Line-Field Confocal Optical Coherence Tomography of Plaque Psoriasis Under IL-17 Inhibitor Therapy: Artificial Intelligence-Supported Analysis
Source abstract
Abstract
To date, therapeutic responses in plaque psoriasis are evaluated with clinical scores. No objective examination has been established. A recently developed non-invasive imaging tool, line-field confocal optical coherence tomography (LC-OCT), enables the in vivo live imaging of skin changes in psoriasis under therapy. The aim of this study was to measure therapeutic response clinically and with LC-OCT, comparing the subjectively scored epidermal changes with an AI-supported analysis. This prospective, observational study included 12 patients with psoriasis starting a systemic treatment with IL-17 inhibitors (secukinumab, ixekizumab, and bimekizumab). LC-OCT and clinical assessment with a local psoriasis and severity index of the study plaque and a control area were performed before the initiation of therapy as well as after 4 and 12 weeks of treatment. A manual and AI-supported measurement of the thickness of epidermis, stratum corneum, and undulation of the dermo-epidermal junction was carried out. Acanthosis and hyperkeratosis showed a significant reduction under treatment. AI-supported calculations were compared to subjective measurements showing good reliability with high correlation. AI-supported analysis of vascular changes may serve as a prognostic and therapeutic response marker in the future.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Optical Coherence Tomography Applications · Systemic Lupus Erythematosus Research · Psoriasis: Treatment and Pathogenesis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Dermatology and Allergology, University Hospital Augsburg, 86179 Augsburg, Germany
Chair for Computational Statistic and Data Analysis, Institute of Mathematics, University of Augsburg, 86156 Augsburg, Germany
References (41)
Show source-provided references
1. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics10.1016/j.jaad.2018.11.057 ↗
2. Deutsche S3-Leitlinie zur Therapie der Psoriasis vulgaris, adaptiert von EuroGuiDerm—Teil 1: Therapieziele und Therapieempfehlungen
3. Severe psoriasis--oral therapy with a new retinoid10.1159/000250839 ↗
4. The reliability of three psoriasis assessment tools: Psoriasis area and severity index, body surface area and physician global assessment10.17219/acem/69804 ↗
5. Ultra-high-frequency ultrasound monitoring of plaque psoriasis during ixekizumab treatment10.1111/srt.12942 ↗
6. Dermoscopy in Monitoring and Predicting Therapeutic Response in General Dermatology (Non-Tumoral Dermatoses): An Up-To-Date Overview10.1007/s13555-020-00455-y ↗
7. Standardization of dermoscopic terminology and basic dermoscopic parameters to evaluate in general dermatology (non-neoplastic dermatoses): An expert consensus on behalf of the International Dermoscopy Society10.1111/bjd.18125 ↗
8. Dermoscopic features of plaque psoriasis and lichen planus: New observations10.1159/000071785 ↗
9. Clinical, dermoscopic, and ultrasonic monitoring of the response to biologic treatment in patients with moderate-to-severe plaque psoriasis10.3389/fmed.2023.1162873 ↗
10. Dermoscopic features of psoriasis of the skin, scalp and nails—A systematic review10.1111/jdv.15344 ↗
11. Clinical, ultrasound, and videodermatoscopy monitoring of psoriatic patients following biological treatment10.1111/srt.12271 ↗
12. Dermoscopic hemorrhagic dots: An early predictor of response of psoriasis to biologic agents10.5826/dpc.0604a02 ↗
13. High-frequency ultrasonography of psoriatic skin: A non-invasive technique in the evaluation of the entire skin of patients with psoriasis: A pilot study
14. Evaluation of the response to treatment of psoriasis vulgaris with reflectance confocal microscopy10.1111/srt.12150 ↗
15. Optical coherence tomography of the human retina10.1001/archopht.1995.01100030081025 ↗
16. Imaging Blood Vessel Morphology in Skin: Dynamic Optical Coherence Tomography as a Novel Potential Diagnostic Tool in Dermatology10.1007/s13555-017-0175-4 ↗
17. Optical coherence tomography in contact dermatitis and psoriasis10.1007/s00403-003-0390-y ↗
18. Optical coherence tomography imaging of psoriasis vulgaris: Correlation with histology and disease severity10.1007/s00403-009-1000-4 ↗
