Antibiotic Potential and Chemical Composition of the Essential Oil of Piper caldense C. DC. (Piperaceae)
Source abstract
Abstract
Infections by multiresistant microorganisms have led to a continuous investigation of substances acting as modifiers of this resistance. By following this approach, the chemical composition of the essential oil from Piper caldense leaf and its antimicrobial potential were investigated. The antimicrobial activity was determined by broth microdilution method providing values for minimum inhibitory concentration (MIC), IC50, and minimum fungicidal concentration (MFC). The essential oil was tested as a modulator for several antibiotics, and its effect on the morphology of Candida albicans (CA) strains was also investigated. The chemical characterization revealed an oil composed mainly of sesquiterpenes. Among them are caryophyllene oxide (13.9%), spathulenol (9.1%), δ-cadinene (7.6%) and bicyclogermacrene (6.7%) with the highest concentrations. The essential oil showed very low activity against the strains of CA with the lowest values for IC50 and MFC of 1790 μg/mL and 8192 μg/mL, respectively. The essential oil modulated the activity of fluconazole against CA URM 4387 strain, which was demonstrated by the lower IC50 obtained, 2.7 μg/mL, whereas fluconazole itself presented an IC50 of 7.76 μg/mL. No modulating effect was observed in the MFC bioassays. The effect on fungal morphology was observed for both CA INCQS 40006 and URM 4387 strains. The hyphae projection was completely inhibited at 4096 μg/mL and 2048 μg/mL, respectively. Thus, the oil has potential as an adjuvant in antimicrobial formulations.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Essential Oils and Antimicrobial Activity · Piperaceae Chemical and Biological Studies · Traditional and Medicinal Uses of Annonaceae
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Postgraduate Program in Plant Biology, Federal University of Pernambuco—UFPE, Recife 50670-901, PE, Brazil
Laboratory of Applied Mycology of Cariri, Regional University of Cariri—URCA, Crato 63105-000, CE, Brazil
Research Laboratory of Natural Products, Federal University of Paraná—UFPR, Matinhos 83260-000, PR, Brazil
Department of Agricultural and Environmental Sciences, Milan State University, 20133 Milan, Italy
Department of Biomedical, Surgical and Dental Sciences, Milan State University, 20142 Milan, Italy
Laboratory of Microbiology and Molecular Biology—LMBM, Regional University of Cariri—URCA, Crato 63105-000, CE, Brazil
References (35)
Show source-provided references
1. Phytocompounds and modulatory effects of Anacardium microcarpum (cajui) on antibiotic drugs used in clinical infections
2. Chemical composition and anti-Candida potencial of the extracts of Tarenaya spinosa (Jacq.) Raf. (Cleomaceae)10.1016/j.cimid.2019.02.005 ↗
3. Evaluation of the interaction between the Poincianella pyramidalis (Tul.) LP queiroz extract and antimicrobials using biological and analytical models10.1371/journal.pone.0155532 ↗
4. Essential oil of Eucalyptus camaldulensis Dehn potentiates β-lactam activity against Staphylococcus aureus and Escherichia coli resistant strains10.1016/j.indcrop.2017.10.048 ↗
5. Fungi pathogenic to humans: molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus
6. Psidium guajava L. and Psidium brownianum Mart ex DC.: Chemical composition and anti–Candida effect in association with fluconazole10.1016/j.micpath.2016.04.013 ↗
7. The distinct morphogenic states of Candida albicans10.1016/j.tim.2004.05.008 ↗
8. Are ethnopharmacological surveys useful for the discovery and development of drugs from medicinal plants?10.1016/j.bjp.2014.04.003 ↗
9. Guimarães, E.F., Carvalho-Silva, M., Monteiro, D., Medeiros, E.S., and Queiroz, G.A. (2018, June 07). Piperaceae in Lista de Espécies da Flora do Brasil, Available online: http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB12756.
10. Caldensin, a new natural n-methylaristolactam from Piper caldense10.1076/phbi.41.3.216.15091 ↗
11. Antimicrobial activity of products obtained from Piper species (Piperaceae)
12. Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis10.1023/A:1007178924408 ↗
13. Antifungal compounds from Piper species10.2174/157340711798375822 ↗
14. Ethnobotanical study of medicinal plants used by Ribeirinhos in the North Araguaia microregion, Mato Grosso, Brazil10.1016/j.jep.2017.04.023 ↗
15. Chemical composition and antifungal activity of the essential oil from Piper amalago L.
16. Antifungal activity of Piper aduncum and Peperomia pellucida leaf ethanol extract against Candida albicans
17. Antifungal and antibacterial activity of black betel (Piper betle L. var Nigra) extract
18. Estrategias en la selección de las plantas medicinales a investigar
19. Potential antimicrobial and chemical composition of essential oils from Piper caldense tissues
20. Chemical composition, antimicrobial, modulator and antioxidant activity of essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants10.1016/j.cimid.2019.04.010 ↗
21. Variation in themain componentes of the essential oils isolated from Thymbra capitata L. (Cav.) and Origanum vulgare L.10.1021/jf0510079 ↗
22. Chemical composition and toxicological evaluation of Hyptis suaveolens (L.) Poiteau (LAMIACEAE) in Drosophila melanogaster and Artemia salina10.1016/j.sajb.2017.10.003 ↗
23. Activity of phenolic compounds from plant origin against Candida species10.1016/j.indcrop.2015.05.067 ↗
24. Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options10.1099/jmm.0.045054-0 ↗
25. Silva, G.A.T.D. (2013). Estudo fitoquímico das folhas e frutos de Piper caldense C. DC. (Piperaceae), Universidade Federal da Paraíba.
26. Chemical composition, antifungal activity and potential anti-virulence evaluation of the Eugenia uniflora essential oil against Candida spp.10.1016/j.foodchem.2018.04.015 ↗
27. Phenolic composition and medicinal usage of Psidium guajava L.: Antifungal activity or inhibition of virulence?
28. Antimicrobial activity and Modulatory effect of essential oil from the leaf of Rhaphiodon echinus (Nees & Mart) Schauer on some antimicrobial drugs10.3390/molecules21060743 ↗
29. Interactions of cyclic hydrocarbons with biological membranes10.1016/S0021-9258(17)37154-5 ↗
30. Polyphenolic composition, antibacterial, modulator and neuroprotective activity of Tarenaya spinosa (Jacq.) Raf.(Cleomaceae)10.4103/2221-1691.250264 ↗
31. Adams, R.P. (2007). Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry, Allured Publishing Corporation.
32. De novo antimicrobial peptides with low mammalian cell toxicity10.1021/jm9509410 ↗
33. Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine10.1159/000151267 ↗
34. In vitro pharmacodynamic properties of MK-0991 determined by time-kill methods
35. Sidrim, J.J.C., and Rocha, M.F.G. (2010). Micologia Médica à luz de autores contemporâneos, Guanabara Koogan. [1st ed.].