Li, Y., Li, W., He, P., Xiong, J., Xia, J., and Xie, Y. (2019, January 22–24). CT synthesis from MRI images based on deep learning methods for MRI-only radiotherapy. Proceedings of the 2019 International Conference on Medical Imaging Physics and Engineering (ICMIPE), Shenzhen, China.10.1109/ICMIPE47306.2019.9098190 ↗