19. Line-field confocal optical coherence tomography of psoriasis, eczema and lichen planus: A case series with histopathological correlation10.1111/jdv.18293 ↗
20. Kempf, W., Hantschke, M., Kutzner, H., and Burgdorf, W. (2015). Dermatopathologie, Springer. [3rd ed.].10.1007/978-3-662-46408-3 ↗
21. Line-field confocal optical coherence tomography imaging findings of scalp psoriasis10.1016/j.jdcr.2023.06.050 ↗
22. Line-field confocal optical coherence tomography: New insights for psoriasis treatment monitoring10.1111/jdv.19568 ↗
23. Confocal line-field OCT10.1007/s00105-021-04900-7 ↗
24. Line-field confocal optical coherence tomography-Practical applications in dermatology and comparison with established imaging methods10.1111/srt.12949 ↗
25. Latriglia, F., Ogien, J., Tavernier, C., Fischman, S., Suppa, M., Perrot, J.L., and Dubois, A. (2023). Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Skin Imaging in Dermatology. Life, 13.10.3390/life13122268 ↗
26. Comparison of Guidelines for the Use of Interleukin-17 Inhibitors for Psoriasis in the United States, Britain, and Europe: A Critical Appraisal and Comprehensive Review
27. Plaque-Type Psoriasis Treated with Calcipotriene Plus Betamethasone Dipropionate Aerosol Foam: A Prospective Study on Clinical and Dermoscopic Predictor Factors in Response Achievement and Retention10.1007/s13555-020-00406-7 ↗
28. Comparison of facial skin ageing in healthy Asian and Caucasian females quantified by in vivo line-field confocal optical coherence tomography 3D imaging10.1111/srt.13643 ↗
29. Assi, A., Fischman, S., Lopez, C., Pedrazzani, M., Grignon, G., Missodey, R., Korichi, R., Cauchard, J.H., Ralambondrainy, S., and Bonnier, F. (2024). Evaluating facial dermis aging in healthy Caucasian females with LC-OCT and deep learning. Sci. Rep., 14.10.1038/s41598-024-74370-z ↗
30. Bonnier, F., Pedrazzani, M., Fischman, S., Viel, T., Lavoix, A., Pegoud, D., Nili, M., Jimenez, Y., Ralambondrainy, S., and Cauchard, J.H. (2023). Line-field confocal optical coherence tomography coupled with artificial intelligence algorithms to identify quantitative biomarkers of facial skin ageing. Sci. Rep., 13.10.1038/s41598-023-40340-0 ↗
31. Utilizing deep learning for dermal matrix quality assessment on in vivo line-field confocal optical coherence tomography images10.1111/srt.13221 ↗
32. Daxenberger, F., Deußing, M., Eijkenboom, Q., Gust, C., Thamm, J., Hartmann, D., French, L.E., Welzel, J., Schuh, S., and Sattler, E.C. (2023). Innovation in Actinic Keratosis Assessment: Artificial Intelligence-Based Approach to LC-OCT PRO Score Evaluation. Cancers, 15.10.3390/cancers15184457 ↗
33. Fischman, S., Pérez-Anker, J., Tognetti, L., Di Naro, A., Suppa, M., Cinotti, E., Viel, T., Monnier, J., Rubegni, P., and Del Marmol, V. (2022). Non-invasive scoring of cellular atypia in keratinocyte cancers in 3D LC-OCT images using Deep Learning. Sci. Rep., 12.10.1038/s41598-021-04395-1 ↗
34. Epidermal renewal during the treatment of atopic dermatitis lesions: A study coupling line-field confocal optical coherence tomography with artificial intelligence quantifications: LC-OCT reveals new biological markers of AD10.1111/srt.13891 ↗
35. Artificial intelligence-based PRO score assessment in actinic keratoses from LC-OCT imaging using Convolutional Neural Networks
36. Chauvel-Picard, J., Bérot, V., Tognetti, L., Orte Cano, C., Fontaine, M., Lenoir, C., Pérez-Anker, J., Puig, S., Dubois, A., and Forestier, S. (2022). Line-field confocal optical coherence tomography as a tool for three-dimensional in vivo quantification of healthy epidermis: A pilot study. J. Biophotonics, 15.10.1002/jbio.202100236 ↗
37. Illuminating characteristic patterns of inflammatory dermatoses: A comprehensive dual-imaging approach using Optical coherence tomography and Line-field confocal optical coherence tomography10.1111/srt.13833 ↗
38. Active and inactive edges of psoriatic plaques: Identification by tracing and investigation by laser--Doppler flowmetry and immunocytochemical techniques10.1111/1523-1747.ep12696791 ↗
39. Investigations of the ’active’ edge of plaque psoriasis: Vascular proliferation precedes changes in epidermal keratin10.1111/j.1365-2133.1994.tb08582.x ↗
40. Cutaneous vascular alterations in psoriatic patients treated with cyclosporine10.2340/00015555-0216 ↗
41. Measurement of epidermal thickness in a patient with psoriasis by computer-supported image analysis10.1590/S0100-879X2004000100015 ↗