journal article·2025-07-30Open access

Potential Metal Contamination in Foods of Animal Origin—Food Safety Aspects

József Lehel, Dániel Pleva, Attila László Nagy, Miklós Süth, Tibor Kocsner

Applied Sciences· Volume 15· Issue 15

Abstract

This literature review provides an overview of the food safety and toxicological characteristics of various heavy metals and metalloids and the public health significance of their occurrence in food. Metals also occur as natural components of the environment, but they can enter food of animal origin and the human body primarily due to anthropogenic (industrial, agricultural, transport-related) activities. The persistent heavy metals (e.g., Hg, Pb, Cd) found in the environment are not biodegradable, can accumulate, and can enter the bodies of higher animals and subsequently, humans, where they are metabolized into various compounds with differing toxicity. Thus, due to their environmental contamination, they can accumulate in living organisms and their presence in the food chain is of great concern for human health. Regulations of the European Community in force lay down maximum levels for a limited number of metals, and the types of regulated foodstuffs of animal origin are also narrower than in the past, e.g., wild game animals and eggs are not included. The regulation of game meat (including offal) deserves consideration, given that it is in close interaction with the environmental condition of a given area and serves as indicator of it.
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Research context

OpenAlex topics: Heavy metals in environment · Heavy Metal Exposure and Toxicity · Mercury impact and mitigation studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Food Hygiene, Institute of Food Chain Science, University of Veterinary Medicine Budapest, István u. 2., 1078 Budapest, Hungary

Institute of Food Chain Science, University of Veterinary Medicine Budapest, István u. 2., 1078 Budapest, Hungary

References (100+)

