A Review on Bioactive Compounds and Pharmacological Activities of Citrus unshiu

Citrus constitutes a group of fruit crops that include lemons, limes, mandarins, oranges, and grapefruits. These citrus have a variety of essential nutrients and bioactive compounds that exert several pharmacological properties, including antioxidant, anti-inflammatory, anticancer, anti-diabetic, and anti-obesity. The Satsuma mandarin, also known as Citrus unshiu Marc. (C. unshiu), is one of the most popular citrus types. This is mostly due to its seedless nature, early maturity, and highly valued commercial trait in the citrus sector. The pharmacological properties and phytochemicals of the two main citrus fruits—sweet oranges (C. sinensis) and lemons (C. limon)—are given more attention. Satsuma mandarin has not, however, had its therapeutic properties thoroughly examined and explored. Therefore, the purpose of this review is to use multiple databases to compile the information currently available on the pharmacological properties and bioactive compounds of C. unshiu. The findings indicate that C. unshiu bioactives (hesperidin; hesperetin; nobiletin; narirutin; naringin; naringenin; tangeretin; 3,5,6,7,8,3′,4′-heptamethoxyflavone; neoponcirin; synephrine; quercetin; quercetagetin; rutin; β-cryptoxanthin; and pectin) exert in vitro/vivo anticancer, anti-obesity, anti-diabetic, cardioprotective, gastroprotective, neuroprotective, hepatoprotective, skin-protective, nasal airway-protective, lipid-lowering, antioxidant, anti-inflammatory, and anti-microbial activities. Future experimental investigations into the potential health benefits of C. unshiu could contribute to a better understanding of the mechanisms behind its therapeutic activities. Clinical studies are necessary to assess the therapeutic properties of C. unshiu bioactives. The therapeutic potential of C. unshiu bioactives should be determined through preclinical in vivo animal studies before they can be applied in clinical settings.