Bioactive Hydroxyapatite–Collagen Composite Dressings for Wound Regeneration: Advances in Fabrication, Functionalization and Antimicrobial Strategies
Source abstract
Abstract
Chronic and complex wounds, including diabetic foot ulcers, venous leg ulcers, burns and post-surgical defects, remain difficult to manage due to persistent inflammation, impaired angiogenesis, microbial colonization and insufficient extracellular matrix (ECM) remodeling. Conventional dressings provide protection, but they do not supply the necessary biochemical and structural signals for effective tissue repair. This review examines recent advances in hydroxyapatite–collagen (HAp–Col) composite dressings, which combine the architecture of collagen with the mechanical reinforcement and ionic bioactivity of hydroxyapatite. Analysis of the literature indicates that in situ and biomimetic mineralization, freeze-drying, electrospinning, hydrogel and film processing, and emerging 3D printing approaches enable precise control of pore structure, mineral dispersion, and degradation behavior. Antimicrobial functionalization remains critical: metallic ions and locally delivered antibiotics offer robust early antibacterial activity, while plant-derived essential oils (EOs) provide broad-spectrum antimicrobial, antioxidant and anti-inflammatory effects with reduced risk of resistance. Preclinical studies consistently report enhanced epithelialization, improved collagen deposition and reduced bacterial burden in HAp–Col systems; however, translation is limited by formulation variability, sterilization sensitivity and the lack of standardized clinical trials. Overall, HAp–Col composites represent a versatile framework for next-generation wound dressings that can address both regenerative and antimicrobial requirements.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Collagen: Extraction and Characterization · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Faculty of Dental Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 16 University Street, 700115 Iasi, Romania
Faculty of Materials Science and Engineering, National University of Science and Technology Politehnica, 060042 Bucharest, Romania
Faculty of Biotechnical Systems Engineering, National University of Science and Technology Politehnica, 060042 Bucharest, Romania
Funding
National Association of Technical Universities (ARUT), Romania
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