A Hybrid Nanoplatform of Graphene Oxide/Nanogold for Plasmonic Sensing and Cellular Applications at the Nanobiointerface
Source abstract
Abstract
In this study, nanocomposites of spherical gold nanoparticles (AuNPs) and graphene oxide (GO) nanosheets were fabricated by a simple one-step reduction method. The characterisation by UV-visible spectroscopy of the plasmonic sensing properties pointed out to a strong interaction between graphene and metal nanoparticles in the hybrid GO-AuNP, as confirmed by nuclear magnetic resonance. Moreover, atomic force microscopy analyses demonstrated that the gold nanoparticles were mostly confined to the basal planes of the GO sheets. The response of the nanoassemblies at the biointerface with human neuroblastoma SH-SY5Y cell line was investigated in terms of nanotoxicity as well as of total and mitochondrial reactive oxygen species production. Confocal microscopy imaging of cellular internalization highlighted the promising potentialities of GO-AuNP nanoplatforms for theranostic (i.e., sensing/imaging + therapy) applications.
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Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoparticles: synthesis and applications · Carbon and Quantum Dots Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory of Hybrid NanoBioInterfaces (NHIL), Department of Chemical Sciences, University of Catania, viale Andrea Doria 6, 95125 Catania, Italy
Department of Chemical Sciences, University of Catania, viale Andrea Doria 6, 95125 Catania, Italy
Funding
Ministero dell’Istruzione, dell’Università e della Ricerca · Università di Catania
References (62)
Show source-provided references
1. Honeycomb Carbon: A Review of Graphene10.1021/cr900070d ↗
2. Graphene Based Electrochemical Sensors and Biosensors: A Review10.1002/elan.200900571 ↗
3. Graphene: Status and Prospects10.1126/science.1158877 ↗
4. The chemistry of graphene oxide10.1039/B917103G ↗
5. Nano-Carbons as Theranostics10.7150/thno.4156 ↗
6. Graphene-based platforms for cancer therapeutics10.4155/tde.15.93 ↗
7. Fabrication of Flexible Metal-Nanoparticle Films Using Graphene Oxide Sheets as Substrates10.1002/smll.200900548 ↗
8. The Route to Functional Graphene Oxide10.1002/cphc.201000132 ↗
9. Directed nanoparticle reduction on graphene10.1016/S1369-7021(12)70047-0 ↗
10. Graphene based enzymatic bioelectrodes and biofuel cells10.1039/C4NR07586B ↗
11. Saifullah, B., Buskaran, K., Shaikh, R.B., Barahuie, F., Fakurazi, S., Mohd Moklas, M.A., and Hussein, M.Z. (2018). Graphene Oxide(-)PEG(-)Protocatechuic Acid Nanocomposite Formulation with Improved Anticancer Properties. Nanomaterials (Basel), 8.10.3390/nano8100820 ↗
12. Fabrication, Mechanical Properties, and Biocompatibility of Graphene-Reinforced Chitosan Composites10.1021/bm100470q ↗
13. Covalently Bonded Chitosan on Graphene Oxide via Redox Reaction10.3390/ma6030911 ↗
14. Properties and structural characterization of oxide starch/chitosan/graphene oxide biodegradable nanocomposites10.1002/app.34901 ↗
15. In Vivo Pharmacokinetics, Long-Term Biodistribution, and Toxicology of PEGylated Graphene in Mice10.1021/nn1024303 ↗
16. Functionalization of reduced graphene oxide nanosheets via stacking interactions with the fluorescent and water-soluble perylene bisimide-containing polymers10.1016/j.polymer.2011.03.054 ↗
17. Alharbi, R., Irannejad, M., and Yavuz, M. (2017). Au-Graphene Hybrid Plasmonic Nanostructure Sensor Based on Intensity Shift. Sensors, 17.10.3390/s17010191 ↗
18. Systematic study on the sensitivity enhancement in graphene plasmonic sensors based on layer-by-layer self-assembled graphene oxide multilayers and their reduced analogues10.1021/am508103z ↗
19. Surface Modification of Graphene Nanosheets with Gold Nanoparticles: The Role of Oxygen Moieties at Graphene Surface on Gold Nucleation and Growth10.1021/cm901052s ↗
20. Stable graphene oxide–gold nanoparticle platforms for biosensing applications10.1039/C7CP04817C ↗
21. Graphene−Metal Particle Nanocomposites10.1021/jp807989b ↗
22. In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags10.1038/nbt1377 ↗
23. Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents10.1021/nl047950t ↗
24. Gold and Silver Nanoparticles for Applications in Theranostics10.2174/1568026616666160715163346 ↗
25. Recent advances in functional nanostructures as cancer photothermal therapy10.2147/IJN.S161031 ↗
26. Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains10.1021/bc049951i ↗
27. In situ sonochemical reduction and direct functionalization of graphene oxide: A robust approach with thermal and biomedical applications10.1016/j.ultsonch.2016.05.015 ↗
28. A systems toxicology approach to the surface functionality control of graphene-cell interactions10.1016/j.biomaterials.2013.09.108 ↗
29. Toxicity of graphene in normal human lung cells (BEAS-2B)10.1166/jbn.2011.1224 ↗
30. Zhang, X.F., Liu, Z.G., Shen, W., and Gurunathan, S. (2016). Silver Nanoparticles: Synthesis, Characterization, Properties, Applications, and Therapeutic Approaches. Int. J. Mol. Sci., 17.10.3390/ijms17091534 ↗
31. The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration10.1016/j.biomaterials.2013.11.020 ↗
32. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways10.1016/j.biomaterials.2011.09.091 ↗
33. Nanotoxicity of Graphene and Graphene Oxide10.1021/tx400385x ↗
34. Role of surface charge and oxidative stress in cytotoxicity and genotoxicity of graphene oxide towards human lung fibroblast cells10.1002/jat.2877 ↗
35. A study of the nucleation and growth processes in the synthesis of colloidal gold10.1039/df9511100055 ↗
36. Extinction coefficient of gold nanoparticles with different sizes and different capping ligands10.1016/j.colsurfb.2006.08.005 ↗
37. Surface tailoring of polyacrylate-grafted graphene oxide for controlled interactions at the biointerface10.1016/j.jcis.2017.07.080 ↗
38. Nano-graphene oxide for cellular imaging and drug delivery10.1007/s12274-008-8021-8 ↗
39. Cytotoxic phenanthroline derivatives alter metallostasis and redox homeostasis in neuroblastoma cells10.18632/oncotarget.26346 ↗
40. Charge Transfer at Hybrid Interfaces: Plasmonics of Aromatic Thiol-Capped Gold Nanoparticles10.1021/acsnano.5b02864 ↗
41. A unified view of propagating and localized surface plasmon resonance biosensors10.1007/s00216-004-2708-9 ↗
42. Present and future of surface plasmon resonance biosensors10.1007/s00216-003-2101-0 ↗
43. Nanoplasmonic sensing and detection10.1126/science.aaa6805 ↗
44. Preparation, characterization, and antibacterial activity of silver nanoparticle-decorated graphene oxide nanocomposite10.1021/acsami.5b00937 ↗
45. A study on the sizes and concentrations of gold nanoparticles by spectra of absorption, resonance Rayleigh scattering and resonance non-linear scattering10.1016/j.saa.2004.10.035 ↗
46. Shape-dependent surface-enhanced Raman scattering in gold-Raman probe-silica sandwiched nanoparticles for biocompatible applications10.1088/0957-4484/23/11/115501 ↗
47. Adsorption of NGF and BDNF derived peptides on gold surfaces10.1039/C3CP52499J ↗
48. Alkanethiolate Gold Cluster Molecules with Core Diameters from 1.5 to 5.2 nm: Core and Monolayer Properties as a Function of Core Size10.1021/la970588w ↗
49. NMR Diffusion, Relaxation, and Spectroscopic Studies of Water Soluble, Monolayer-Protected Gold Nanoclusters†10.1021/jp011123o ↗
50. Proton chemical shift assignments in citrate and trimethyl citrate in chiral media10.1021/ja00028a004 ↗
51. NMR Techniques for Noble Metal Nanoparticles10.1021/cm504809c ↗
52. Effect of graphene oxide on undifferentiated and retinoic acid-differentiated SH-SY5Y cells line10.1039/c2nr30407d ↗
53. Gold nanoparticles functionalized with angiogenin-mimicking peptides modulate cell membrane interactions10.1116/1.5022295 ↗
54. A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles10.15171/apb.2015.061 ↗
55. Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells10.1021/nn1007176 ↗
56. In vitro toxicity evaluation of graphene oxide on A549 cells10.1016/j.toxlet.2010.11.016 ↗
57. Green synthesis of graphene and its cytotoxic effects in human breast cancer cells10.2147/IJN.S42047 ↗
58. Mitochondria, oxidative stress and cell death10.1007/s10495-007-0756-2 ↗
59. Detection of gold nanoparticles with different sizes using absorption and fluorescence based method10.1016/j.snb.2015.12.044 ↗
60. Theranostic nanomedicine for cancer detection and treatment10.1016/j.jfda.2014.01.001 ↗
61. Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy10.1016/j.redox.2014.12.003 ↗
62. Kumari, S., Badana, A.K., Gavara, M.M., Gugalavath, S., and Malla, R. (2018). Reactive Oxygen Species: A Key Constituent in Cancer Survival. Biomark Insights, 13.10.1177/1177271918755391 ↗