Effect of Allium fistulosum Extracts on the Stimulation of Longitudinal Bone Growth in Animal Modeling Diet-Induced Calcium and Vitamin D Deficiencies
Source abstract
Abstract
Allium fistulosum is a perennial plant species grown worldwide belonging to the family Liliaceae. In Korean medicine, it is referred to as Chongbaek (CB), and it is prescribed for symptoms associated with the common cold due to its antipyretic properties. This study examined the effects of aqueous (CBW) and 30% ethanol (CBE) extracts on bone growth using a calcium- and vitamin D-deficient animal model. In an in vitro experiment, the alkaline phosphate activities of the extracts were examined using MC3T3-E1 and MG63 cells, and both the aqueous and ethanolic extracts had significant alkaline phosphate activities. In vivo, a serum analysis indicated that the CB extracts promoted bone growth based on the osteogenic markers ALP, calcium, osteocalcin, and collagen type 1 and increased the bone mineral content (BMC), bone mineral density (BMD), and growth plate length. Overall, our results indicate that both CBW and CBE of A. fistulosum can be utilized to facilitate bone growth and increase BMD in children and adolescents by lengthening the growth plate without adverse side effects, such as metabolic disorders or the release of obesity-inducing hormones.
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Research context
OpenAlex topics: Garlic and Onion Studies · Inflammatory Bowel Disease · Therapeutic Uses of Natural Elements
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
KM Convergence Research Division, Korea Institute of Oriental Medicine, Yuseongdae-ro, Daejeon 34054, Korea
NongHyup Agribusiness Group Inc., The Korea Genseng Inspection Office, 52 Geumsan-up, Banadong-gil, Geumsan-gun, Chungcheongnam-do 32748, Korea
Funding
National Research Council of Science & Technology (NST)
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