DRDA-Net: Deep Residual Dual-Attention Network with Multi-Scale Approach for Enhancing Liver and Tumor Segmentation from CT Images

Liver cancer is a major global health challenge, significantly contributing to mortality rates. The accurate segmentation of liver and tumors from clinical CT images plays a crucial role in selecting therapeutic strategies for liver disease and treatment monitoring but remains challenging due to liver shape variability, proximity to other organs, low contrast between tumors and healthy tissues, and unclear lesion boundaries. To address these challenges, we propose the Deep Residual Dual-Attention Network (DRDA-Net), a novel model for end-to-end liver and tumor segmentation. DRDA-Net integrates a Residual UNet architecture with dual-attention mechanisms, multi-scale tile and patch extraction, and an Ensemble method. The dual-attention mechanisms enhance focus on key regions, addressing variations in size, shape, and intensity, while the multi-scale approach captures fine details and broader contexts. Additionally, we introduce a unique pre-processing pipeline employing a two-channel denoising technique using convolutional neural networks (CNNs) and stationary wavelet transforms (SWTs) to reduce noise while preserving structural details. Evaluated on the 3DIRCADb dataset, DRDA-Net achieved Dice scores of 97.03% and 75.4% for liver and tumor segmentation, respectively, outperforming state-of-the-art methods. These results demonstrate the model’s effectiveness in overcoming segmentation challenges and highlight its potential to improve liver cancer diagnostics and treatment planning.