Antibacterial Behavior of Chitosan-Sodium Hyaluronate-PEGDE Crosslinked Films
Source abstract
Abstract
Chitosan is a natural polymer that can sustain not only osteoblast adhesion and proliferation for bone regeneration purposes, but it is also claimed to exhibit antibacterial properties towards several Gram-positive and Gram-negative bacteria. In this study, chitosan was modified with sodium hyaluronate, crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and both osteoblast cytotoxicity and antibacterial behavior studied. The presence of sodium hyaluronate and PEGDE on chitosan was detected by FTIR, XRD, and XPS. Chitosan (CHT) films with sodium hyaluronate crosslinked with PEGDE showed a better thermal stability than pristine hyaluronate. In addition, osteoblast cytocompatibility improved in films containing sodium hyaluronate. However, none of the films exhibit antimicrobial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus while exhibiting low to mild activity against Salmonella typhimurion.
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Research context
OpenAlex topics: Nanocomposite Films for Food Packaging · Polymer Surface Interaction Studies · Antimicrobial agents and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Facultad de Odontología, Universidad Autónoma de Yucatán, Calle 61 A #492 A x 90 y Av. Itzáes, Centro., Mérida C.P. 97000, Mexico
Unidad de Materiales, Centro de Investigación Científica de Yucatán, Calle 43 No. 130 x 32 y 34, Colonia Chuburná de Hidalgo, Mérida C.P. 97205, Mexico
Laboratorio de Ciencias Básicas, Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, Ave. Dr. Manuel Nava No. 2, Zona Universitaria, San Luis C.P. 78290, Mexico
Laboratorio de Microbiología, Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, Ave. Dr. Manuel Nava No. 2, Zona Universitaria, San Luis C.P. 78290, Mexico
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C. Parque Científico Tecnológico de Yucatán, km 5.5 Carretera, Sierra Papacal-Chuburná, Chuburná C.P. 97302, Mexico
Instituto de Ciencia y Tecnología de Polímeros, Juan de la Cierva, 3, Madrid C.P. 28006, Spain
Funding
Consejo Nacional de Ciencia y Tecnología
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