Silent Disruptors: The Multifaceted Impact of Phthalates Across Aquatic Invertebrate and Vertebrate Taxa
Source abstract
Abstract
Phthalic acid esters (PAEs) are ubiquitous pollutants with reported endocrine-disruption and multiplex toxic activities in a wide range of invertebrate and vertebrate animals. In the present review, the molecular and physiological effects of phthalate exposure on invertebrates, as well as less characterized vertebrates such as amphibians, reptiles, and mammals, are thoroughly examined. PAEs induce a series of adverse effects, such as reproductive toxicity, oxidative stress, immune system impairment, and neuroendocrine disruption. The effects can extensively vary depending on the species, developmental stage, and environmental conditions, ranging from impaired hormone signaling, developmental malformations, and thyroid impairment in amphibians and reptiles to lipid metabolism disturbances and epigenetic changes in mammals. This review will place particular emphasis on transgenerational effects, mixture toxicity, and chronic low-level exposure. By integrating evidence from in vivo, in vitro, and omics studies, this review defines areas of knowledge gaps and the necessity to integrate these taxa in integrated ecological risk assessments, as well as regulatory policy.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Effects and risks of endocrine disrupting chemicals · Environmental Toxicology and Ecotoxicology · Immunotoxicology and immune responses
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90100 Palermo, Italy
National Biodiversity Future Center (NBFC), 90133 Palermo, Italy
Physical and Chemical Department, University of Palermo, 90100 Palermo, Italy
Funding
European Union—NextGenerationEU · Italian Ministry of University and Research
References (100+)
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