Theoretical and Experimental Analysis of the Effect of Vaporization Heat on the Interaction between Laser and Biological Tissue
Source abstract
Abstract
A theoretical model, based on the classical Pennes’ bioheat theory, incorporating various boundary conditions, was established and compared to analyze the influence of the latent heat of vaporization via simulation. The aim was to elucidate the extent of its influence. The thermal damage rate, governed by the vaporization heat of biological tissue, is introduced as a key factor. Functional relationships between temperature and incident laser power, spatial position, and time are derived from the classical Pennes’ bioheat equation. According to the theoretical model, numerical simulations and experimental validations are conducted using Comsol Multiphysics 6.0, considering the tissue latent heat of vaporization. The model incorporating the latent heat of vaporization proved more suitable for analyzing the interactions between laser and biological tissue, evident from the degree of fit between simulated and experimental data. The minimum deviations between theoretical and experimental observations were determined to be 2.43% and 5.11% in temperature and thermal damage, respectively. Furthermore, this model can be extended to facilitate the theoretical analysis of the impact of vaporization heat from different primary tissue components on laser-tissue interaction.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Thermography and Photoacoustic Techniques · Thermoelastic and Magnetoelastic Phenomena · Photoacoustic and Ultrasonic Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Science, Yanshan University, Qinhuangdao 066004, China
Key Lab of Solid-State Laser, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Key Lab of Functional Crystal and Laser Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
University of Chinese Academy of Sciences, Beijing 100190, China
Institute of Optical Physics and Engineering Technology, Qilu Zhongke, Jinan 250000, China
Funding
Global Common Challenges Project of International Partnership Program of Chinese Academy of Sciences · National Key Research and Development Program of China · National Special Support Program for high-level Talents Science and Technology · Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences · Key Laboratory Foundation of Chinese Academy of Sciences · Key Lab of Solid State Laser · Talent introduction training program of Institute of Optical Physics and Engineering Technology
References (35)
Show source-provided references
1. Numerical analysis of the interactions between laser and soft tissues using generalized dual-phase lag equation10.1016/j.apm.2015.10.025 ↗
2. Analysis of the dual phase lag bio-heat transfer equation with constant and time-dependent heat flux constant on skin surface10.2298/TSCI140128057Z ↗
3. Modified Pennes bioheat equation with heterogeneous blood perfusion: A newer perspective10.1016/j.ijheatmasstransfer.2023.124698 ↗
4. Measurement and Analysis of Tissue Temperature During Microwave Liver Ablation10.1109/TBME.2006.884647 ↗
5. Expanding the Bioheat Equation to Include Tissue Internal Water Evaporation During Heating10.1109/TBME.2007.890740 ↗
6. Numerical models to evaluate the temperature increase induced by ex vivo microwave thermal ablation10.1088/0031-9155/60/8/3287 ↗
7. Thermomechanical Modeling of Laser Ablation Therapy of Tumors Sensitivity Analysis and Optimization of Influential Variables10.1109/TBME.2021.3092889 ↗
8. Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor10.1038/s41598-023-37859-7 ↗
9. Mohammazadeh, A., Mahmouie, S., and Far, A.M. (2020, January 4–6). Monte Carlo and Bioheat Transfer Simulation of Dual Sequential Wavelength Laser for Port Wine Stains Treatment. Proceedings of the 2020 28th Iranian Conference on Electrical Engineering (ICEE), Tabriz, Iran.10.1109/ICEE50131.2020.9260635 ↗
10. Analysis of the time-space fractional bioheat transfer equation for biological tissues during laser irradiation10.1016/j.ijheatmasstransfer.2021.121555 ↗
11. Conjugate heat transfer analysis of laser-irradiated cylindrical-shaped biological tissue embedded with the optical inhomogeneity10.1016/j.icheatmasstransfer.2022.106302 ↗