Show source-provided references
1. Campbell, P.G.C., Stokes, P.M., and Galloway, J.N. (1983). The effect of atmospheric deposition on the geochemical cycling and biological avaibality of metals. Heavy Metals in the Environment, Proceedings of the Heidelberg International Conference, Heidelberg, Germany, 20–27 September 1967, CEC Consultants.
2. Láng, I. (2002). Környezet és Természetvédelmi Lexikon I-II, Akadémiai Kiadó. (In Hungarian).
3. Papp, S., and Kümmel, R. (1992). Környezeti Kémia, Akadémiai Kiadó. (In Hungarian).
4. Arsenic
5. Lehel, J., and Laczay, P. (2010). Toxikológia, Szent István Egyetemi Nyomda. (In Hungarian).
6. Ultratrace elements in nutrition: Current knowledge and speculation10.1002/(SICI)1520-670X(1998)11:2/3<251::AID-JTRA15>3.0.CO;2-Q ↗
7. Chappell, W.R., Abernathy, C.O., and Cothern, C.R. (1994). Arsenic essentiality and factors affecting its importance. Arsenic. Exposure and Health, Science and Technology Letters.
8. Toxicity, mechanism and health effects of some heavy metals10.2478/intox-2014-0009 ↗
9. Gahlowt, P., Singh, S., Gupta, R., Zheng, B.S., Tripathi, D.K., and Singh, V.P. (2025). Arsenite in plant biology: How plants tackle it?. Plant Physiol. Biochem., 219.10.1016/j.plaphy.2024.109332 ↗
10. Abbas, G., Murtaza, B., Bibi, I., Shahid, M., Niazi, N.K., Khan, M.I., Amjad, M., Hussain, M. (2018). Arsenic Uptake, Toxicity, De-toxification, and Speciation in Plants: Physiological, Biochemical, and Molecular Aspects. Int. J. Environ. Res. Public Health, 15.10.3390/ijerph15010059 ↗
11. Arsenic. Elements and Their Compounds in the Environment: Occurrence, Analysis and Biological Relevance
12. Arsenic toxicity and potential mechanisms of action10.1016/S0378-4274(02)00084-X ↗
13. Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites10.1006/taap.2001.9157 ↗
14. The cellular metabolism and systemic toxicity of arsenic10.1006/taap.2001.9258 ↗
15. A review of animal models for the study of arsenic carcinogenesis10.1016/S0378-4274(02)00086-3 ↗
16. Lederer, W.H., and Fensterheim, R.J. (1983). Toxicology of prenatal exposure to arsenic. Arsenic: Industrial, Biomedical, Environmental Perspectives, Van Nostrand Reinhold.
17. Human studies do not support the methylation threshold hypothesis for the toxicity of inorganic arsenic10.1006/enrs.1993.1024 ↗
18. Chappell, W.R., Abernathy, C.O., and Calderon, R.L. (2001). The discovery, importance and significance of monomethylarsonous acid (MMAIII) in urine of humans exposed to inorganic arsenic. Arsenic Exposure and Health Effects IV, Elsevier Science.
19. Arsenic metabolites in human urine after ingestion of an arsenosugar10.1093/clinchem/48.1.92 ↗
20. Factors influencing arsenic methylation in humans10.1002/(SICI)1520-670X(2000)13:1<173::AID-JTRA18>3.0.CO;2-T ↗
21. Concentrations and chemical species of arsenic in human urine and hair10.1007/BF01697507 ↗
22. Toxicity and physiological disposition of sodium p-N-glycolylarsanilate. I. Observations in mouse, cat, rat, and man10.1016/0041-008X(62)90071-6 ↗
23. Arsenic: Health effects, mechanisms of actions, and research issues10.1289/ehp.99107593 ↗
24. Total and inorganic arsenic in fish, seafood and seaweeds-exposure assessment
25. Heavy metals in marine fish meat and consumer health: A review10.1002/jsfa.7360 ↗
26. Heavy metals in seafood purchased from a fishery market in Hungary10.1080/19393210.2018.1505781 ↗
27. Toxic elements in Sardina pilchardus and food toxicological significance10.1080/19393210.2022.2081733 ↗
28. Lehel, J., Papp, Z., Bartha, A., Palotás, P., Szabó, R., Budai, P., and Süth, M. (2023). Metal Load of Potentially Toxic Elements in Tuna (Thunnus albacares)—Food Safety Aspects. Foods, 12.10.3390/foods12163038 ↗
29. Lehel, J., Plachy, M., Palotás, P., Bartha, A., and Budai, P. (2024). Possible Metal Burden of Potentially Toxic Elements in Rainbow Trout (Oncorhynchus mykiss) on Aquaculture Farm. Fishes, 9.10.3390/fishes9070252 ↗
30. Excretion of a single oral dose of fish-arsenic in man10.1007/BF01605634 ↗
31. Roussel, A.M., Anderson, R.A., and Favier, A.E. (2000). Metabolism of arsenic from seaweed by man and animals. Trace Elements in Man and Animals 10, Kluwer Academic/Plenum Publishers.
32. Toxic heavy metals in the muscle of roe deer (Capreolus capreolus) food toxicological significance10.1007/s11356-015-5658-1 ↗
