Anti-Inflammatory Butenolides from a Marine-Derived Streptomyces sp. 13G036
Source abstract
Abstract
Butenolides are a family of lactones containing a double bond and have been frequently found in the extracts of Streptomyces bacterial species with various pharmacological activities. In this study, seven butenolides (1–7) were discovered and isolated from the culture broth of a marine-derived Streptomyces sp. 13G036 based on a molecular networking analysis. Among the seven isolates, compound 7 was first isolated as a natural product in this study. The structures of compounds 1–7 were determined by combined analysis of 1D/2D Nuclear Magnetic Resonance (NMR) spectra, Mass Spectrometry (MS) spectra and electronic circular dichroism (ECD) data. Compounds 1–6 showed potential anti-inflammatory activities by inhibiting the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6) in lipopolysaccharide-stimulated macrophages.
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Research context
OpenAlex topics: Microbial Natural Products and Biosynthesis · Marine Sponges and Natural Products · Natural product bioactivities and synthesis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550025, China
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (KMEDIhub), Daegu 41061, Korea
Preclinical Research Center, KMEDIhub, Daegu 41061, Korea
Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Korea
College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21plus KNU Multi-Omics Based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Korea
Funding
the 2020 Yeungnam University Research Grants, and the research grants from the Basic Science Research Program through the National Research Foundation of Korea (NRF)
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