12. Partovi, B., Ahmadikia, H., and Mosharaf-Dehkordi, M. (2023). Analytical and numerical analysis of the dual-pulse lag heat transfer in a three-dimensional tissue subjected to a moving multi-point laser beam. J. Therm. Biol., 112.10.1016/j.jtherbio.2022.103431 ↗
13. Thermoelastic analysis of biological tissue during hyperthermia treatment for moving laser heating using fractional dual-phase-lag bioheat conduction10.1016/j.ijthermalsci.2022.107806 ↗
14. Thermal damage in three-dimensional vivo bio-tissues induced by moving heat sources in laser therapy10.1038/s41598-019-47435-7 ↗
15. Quasi-distributed fiber optic sensor-based control system for interstitial laser ablation of tissue: Theoretical and experimental investigations10.1364/BOE.419541 ↗
16. Pham, N.T., Lee, S.L., Park, S., Lee, Y.W., and Kang, H.W. (2017). Real-time temperature monitoring with fiber Bragg grating sensor during diffuser-assisted laser-induced interstitial thermotherapy. J. Biomed. Opt., 22.10.1117/1.JBO.22.4.045008 ↗
17. Quantitative evaluation of effects of coupled temperature elevation, thermal damage, and enlarged porosity on nanoparticle migration in tumors during magnetic nanoparticle hyperthermia10.1016/j.icheatmasstransfer.2021.105393 ↗
18. Towards personalized and versatile monitoring of temperature fields within heterogeneous tissues during laser therapies10.1364/BOE.428028 ↗
19. Singh, M., Singh, T., and Soni, S. (2021). Pre-operative Assessment of Ablation Margins for Variable Blood Perfusion Metrics in a Magnetic Resonance Imaging Based Complex Breast Tumour Anatomy: Simulation Paradigms in Thermal Therapies. Comput. Methods Programs Biomed., 198.10.1016/j.cmpb.2020.105781 ↗
20. Analysis of tissue and arterial blood temperatures in the resting human forearm10.1152/jappl.1948.1.2.93 ↗
21. A numerical simulation of photothermal response in laser medicine
22. Studies of Thermal Injury: II. The Relative Importance of Time and Surface Temperature in the Causation of Cutaneous Burns
23. Studies of Thermal Injury: I. The Conduction of Heat to and through Skin and the Temperatures Attained Therein. A Theoretical and an Experimental Investigation
24. Studies of thermal injury; the predictability and the significance of thermally induced rate processes leading to irreversible epidermal injury
25. Diffusion of light in turbid material10.1364/AO.28.002210 ↗
26. Photothermal and photoacoustic properties of biological tissues with micro tumors under the action of pulsed laser10.1016/j.ijleo.2022.169637 ↗
27. Ye, Y. (2020). Experimental Research and Device Design of Laser-Induced Thermal Damage to Biological Tissues. [Master’s Thesis, South China University of Technology].
28. Temperature Simulation Model of Tumor Tissue in Tumor Bearing Mice during Photothermal Therapy
29. Zhang, S., Li, C., Cao, L., Moser, M.A.J., Zhang, W., Qian, Z., and Zhang, B. (2022). Modeling and ex vivo experimental validation of liver tissue carbonization with laser ablation. Comput. Methods Programs Biomed., 217.10.1016/j.cmpb.2022.106697 ↗
30. Rui, S., Mi, Y., Liu, L., Yao, C., and Li, C. (June, January 31). Study on temperature of liver and tumor under high frequency nanosecond pulsed field. Proceedings of the 2015 IEEE Pulsed Power Conference (PPC), Austin, TX, USA.10.1109/PPC.2015.7296955 ↗
31. Multi-parametric study of temperature and thermal damage of tumor exposed to high-frequency nanosecond-pulsed electric fields based on finite element simulation Med10.1007/s11517-016-1589-3 ↗
32. Incorporating vascular-stasis based blood perfusion to evaluate the thermal signatures of cell-death using modified Arrhenius equation with regeneration of living tissues during nanoparticle-assisted thermal therapy10.1016/j.icheatmasstransfer.2022.106046 ↗
33. Heating Protocol Design Affected by Nanoparticle Redistribution and Thermal Damage Model in Magnetic Nanoparticle Hyperthermia for Cancer Treatment10.1115/1.4046967 ↗
34. An effective rule for translating optimal selective laser melting processing parameters from one material to another
35. A simple methodology for predicting laser-weld properties from material and laser parameters10.1088/0022-3727/44/44/445401 ↗