journal article·2026-02-28Open access

Natural Bioactive Compounds as Feed Additives: Strategies for Sustainable and Functional Livestock Production

Michela Contò, Marta Castrica, Simona Rinaldi, Sebastiana Failla

Applied Sciences· Volume 16· Issue 5

Abstract

In recent years, natural bioactive compounds have been increasingly investigated as functional feed additives to enhance livestock production. The present study aims to provide an update on the potential use of these compounds to enhance animal health and the quality of animal products, while critically assessing their principal limitations and future practical applicability. The review is based on peer-reviewed articles published between 2020 and 2025 and retrieved from the Scopus database, ensuring the inclusion of recent and high-impact scientific contributions. Phytogenic feed additives, including polyphenols, terpenoids, and alkaloids, exert beneficial effects on animal health by modulating oxidative stress and inflammatory pathways. Improvements in milk and meat quality are mainly associated with enhanced antioxidant capacity and lipid stability, rather than with the direct transfer of phytochemicals into animal-derived products. In ruminants, selected bioactive compounds may also contribute to methane mitigation through modulation of rumen fermentation and microbial ecology. However, their efficacy remains highly context-dependent and requires precise characterization of composition, dosage, and species-specific application. Future research should therefore prioritize deeper elucidation of metabolic mechanisms, systemic physiological responses, and productive outcomes to better define the conditions under which these compounds exert consistent and biologically meaningful effects.
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Research context

OpenAlex topics: Ruminant Nutrition and Digestive Physiology · Plant Toxicity and Pharmacological Properties · Plant and fungal interactions

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Consiglio per la Ricerca in Agricoltura e l’Analisi dell’Economia Agraria (CREA), Centro di Ricerca Zootecnia e Acquacoltura, Via Salaria, 31, Monterotondo, 00016 Rome, Italy

Department of Comparative Biomedicine and Food Science, University of Padova, Agripolis, Viale dell’ Univesità 16, 35020 Legnaro, Italy

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