Eudragit E100/Hesperidin 3D Printing Filaments: Preparation, Characterization, and In Vitro Release Studies
Source abstract
Abstract
The importance of the Eudragit® E100 copolymer (E100) is recognized in the pharmaceutical industry as a pH-dependent coating material in conventional oral administration dosage applications, where a modified release profile is required. On the other hand, its arrangement for 3D printing of cylindrical-shaped filaments containing drugs (to produce customized pharmaceuticals), is still scarce in the literature, and is currently an open field of research. One of the main challenges involves the manufacture of filaments that are flexible and functional, as their cylindrical shape (which is necessary for its use on FDM 3D printers) significantly increases the material’s fragility. Thus, the objective of this work was to prepare and characterize E100/Hesperidin (Hsp) filaments, and to study in vitro dissolution from Hsp active molecules of this unconventional polymeric matrix. The hybrid filaments were produced using a surface chemical treatment of the material resulting from a hot-melt extrusion process. The microstructural characterization of the filaments was performed using SEM, XRD, FTIR and ATR. The thermal analysis of the materials was performed using DSC, and the mechanical resistance was analyzed using flexural testing. The in vitro release profiles of the filament-arranged drug were evaluated in solutions of simulated gastro and intestinal fluids.
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Research context
OpenAlex topics: 3D Printing in Biomedical Research · Additive Manufacturing and 3D Printing Technologies · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Research Group on Electrospinning and Nanotechnology Applications (GPEA-Nano), Department of Materials Science, Federal University of São Francisco Valley, Juazeiro 48902-300, Brazil
Laboratory of Phycology, Department of Botany, Federal University of Santa Catarina, Florianópolis 88040-535, Brazil
Formulation & Application Services—Health Care Department, Evonik Brasil Ltd., São Paulo 04711-904, Brazil
Research and Extension Center, Laboratory of Fuels and Materials (NPE/LACOM), Department of Chemistry, Federal University of Paraíba, Campus I, João Pessoa 58051-900, Brazil
Electrical and Computer Engineering Department—CEMMPRE, FCTUC, Polo 2, University of Coimbra, 3030-290 Coimbra, Portugal
Funding
Fundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco · Fundação para a Ciência e a Tecnologia
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