33. EFSA (European Food Safety Authority) (2009). Scientific opinion on arsenic in food. EFSA J., 7, 1351.10.2903/j.efsa.2009.1351 ↗
34. Cadmium as an environmental hazard
35. ATSDR (Agency for Toxic Substances and Disease Registry) (2025, January 25). Toxicological Profile for Cadmium, Available online: https://www.atsdr.cdc.gov/toxprofiles/tp5.pdf.
36. Cadmium in the environment: Sources, mechanisms of biotoxicity, and biomarkers10.1515/REVEH.2000.15.3.299 ↗
37. Butterman, W.C., and Plachy, J. (2024, December 12). Cadmium, U.S. Geological Survey Minerals Yearbook: Cadmium, Available online: https://pubs.usgs.gov/of/2002/of02-238/of02-238.pdf.
38. Crop uptake of cadmium from phosphorus fertilizers10.1007/BF00479793 ↗
39. Cadmium from soil amended with sewage sludge: Effects and residues in swine10.1289/ehp.792851 ↗
40. Effect of cadmium on lipid peroxidation and antioxidant enzymes in undernourished weanling rat brain10.1111/j.1600-0773.1989.tb01130.x ↗
41. Mediation of cadmium-induced oxidative damage and glucose-6-phosphate dehydrogenase expression through glutathione depletion10.1002/jbt.10062 ↗
42. IARC (International Agency for Research on Cancer) (2025, February 02). Agents Classified by the IARC Monographs, Volumes 1–138. Available online: https://monographs.iarc.who.int/agents-classified-by-the-iarc/.
43. Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland10.1038/nm902 ↗
44. Comparison of renal toxicity after long-term oral administration of cadmium chloride and cadmium-metallothionein in rats10.1006/faat.1994.1139 ↗
45. Comparison of the toxicity of inorganic and liver-incorporated cadmium: A 4-wk feeding study in rats10.1016/0278-6915(90)90090-A ↗
46. Molecular handling of cadmium in transporting epithelia10.1016/S0041-008X(02)00021-2 ↗
47. Discrepancy between the nephrotoxic potencies of cadmium-metallothionein and cadmium chloride and the renal concentration of cadmium in the proximal convoluted tubules10.1006/taap.1995.1021 ↗
48. Cadmium absorption in mice: Effects of broiling on bioavailability of cadmium in foods of animal origin10.1080/009841001459423 ↗
49. Bioavailability of cadmium from crab hepatopancreas and mushroom in relation to inorganic cadmium: A 9-week feeding study in mice10.1016/0278-6915(95)00036-2 ↗
50. Effects of dietary cadmium chloride throughout gestation on blood and tissue metabolites of primigravid and neonatal dairy cattle10.2527/1991.69104078x ↗
51. Heavy metal retention in cattle tissues from infestation of sewage sludge10.2134/jeq1982.00472425001100040012x ↗
52. Cadmium uptake from feed and its distribution to food products of livestock10.1289/ehp.792859 ↗
53. The effect of dietary cadmium intake on the growth performance and retention of cadmium in growing pigs10.1016/0377-8401(92)90115-M ↗
54. Cadmium accumulation and protein binding patterns in tissues of the rainbow trout, Salmo gairdneri
55. Murphy, E.W., Brewington, C.R., Welss, B.W., and Nelson, M.A. (1979). Health and Safety Aspects of the Use of Mechanically Deboned Poultry, Food Safety and Quality Services, Department of Agriculture.
56. Cadmium and the food chain: The effect of dietary cadmium on tissue composition in chicks and laying hens10.1093/jn/109.3.437 ↗
57. Restriction of cadmium transfer to eggs from laying hens exposed to cadmium10.1080/00984109708984008 ↗
58. Accumulation and depletion of cadmium and lead in tissues and milk of lactating cows fed small amounts of these metals10.3168/jds.S0022-0302(82)82298-4 ↗
59. Effects of long-term dietary cadmium chloride on tissue, milk, and urine mineral concentrations of lactating dairy cows10.2527/1991.69104088x ↗
60. Transfer and distribution of radioactive cadmium in dairy cows10.1080/00207238208709964 ↗
61. Soil and agronomic factors associated with cadmium accumulations in kidneys of grazing sheep10.1111/j.1751-0813.1994.tb00953.x ↗
62. Food safety aspects of primary environmental contaminants in the edible tissues of roe deer (Capreolus capreolus)10.1007/s11356-017-0206-9 ↗
63. EFSA (European Food Safety Authority) (2009). Cadmium in food—Scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J., 980, 1–139.10.2903/j.efsa.2009.980 ↗
64. ATSDR (Agency for Toxic Substances and Disease Registry) (2025, January 25). Toxicological Profile for Lead, Available online: https://www.atsdr.cdc.gov/toxprofiles/tp13.pdf.
