Machine Learning for Predicting Neutron Effective Dose
Source abstract
Abstract
The calculation of effective doses is crucial in many medical and radiation fields in order to ensure safety and compliance with regulatory limits. Traditionally, Monte Carlo codes using detailed human body computational phantoms have been used for such calculations. Monte Carlo dose calculations can be time-consuming and require expertise in different processes when building the computational phantom and dose calculations. This study employs various machine learning (ML) algorithms to predict the organ doses and effective dose conversion coefficients (DCCs) from different anthropomorphic phantoms. A comprehensive data set comprising neutron energy bins, organ labels, masses, and densities is compiled from Monte Carlo studies, and it is used to train and evaluate the supervised ML models. This study includes a broad range of phantoms, including those from the International Commission on Radiation Protection (ICRP-110, ICRP-116 phantom), the Visible-Human Project (VIP-man phantom), and the Medical Internal Radiation Dose Committee (MIRD-Phantom), with row data prepared using numerical data and organ categorical labeled data. Extreme gradient boosting (XGB), gradient boosting (GB), and the random forest-based Extra Trees regressor are employed to assess the performance of the ML models against published ICRP neutron DCC values using the mean square error, mean absolute error, and R2 metrics. The results demonstrate that the ML predictions significantly vary in lower energy ranges and vary less in higher neutron energy ranges while showing good agreement with ICRP values at mid-range energies. Moreover, the categorical data models align closely with the reference doses, suggesting the potential of ML in predicting effective doses for custom phantoms based on regional populations, such as the Saudi voxel-based model. This study paves the way for efficient dose prediction using ML, particularly in scenarios requiring rapid results without extensive computational resources or expertise. The findings also indicate potential improvements in data representation and the inclusion of larger data sets to refine model accuracy and prevent overfitting. Thus, ML methods can serve as valuable techniques for the continued development of personalized dosimetry.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Radiation Therapy and Dosimetry · Advanced Radiotherapy Techniques · Radiation Dose and Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Radiological Sciences, College of Applied Medical Science, Imam Abdulrahman Bin Faisal University, P.O. Box 2435, Dammam 31441, Saudi Arabia
References (24)
Show source-provided references
1. Snyder, W.S., Ford, M.R., Warner, G.G., and Fisher, H.L. (1969). Estimates of Absorbed Fractions for Monoenergetic Photon Sources Uniformly Distributed in Various Organs of a Heterogeneous Phantom, Oak Ridge National Lab.
2. The MIRD perspective 1999
3. Virtual clinical trials in medical imaging: A review10.1117/1.JMI.7.4.042805 ↗
4. ICRP publication 145: Adult mesh-type reference computational phantoms10.1177/0146645319893605 ↗
5. A review of computational phantoms for quality assurance in radiology and radiotherapy in the deep-learning era10.14407/jrpr.2021.00402 ↗
6. International Commission on Radiological Protection (1977). Recommendations of the International Commission on Radiological Protection, ICRP Publication. ICRP Publication 26.
7. International Commission on Radiological Protection (1991). 1990 Recommendations of the International Commission on Radiological Protection, The International Commission on Radiological Protection. ICRP Publication 60.
8. Calculation of effective dose10.1118/1.598948 ↗
9. Scott, J.A. (1992). Photon, Electron, Proton and Neutron Interaction Data for Body Tissues: ICRU Report 46, International Commission on Radiation Units and Measurements.
10. Zankl, M., Schlattl, H., Petoussi-Henss, N., and Hoeschen, C. (2012). Electron specific absorbed fractions for the adult male and female ICRP/ICRU reference computational phantoms. Phys. Med. Biol., 57.10.1088/0031-9155/57/14/4501 ↗
11. Wang, M., Zhang, Q., Lam, S., Cai, J., and Yang, R. (2020). A review on application of deep learning algorithms in external beam radiotherapy automated treatment planning. Front. Oncol., 10.10.3389/fonc.2020.580919 ↗
12. Shao, W., Lin, X., Yi, Y., Huang, Y., Qu, L., Zhuo, W., and Liu, H. (2024). Fast prediction of patient-specific organ doses in brain CT scans using support vector regression algorithm. Phys. Med. Biol., 69.10.1088/1361-6560/ad14c7 ↗
13. ICRPP (2009). Adult reference computational phantoms. ICRP Publication 110. Ann. ICRP., 39, 1.
14. ICRP (2010). Conversion Coefficients for Radiological Protection Quantities for External Radiation Exposures. ICRP Publication 116. Ann. ICRP, 40, 2–5.10.1016/j.icrp.2011.10.001 ↗
15. Bozkurt, A., Chao, T.C., and Xu, X.G. (2000). Fluence-to-dose conversion coefficients from monoenergetic neutrons below 20 MeV based on the VIP-man anatomical model. Phys. Med. Biol., 45.10.1088/0031-9155/45/10/321 ↗
16. Assessment of neutron fluence to organ dose conversion coefficients in the ORNL analytical adult phantom10.1088/0952-4746/29/1/003 ↗
17. Fluence-to-effective dose conversion coefficients from a Saudi population based phantom for monoenergetic photon beams from 10 keV to 20 MeV10.1088/0952-4746/35/1/75 ↗
18. Raschka, S., and Mirjalili, V. (2019). Python Machine Learning: Machine Learning and Deep Learning with Python, Scikit-Learn, and TensorFlow 2, Packt Publishing Ltd.
19. Deka, B., Maji, P., Mitra, S., Bhattacharyya, D., Bora, P., and Pal, S. (2019, January 17–20). Pattern Recognition and Machine Intelligence. Proceedings of the 8th International Conference, PReMI 2019, Tezpur, India.10.1007/978-3-030-34869-4 ↗
20. Extremely randomized trees10.1007/s10994-006-6226-1 ↗
21. Machine learning for radiation outcome modeling and prediction10.1002/mp.13570 ↗
22. Scikit-learn: Machine learning in Python
23. Cordeiro, T.P.V., Silva, A.X., and Crispim, V.R. (October, January 27). Calculation of conversion coefficients for effective dose for neutrons using a female voxel anthropomorphic model and the MCNPX code. Proceedings of the INAC 2009: International Nuclear Atlantic Conference. Innovations in Nuclear Technology for a Sustainable Future, Rio de Janeiro, Brazil.
24. Neutron-fluence-to-dose conversion coefficients in an anthropomorphic phantom10.1093/rpd/nci268 ↗