65. IPCS (International Programme on Chemical Safety) (1989). Environmental Health Criteria 85: Lead, Environmental Aspects, World Health Organization. Available online: https://iris.who.int/bitstream/handle/10665/40020/9241542853-eng.pdf?sequence=1.
66. Lead levels in blood from cattle residing near a lead smelter10.2134/jeq1992.00472425002100020005x ↗
67. Migration of lead in a glass-lined bottom-unloading silo
68. Mechanism of lead neurotoxicity10.1016/0006-2952(91)90617-E ↗
69. Lead-protein interactions as a basis for lead toxicity
70. Evidence that lead acts as a calcium substitute in second messenger metabolism
71. Antioxidant nutrients and lead toxicity10.1016/S0300-483X(02)00380-3 ↗
72. Lead toxicity and heme biosynthesis
73. Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase10.1016/S0968-0004(98)01219-5 ↗
74. Cardiovascular actions of lead and relationship to hypertension: A review10.1289/ehp.887891 ↗
75. Pathogenesis of lead-induced hypertension: Role of oxidative stress
76. Ca2+/calmodulin-mediated neurotransmitter release and neurobehavioural deficits following lead exposure10.1002/cbf.1030 ↗
77. Molecular mechanisms of lead neurotoxicity10.1023/A:1022596115897 ↗
78. Selective vulnerability of the developing brain to lead10.1097/00019052-199812000-00013 ↗
79. Molecular targets of lead in brain neurotoxicity10.1007/BF03033142 ↗
80. Intestinal calcium and lead absorption: Effects of dietary lead and calcium10.1016/S0013-9351(05)80098-2 ↗
81. Calcium supplementation efficiently reduces lead absorption in suckling rats10.1034/j.1600-0773.2001.d01-169.x ↗
82. Partition of circulating lead between serum and red cells is different for internal and external sources of lead10.1002/(SICI)1097-0274(199605)29:5<440::AID-AJIM2>3.0.CO;2-Q ↗
83. Roles of lead-binding proteins in mediating lead bioavailability10.1289/ehp.98106s61585 ↗
84. A physiologically based kinetic model for lead in children and adults10.1289/ehp.98106s61495 ↗
85. Lead in bone: Storage site, exposure source, and target organ
86. IPCS (International Programme on Chemical Safety) (1995). Environmental Health Criteria 165: Inorganic Lead, World Health Organization. Available online: https://iris.who.int/bitstream/handle/10665/37241/9241571659-eng.pdf.
87. Transplacental transport of lead10.1289/ehp.9089101 ↗
88. Transplancental kinetics of lead in pregnant mini-pigs10.1007/s002040050374 ↗
89. Biliary excretion of lead in rats, rabbits, and dogs10.1016/0041-008X(74)90115-X ↗
90. The effect of chronic lead intoxication in mature chickens10.2307/1591121 ↗
91. The distribution of lead in milk and the fate of milk lead in the gastrointestinal tract of suckling rats10.1203/00006450-198801000-00013 ↗
92. Selenium and 17 other largely essential and toxic metals in muscle and organ meats of Red Deer (Cervus elaphus)—Consequences to human health10.1016/j.envint.2011.02.017 ↗
93. Risks to human health from ammunition-derived lead in Europe10.1007/s13280-019-01194-x ↗
94. Green, P. (2015). The risks to human health through livestock feeding in areas of lead shot deposition. Lead Ammunition, Wildlife and Human Health, Lead Ammunition Group, Department for Environment, Food and Rural Affairs and the Food Standards Agency. Available online: http://www.leadammunitiongroup.org.uk/wp-content/uploads/2015/06/LAG-Report-June-2015-Appendices-without-Appendix-6.pdf.
95. Elevated blood lead levels associated with retained bullet fragments—United States, 2003–201210.15585/mmwr.mm6605a2 ↗
96. Egri, B. (2017). Mérgezések. Az Állategészségvédelem Alapjai, Mezőgazda Lap- és Könyvkiadó. (In Hungarian).
97. Sex- and age-dependent accumulation of heavy metals (Cd, Pb and Zn) in liver, kidney and muscle of roe deer (Capreolus capreolus) from NW Spain10.1080/10934529.2011.532422 ↗
98. Wild boar tissue levels of cadmium, lead and mercury in seven regions of continental Croatia10.1007/s00128-010-9999-7 ↗
99. Chemical composition of wild boar meat and relationship between age and bioaccumulation of heavy metals in muscle and liver tissue10.1080/19440040903493785 ↗
100. Cadmium, lead, and chromium in large game: A local-scale exposure assessment for hunters consuming meat and liver of wild boar10.1007/s00244-012-9791-2 ↗